Epidemiological factors associated with treated incidence of first‐episode non‐affective psychosis in Cantabria: insights from the Clinical Programme on Early Phases of Psychosis

Pelayo-Terán, José María; Pérez-Iglesias, Rocí­o; Ramírez-Bonilla, Mariluz; González‐Blanch, César; Martínez-Garcia, Obdulia; Pardo-García, Gema; Rodríguez-Sánchez, José Manuel; Roiz-Santiáñez, Roberto; Tordesillas‐Gutiérrez, Diana; Mata, Ignacio; Vázquez‐Barquero, José Luís; Crespo‐Facorro, Benedicto

doi:10.1111/j.1751-7893.2008.00074.x

Cited by 134 publications

(78 citation statements)

References 44 publications

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“…There were no biases in the way patients were referred and the age-corrected (15e50) incidence rate for schizophrenia spectrum disorder was 1.38 per 10,000. A more detailed description of our program has been previously reported (Pelayo-Teran et al, 2008). The Mental Health Services of Cantabria provided funding for implementing the program.…”

Section: Study Setting and Financial Supportmentioning

confidence: 99%

Predicting relapse after a first episode of non-affective psychosis: A three-year follow-up study

Caseiro

Pérez-Iglesias

Mata

et al. 2012

Journal of Psychiatric Research

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123

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Section: Study Setting and Financial Supportmentioning

confidence: 99%

Predicting relapse after a first episode of non-affective psychosis: A three-year follow-up study

Caseiro

Pérez-Iglesias

Mata

et al. 2012

Journal of Psychiatric Research

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123

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“…A detailed description of our program has been previously reported (Pelayo-Teran et al, 2008). Other MRI studies have been written based on PAFIP program.…”

Section: Subjectsmentioning

confidence: 99%

“…Data for the present investigation were obtained from an ongoing epidemiological and three-years longitudinal intervention program of first-episode psychosis (PAFIP) conducted at the outpatient clinic and the inpatient unit at the University Hospital Marques de Valdecilla, Spain (Pelayo-Teran et al, 2008). Conforming to international standards for research ethics, this program was approved by the local institutional review board.…”

Section: Study Setting and Financial Supportmentioning

confidence: 99%

A cross-sectional and longitudinal structural magnetic resonance imaging study of the post-central gyrus in first-episode schizophrenia patients

Ferro

Roiz-Santiáñez

Foz

et al. 2015

Psychiatry Research: Neuroimaging

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“…Data for the present investigation were obtained from an ongoing epidemiological and 3-year longitudinal intervention program of first-episode non-affective psychosis [29] conducted at the University Hospital Marqués de Valdecilla, Cantabria, Spain. This program was approved by the local institutional review board and conformed to international standards for research ethics.…”

Section: Methodsmentioning

confidence: 99%

Progressive Structural Brain Changes and NRG1 Gene Variants in First-Episode Nonaffective Psychosis

et al. 2015

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Background: Structural brain abnormalities are already present during the early phases of psychosis, but factors underlying brain volume changes are still not well understood. The neuregulin 1 gene (NRG1), influencing neurodevelopment and neuroplasticity, has been associated with schizophrenia. Our aim was to examine whether variations in the NRG1 gene (SNP8NRG221132, SNP8NRG6221533 and SNP8NRG243177 polymorphisms) influence longitudinal changes in the brain during a first episode of psychosis (FEP). Methods: A 3-year follow-up magnetic resonance imaging (MRI) study was performed. Fifty-nine minimally medicated patients who were experiencing FEP and 14 healthy control individuals underwent genotyping and structural brain MRI at baseline and at 1- and 3-year follow-up. A comparison of brain volumes, gray matter, white matter (WM), lateral ventricles (LV), cortical cerebrospinal fluid, and thalamus and caudate was made between the groups according to their genotype. Results: In patients, the SNP8NRG6221533 risk C allele was significantly associated with increased LV volume across time. C allele carriers had significantly less WM compared with subjects homozygous for the T allele after the follow-up. No other significant differences were observed among subgroups. No significant changes according to the genotypes were found in healthy individuals. Conclusion: Our findings suggest that variations of neurodevelopment-related genes, such as the NRG1 gene, can contribute to brain abnormalities described in early phases of schizophrenia and progressive changes during the initial years of the illness. To our knowledge, it is the first time that a relation between NRG1 polymorphisms and longitudinal brain changes is reported.

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Epidemiological factors associated with treated incidence of first‐episode non‐affective psychosis in Cantabria: insights from the Clinical Programme on Early Phases of Psychosis

Abstract: The reported factors suggest that underlying biological and social factors modulate the risk of psychosis. This balance operates differently in males and females.

Cited by 134 publications

References 44 publications

Predicting relapse after a first episode of non-affective psychosis: A three-year follow-up study

Predicting relapse after a first episode of non-affective psychosis: A three-year follow-up study

A cross-sectional and longitudinal structural magnetic resonance imaging study of the post-central gyrus in first-episode schizophrenia patients

Progressive Structural Brain Changes and NRG1 Gene Variants in First-Episode Nonaffective Psychosis

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