Epidemiological differences for cutaneous melanoma in a relatively dark-skinned caucasian population with chronic sun exposure

Lasithiotakis, Konstantinos; Krüger‐Krasagakis, Sabine; Ioannidou, Despoina; I, Pediaditis; Tosca, Androniki

doi:10.1016/j.ejca.2004.06.032

Cited by 24 publications

(49 citation statements)

References 29 publications

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“…Similar to our findings, other case-control studies, particularly those of Mediterranean populations, have failed to show a definite risk influence of sunburns on melanoma [13,[29][30][31] supporting the notion that the latitude of the country, as well as other phenotypic factors, i.e., ''resistant'' skin phenotype to UV-induced erythema, or even behavioral aspects, i.e., individuals exhibiting a more cautious approach due to year-round sunlight exposure, play an important role in strengthening or attenuating this association [23].…”

Section: Discussionsupporting

confidence: 93%

“…In contrast to the results of the study from Crete [13] and others [29], we were not able to establish an independent association between actinic keratoses and melanoma, even though the presence of AK was a statistically significant risk factor in the univariate analysis. Actinic keratoses are markers of cumulative chronic sun exposure and are more common in fair skinned individuals with a history of high lifetime or occupational exposure.…”

Section: Discussioncontrasting

confidence: 85%

“…In fact, the presence of solar lentigenes was an important risk factor in our analysis increasing the likelihood of melanoma by a factor of 4.3. A positive association between solar lentigenes and melanoma risk has been reported from Southern Greece [13] as well from studies of Central and Southern Europe [9,27,28]. It is unclear how the presence of lentigenes correlates with melanoma risk, but probably relates to a tendency of melanocytic stimulation under the effect of cumulative or intermittent sun exposure [26].…”

Section: Discussionmentioning

confidence: 94%

“…Investigation of the precise set of risk factors of melanoma in Greece would be intriguing, taking in consideration the high year-round ambient UV exposure and the significant portion of individuals with a darker, ''sun-protective'' skin complexion. With the exception of one case/control study in a defined geographic area of Southern Europe (Crete) [13], only sparse data exist on the phenotypic or environmental risk factors of the Greek population. Our case/control study, the largest reported so far from Greece, aimed to explore the associations of the disease with phenotypic and solar indices in a ''low incidence'' Southern European population.…”

Section: Introductionmentioning

confidence: 99%

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Risk associations of melanoma in a Southern European population: results of a case/control study

Nikolaou

Sypsa

Stefanaki

et al. 2008

Cancer Causes Control

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 85%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Risk associations of melanoma in a Southern European population: results of a case/control study

Nikolaou

Sypsa

Stefanaki

et al. 2008

Cancer Causes Control

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“…[1][2][3][4] This increase might be associated with changing sun exposure patterns, although many other melanoma risk factors might be implicated. Genetic factors, environmental factors, vitamin D, the use of sunscreens, and latitude are determining agents for melanoma occurrence.…”

Section: Introductionmentioning

confidence: 99%

Development of a three-dimensional surface imaging system for melanocytic skin lesion evaluation

et al. 2013

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Abstract. Even though surface morphology is always taken into account when assessing clinically pigmented skin lesions, it is not captured by most modern imaging systems using digital imaging. Our aim is to develop a novel three-dimensional (3D) imaging technique to record detailed information of the surface anatomy of melanocytic lesions that will enable improved classification through digital imaging. The apparatus consists of three highresolution cameras, a light source, and accompanying software. Volume measurements of specific phantoms using volumetric tubes render slightly lower values than those obtained by our 3D imaging system (mean% AE SD, 3.8% AE 0.98, P < 0.05). To examine the reproducibility of the method, sequential imaging of melanocytic lesions is carried out. The mean% AE SD differences of area, major axis length, volume, and maximum height are 2.1% AE 1.1, 0.9% AE 0.8, 3.8% AE 2.9, and 2.5% AE 3.5, respectively. Thirty melanocytic lesions are assessed, including common and dysplastic nevi and melanomas. There is a significant difference between nevi and melanomas in terms of variance in height and boundary asymmetry (P < 0.001). Moreover, dysplastic nevi have significantly higher variances in pigment density values than common nevi (P < 0.001). Preliminary data suggest that our instrument has great potential in the evaluation of the melanocytic lesions. However, these findings should be confirmed in larger-scale studies.

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The incidence and mortality of cutaneous melanoma in southern Germany

Lasithiotakis

Leiter

Gorkievicz

et al. 2006

Cancer

126

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BACKGROUND Cutaneous melanoma (CM) incidence and mortality have risen dramatically during the past 2 generations, particularly among Caucasian populations. Detailed, long‐term trends of CM in relation to clinical and pathologic characteristics in a Central European population have not been published to date. METHODS The current study was based on 1980 patients with invasive CM diagnosed in Southern Germany during the years from 1976 to 2003 documented by the Central Malignant Melanoma Registry. The German standard population was used to calculate age‐standardized rates, and the annual percent change was estimated by using age, anatomic site, histologic type, and tumor thickness. RESULTS During the study period, the incidence of CM approximately was tripled for males and females, reaching 10.3 and 13.3 per 100,000 per year, respectively (P < .001). The largest increases occurred for melanoma localized on the upper limbs (annual change, 5.9% for males and 5.0% for females; P < .001) and superficially spreading melanoma (annual change, 7.8% for males and 5.9% for females; P < .001). Thin tumors (Breslow thickness <1 mm) were presented significantly more often during the study period (annual change, 9.8% for males and 6.1% for females; P < .001), predominantly in younger patients. Thick tumors and nodular melanomas were more frequent among older patients (age >70 years), particularly among males. The age‐standardized mortality decreased from 1.5 to 0.8 per 100,000 males and from 2.6 to 0.8 per 100,000 females with a significant downward trend for the female population (P < .001). CONCLUSIONS The current results indicated which diverging trends between incidence and mortality may be explained by improved public awareness regarding suspicious pigmented lesions and the earlier detection of these tumors. Continuation of the current preventive strategy and its expansion to include older age groups in the population are warranted. Cancer 2006. © 2006 American Cancer Society.

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Epidemiological differences for cutaneous melanoma in a relatively dark-skinned caucasian population with chronic sun exposure

Cited by 24 publications

References 29 publications

Risk associations of melanoma in a Southern European population: results of a case/control study

Risk associations of melanoma in a Southern European population: results of a case/control study

Development of a three-dimensional surface imaging system for melanocytic skin lesion evaluation

The incidence and mortality of cutaneous melanoma in southern Germany

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