Epidemiological Features of Hepatitis C Virus Infection in the Russian Federation in 1994–2013

Trifonova, Galina; Левакова, И. А.; Bolsun, D D; Мукомолов, С. Л.

doi:10.15789/2220-7619-2014-3-267-274

Cited by 8 publications

(3 citation statements)

References 4 publications

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“…Ежегодно в мире инфицируются вирусом гепатита С 3-4 млн человек [1][2][3][4]. В Российской Федерации (РФ), как и во многих странах, наблюдается неблагоприятная эпидемическая ситуация по парентеральным вирусным гепатитам [5,6]. Высокая распространенность ВГС определяется преимущественно бессимптомным или субклиническим течением острой формы заболевания [1,2,4,6].…”

Section: Discussionunclassified

“…Это проявилось в снижении доли лиц, инфицированных при инъекционном употреблении наркотических средств и при внутрибольничном заражении, а также в увеличении доли лиц, заражение которых произошло посредством полового и контактно-бытового путей передачи [2]. Группой риска гепатита С в настоящее время в РФ являются лица наиболее трудоспособного возраста 20-39 лет [3,6].…”

Section: Discussionunclassified

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Features of the course of manifest forms of acute hepatitis C

et al. 2018

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Aim. To identify clinical, epidemiological and laboratory-instrumental features of acute hepatitis C at the present stage according to the infectious hospital data. Methods. The study included 111 patients with acute hepatitis C aged from 18 to 79 years who were hospitalized in Republican Clinical Infectious Diseases Hospital named after A.F. Agafonov in 2011 - I quarter of 2017. Acute hepatitis C was diagnosed in accordance with the guidelines of the Ministry of Health of the Russian Federation. Results. In the study group, females aged 21 to 40 years, non-working, predominantly living in Kazan with medical transmission of infection (34 %) prevailed. The disease was mild and moderately severe (71 %). The icteric form was observed in 94 % of patients, in 3.6 % - with a cholestatic component. When comparing laboratory parameters, markers of cytolysis and cholestasis differed significantly in patients depending on the severity (p<0.001). Changes in the gallbladder walls (an ultrasound marker of cholestasis) were revealed in 21.4 % of patients. On specific examination, the viral RNA was detected in 100 % of patients. Analysis of serological markers revealed predominance of antibodies to core and NS3 proteins, M class antibodies were detected only in half of the patients. Specific antibodies were absent (“dark diagnostic window”) in 3 % of patients with mild and 6 % of moderate form of the disease. Conclusion. The feature of the course of acute viral hepatitis C was the predominance of moderate forms (71 %) with medical transmission of infection. Icteric forms of acute viral hepatitis C were diagnosed in 94 % of patients (in 3.6 % cases with the development of cholestatic component). PCR is a mandatory method of specific diagnosis of acute viral hepatitis C, and in case of a “dark diagnostic window” becomes the leading method.

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Features of the course of manifest forms of acute hepatitis C

et al. 2018

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“…В связи с преимущественно скрытым течением, высокой уязвимостью отдель ных социальных групп и низкой доступностью противовирусной терапии продолжается рост числа инфицированных [20]. Важность изуче ния эпидемиологии ХГС в России обусловлена высоким уровнем заболеваемости, ростом числа вирусоносителей, изменением структуры путей передачи возбудителей, а также возрастной структуры заболеваемости с преобладанием лиц трудоспособного возраста [21,22] В период с 1997 по 2018 г. в Самарской облас ти отмечалось периодическое волнообразное уве личение заболеваемости ХГС с небольшими снижениями показателей. В период с 1997 по 2016 г. наблюдался рост заболеваемости ХГС с 5,2 0 / 0000 до 58,0 0 / 0000 , т. е. в 11,16 раза (p < 0,01).…”

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Epidemiological Situation of Chronic Hepatitis C Virus Infection in Russia and the Samara Region

Чурбакова¹,

Акимкин²,

Павлов³

et al. 2020

PH&LE

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Introduction: The ongoing adverse situation with the prevalence of chronic hepatitis C virus (HCV) infection makes it especially relevant to assess the epidemiological situation of this infection in the country as a whole and the Samara Region. Our objective was to determine characteristics of the epidemic process of chronic HCV infection in the territory of the Russian Federation and the Samara Region in 1997–2018. Results and discussion: We observed a dynamic 5.88-fold increase in the Russian rates of chronic HCV infection in 1997–2014 from 6.7 0/0000 to 39.4 0/0000 (p < 0.01) followed by a decrease by 16.5 % in 2015–2018 (from 39.2 0/0000 to 32.7 0/0000). In the Samara Region, we traced a periodic wave-like increase alternating with small drops in the prevalence rates during the whole observation period. In 1997–2016, the rates of chronic HCV infection rose from 5.2 0/0000 to 58.0 0/0000 (by 11.2 times; p < 0.01) and declined slightly from 58.0 0/0000 to 56.2 0/0000 in 2016–2018. The maximum rates of chronic HCV infection in the child population of the Samara Region were registered in 2002 and 2012 (7.1 0/0000 and 7.2 0/0000, respectively) with the minimum of 1.9 0/0000 noted in 2017. The analysis of the epidemiological situation of chronic hepatitis is important for subsequent trend forecasting and developing appropriate preventive measures.

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Metabolic activity of neutrophils and monocytes in the peripheral blood at the viral hepatitis C

Цховребов¹,

Tskhovrebov²,

Плахтий³

et al. 2015

Vladikavkaz Medico-Biological Bulletin

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Survey of 67 patients with viral hepatitis C was made. Of these comorbidities were identified in 11 patients. The survey was conducted at the height of clinical manifestations, in the waning of clinical symptoms in early convalescence. The control group consisted of 27 healthy individuals. In patients with hepatitis C dysfunction of neutrophils and monocyteswas revealed. These changescorrelate with the severity of the process. A consequence of the metabolic defect is a decrease in phagocytic activity of neutrophils and monocytes, which allows to offer methods of studying the metabolism of peripheral blood phagocytes as additional criteria to assess the severity of the disease, the prognosis of viral Hepatitis C, its outcomes and complications.

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Epidemiological Features of Hepatitis C Virus Infection in the Russian Federation in 1994–2013

Cited by 8 publications

References 4 publications

Features of the course of manifest forms of acute hepatitis C

Features of the course of manifest forms of acute hepatitis C

Epidemiological Situation of Chronic Hepatitis C Virus Infection in Russia and the Samara Region

Metabolic activity of neutrophils and monocytes in the peripheral blood at the viral hepatitis C

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