Epidemiological features and viral shedding in children with SARS‐CoV‐2 infection

Hua, Chun Zhen; Miao, Ziping; Zheng, Ji Shan; Huang, Qian; Sun, Qing; Hong, Lu; Su, Fei; Wang, Wei Hong; Huang, Lie Ping; Chen, Daqing; Xu, Zhi; Ji, Le Dan; Zhang, Hong Ping; Yang, Xiao; Li, Ming Hui; Mao, Yuan; Ying, Man Zhen; Ye, Sheng; Shu, Qiang; Chen, En Fu; Liang, Jian Feng; Wang, Wei; Chen, Zhi Min; Li, Wei; Fu, Jun

doi:10.1002/jmv.26180

Cited by 83 publications

(111 citation statements)

References 25 publications

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“…Additionally, 71.2% (52/73) were still positive for fecal nucleic acid after the respiratory tract specimens turned negative, 45.2% (33/73) were fecal nucleic acid-positive one week after the respiratory tract specimen was nucleic acid-negative, and 34.2% (25/73) were fecal nucleic acid-positive two weeks after a respiratory tract nucleic acid negative test. A study from Anhui Province in China found that the longest interval between the respiratory tract specimen turning negative and fecal specimen turning negative exceeded 70 days 34 . However, in a study on three neonates 27 , respiratory tract and fecal nucleic acid tests were positive 2 and 4 days after birth, respectively, and the fecal and respiratory tract specimens were negative on the 6th day after birth.…”

Section: Resultsmentioning

confidence: 99%

Gastrointestinal symptoms and fecal nucleic acid testing of children with 2019 coronavirus disease: a systematic review and meta-analysis

Wang

Cui

Tang

et al. 2020

Sci Rep

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In order to understand the clinical manifestations and incidence of gastrointestinal symptoms of coronavirus disease (COVID-19) in children and discuss the importance of fecal nucleic acid testing.We retrospectively analyzed studies on gastrointestinal symptoms and fecal nucleic acid detection in pediatric COVID-19 patients from January 1, 2020 to August 10, 2020, including prospective clinical studies and case reports. The results of fecal nucleic acid detection were analyzed systematically. Stata12.0 software was used for meta-analysis.The results showed that the most common gastrointestinal symptoms in children with COVID-19 were vomiting and diarrhea, with a total incidence of 17.7% (95% Cl 13.9–21.5%). However, the prevalence of gastrointestinal symptoms in other countries (21.1%, 95% CI 16.5–25.7%) was higher compared to China (12.9%, 95% CI 8–17.7%). In Wuhan, the pooled prevalence was much higher (41.3%, 95% CI 3.2–79.4%) compared to areas outside Wuhan in China (7.1%, 95% CI 4.0–10.3%). The positive rate of fecal nucleic acid testing in COVID-19 children was relatively high at 85.8% (91/106). Additionally, 71.2% (52/73) were still positive for fecal nucleic acid after respiratory tract specimens turned negative. One and two weeks after the respiratory tract specimens turned nucleic acid-negative, 45.2% (33/73) and 34.2% (25/73) patients, respectively, remained fecal nucleic acid-positive. The longest interval between the respiratory tract specimens turning negative and fecal specimens turning negative exceeded 70 days. Conclusions and relevance: gastrointestinal symptoms in pediatric COVID-19 are relatively common. Attention should be paid to the detection of fecal nucleic acids in children. Fecal nucleic acid-negative status should be considered as one of the desegregation standards.

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Section: Resultsmentioning

confidence: 99%

Gastrointestinal symptoms and fecal nucleic acid testing of children with 2019 coronavirus disease: a systematic review and meta-analysis

Wang

Cui

Tang

et al. 2020

Sci Rep

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“…The coronavirus disease-19 (COVID-19) pandemic is an ongoing world crisis. This pandemic has taken a toll on human health and has also placed a huge burden on economies, societies, and families across the globe (Carter et al, 2020;Cutler, 2020;Donthu and Gustafsson, 2020;Hua et al, 2020;Jenson, 2020;Mclaren et al, 2020;Ornell et al, 2020;Power, 2020;Satiani et al, 2020). This COVID-19 crisis is further deepened because the future of countries, societies, and individuals is uncertain and unpredictable in the months and perhaps years to come.…”

Section: Introductionmentioning

confidence: 99%

Intervention and Improved Well-Being of Basic Science Researchers During the COVID 19 Era: A Case Study

et al. 2020

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“…Starting from December 2019, a novel coronavirus (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has spread on a global scale [ 1 ]. Compared to adults, children seem to be less affected by SARS-CoV-2 infection as they are usually asymptomatic or have mild symptoms [ [1] , [2] , [3] , [4] ]. However, little is known about disease severity in neonates, the need for treatment and their role in transmission of SARS-CoV-2 [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, in children aged between 2 months and 15 years, SARS-CoV-2 RNA could still be detected in their stool in up to 70 days [ 4 , 8 , 9 ]. Data about duration of viral shedding in neonates is scarce [ 10 , 24 , 27 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding

Slaats¹,

Versteylen²,

Gast³

et al. 2020

Journal of Infection and Public Health

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Background SARS-CoV-2 has spread globally. Currently, literature of SARS-CoV-2 in neonates is scarce. We present a case of a neonate with a high viral load and prolonged virus shedding. Methods Epidemiology, clinical characteristics, treatment, laboratory data and follow-up information and the treatment of a neonate with COVID-19 were recorded. Results A 7-day-old boy was admitted to the hospital with fever, lethargy and apnoea. He was found SARS-CoV-2 RNA positive with an exceptionally high viral load in nasopharyngeal swab and stool. The father and two maternity nurses at home had detectable SARS-CoV-2 RNA as well. Sequencing showed all strains belonged to the same cluster. The father was asymptomatic and the maternity nurses developed symptoms after visiting. In the mother, no SARS-CoV-2 RNA could be found. Six days after admission, the neonate was discharged after clinical improvement with oral antibiotics because of a possible pyelonephritis. Monitoring the course of this infection showed that SARS-CoV-2 RNA was detectable in the nasopharynx until day 19 and in stool until day 42 after symptom onset. Conclusions This case shows that neonates can have a high viral load of SARS-CoV-2 and can shed the virus for over one month in stool. Despite the high viral load in the neonate, the mother and a sibling did not get infected.

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Epidemiological features and viral shedding in children with SARS‐CoV‐2 infection

Cited by 83 publications

References 25 publications

Gastrointestinal symptoms and fecal nucleic acid testing of children with 2019 coronavirus disease: a systematic review and meta-analysis

Gastrointestinal symptoms and fecal nucleic acid testing of children with 2019 coronavirus disease: a systematic review and meta-analysis

Intervention and Improved Well-Being of Basic Science Researchers During the COVID 19 Era: A Case Study

Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding

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