Epidemiological correlates between consumption of Indian chewing tobacco and oral cancer

Goud, M. L.; Mohapatra, S C; Mohapatra, Pradyumna K.; Gaur, Smriti; Pant, G. C.; Knanna, M. N.

doi:10.1007/bf00145797

Cited by 22 publications

(11 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar changes (increase in ND and reduction in CD) observed in the buccal cells exposed to the habit of tobacco chewing suggest that this habit may be related to the development of oral pre-malignant and malignant lesions. These results tend to support the findings of epidemiological studies (5,9) that tobacco chewing is a causative factor for oral cancer. The betel quid contains, in addition to tobacco, other ingredients such as the betel leaf, areca nut and lime.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

The effect of tobacco smoking and of betel chewing with tobacco on the buccal mucosa: a cytomorphometric analysis

Ramaesh

Mendis

Ratnatunga

et al. 1999

J Oral Pathology Medicine

View full text Add to dashboard Cite

The effect of tobacco use on the buccal mucosa has been assessed by cytomor‐phometry. Cell and nuclear diameters (CD, ND) of exfoliated oral squames were measured in tobacco smokers (S), betel chewers with tobacco (C) and those with a combined habit (S + C). Non‐users (NU) served as controls. The mean CD values in S, C, S + C and NU were: 50.8 (± 0.47), 49.39 (± 0.48), 49.12 (±0.47) and 51.87 (± 0.76) urn, and the mean ND values were: 8.83 (± 0.07), 8.61 (± 0.08), 8.72 (± 0.10) and 8.33 (± 0.09) um, respectively. The least significant difference procedure (LSD at P= 0.05) showed a significant reduction for CD in C and S + C and an increase for ND in all three habit groups, compared to the controls. This study shows that the use of tobacco influences the cytomorphology of the normal buccal mucosa. Betel chewing with tobacco influences the ND and CD, while smoking influences only the ND.

show abstract

Section: Discussionsupporting

confidence: 88%

“…The common forms of smoking habits in Sri Lanka are cigarettes and bidi. Bidi is a crude form of cheap cigarette, made of a special grade (less refined) of (4)(5)(6)(7)(8).…”

mentioning

confidence: 99%

The effect of tobacco smoking and of betel chewing with tobacco on the buccal mucosa: a cytomorphometric analysis

Ramaesh

Mendis

Ratnatunga

et al. 1999

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…Reasons for exclusion of studies from meta-analysis [66] were: retrospective hospital based review [69] , [70] ; adjusted OR and statistical analyses were not clearly stated or it was not possible to compute the effect estimate from the information given [54] , [71] – [73] ; and the sample size of a case-control study was less than 50 [58] . Further cohort studies which reported hazard ratio as an expression of mortality rate from oral cancer were also excluded [34] , [35] , [74] .…”

Section: Resultsmentioning

confidence: 99%

Systematic Review and Meta-Analysis of Association of Smokeless Tobacco and of Betel Quid without Tobacco with Incidence of Oral Cancer in South Asia and the Pacific

2014

View full text Add to dashboard Cite

AimThis systematic review and meta-analysis aimed to critically appraised data from comparable studies leading to quantitative assessment of any independent association between use of oral smokeless tobacco in any form, of betel quid without tobacco and of areca nut with incidence of oral cancer in South Asia and the Pacific.MethodsStudies (case control and/or cohort) were identified by searching Pub Med, CINAHL and Cochrane databases through June 2013 using the keywords oral cancer: chewing tobacco; smokeless tobacco; betel quid; betel quid without tobacco; areca nut; Asia, the Pacific and the reference lists of retrieved articles. A random effects model was used to compute adjusted summary ORRE for the main effect of these habits along with their corresponding 95% confidence intervals. To quantify the impact of between-study heterogeneity on adjusted main-effect summary ORRE, Higgins' H and I2 statistics along with their 95% uncertainty intervals were used. Funnel plots and Egger's test were used to evaluate publication bias.ResultsMeta-analysis of fifteen case–control studies (4,553 cases; 8,632 controls) and four cohort studies (15,342) which met our inclusion criteria showed that chewing tobacco is significantly and independently associated with an increased risk of squamous-cell carcinoma of the oral cavity (adjusted main-effect summary for case- control studies ORRE = 7.46; 95% CI = 5.86–9.50, P<0.001), (adjusted main-effect summary for cohort studies RR = 5.48; 95% CI = 2.56–11.71, P<0.001). Furthermore, meta-analysis of fifteen case control studies (4,648 cases; 7,847 controls) has shown betel quid without tobacco to have an independent positive association with oral cancer, with OR = 2.82 (95% CI = 2.35–3.40, P<0.001). This is presumably due to the carcinogenicity of areca nut. There was no significant publication bias.ConclusionThere is convincing evidence that smokeless (aka chewing) tobacco, often used as a component of betel quid, and betel quid without tobacco, are both strong and independent risk factors for oral cancer in these populations. However, studies with better separation of the types of tobacco and the ways in which it is used, and studies with sufficient power to quantify dose-response relationships are still needed.

show abstract

“…It was no longer a significant risk factor (as was true for wine use) when adjusted with age. Given the other health hazards associated with snuff such as oral cancer, 37,38 efforts to decrease its use in the population should be encouraged.…”

Section: Discussionmentioning

confidence: 99%

Hypertension and its determinants among adults in high mountain villages of the Northern Areas of Pakistan

et al. 2001

View full text Add to dashboard Cite

We studied the prevalence and determinants of hypertension among adults in mountainous rural villages in the Ghizar district Northern Areas of Pakistan, an area that recently has undergone substantial economic development. We selected a stratified random sample of 4203 adults (age Ͼ18 years) from 16 villages in Punial Valley of Ghizar district where the number of study subjects from each village was proportionate to the size of the village. We obtained blood pressure (BP) records by taking the mean of the second and third BP measurement, using a standard mercury sphygmomanometer, and assessed risk factors for hypertension in the study subjects. The mean ؎ s.

show abstract

Epidemiological correlates between consumption of Indian chewing tobacco and oral cancer

Cited by 22 publications

References 3 publications

The effect of tobacco smoking and of betel chewing with tobacco on the buccal mucosa: a cytomorphometric analysis

The effect of tobacco smoking and of betel chewing with tobacco on the buccal mucosa: a cytomorphometric analysis

Systematic Review and Meta-Analysis of Association of Smokeless Tobacco and of Betel Quid without Tobacco with Incidence of Oral Cancer in South Asia and the Pacific

Hypertension and its determinants among adults in high mountain villages of the Northern Areas of Pakistan

Contact Info

Product

Resources

About