Epidemiological, clinical and radiological aspects of osteopoikilosis

Benli, I. Teoman; Akalın, Serdar; Boysan, Ersan; Mumcu, EF; Kis, Mahmut; Turkoglu, D

doi:10.1302/0301-620x.74b4.1624505

Cited by 126 publications

(87 citation statements)

References 5 publications

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“…3,4 In an epidemiological study of familial Osteopoikilosis by Benli et al a predominance of these lesions was found in the phalanges of hand (100%) followed by carpal bones (97.4%), metacarpals (92.3%), foot phalanges (87.2%), metatarsals (84.4%), tarsal bones (84.6%), pelvis (74.4%), radius (66.7%), ulna (66.7%), sacrum (58.9%), humerus (28.2%), tibia (20.5%) and fibula (12.8%). 5 On serial radiographs these sclerotic may show an increase or decrease in size or number with occasional disappearance in children, in sharp contrast with adults in whom these lesions remain more or less static. 1 Differential considerations for this abnormality include osteoblastic metastases, tuberous sclerosis and mastocytosis.…”

Section: Discussionmentioning

confidence: 99%

Osteopoikilosis – Spotted bone disease

Negi

Manchanda

Sanga

et al. 2013

Medical Journal Armed Forces India

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Section: Discussionmentioning

confidence: 99%

Osteopoikilosis – Spotted bone disease

Negi

Manchanda

Sanga

et al. 2013

Medical Journal Armed Forces India

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“…O estudo com radiofármacos específi-cos para osso não mostra atividade aumentada nas áreas com as alterações ósseas (4) . Histologicamente, as áreas escleróticas são condensações focais de osso compacto lamelar dentro da esponjosa (1) . Os achados microscópicos das lesões são idênti-cos aos encontrados nas ilhotas ósseas.…”

Section: Discussionunclassified

“…A osteopoiquilose é uma displasia osteosclerótica, assintomática, também conhecida como osteopatia condensante disseminada ou doença do osso manchado (1) . Descrita no início do século por Stieda, Albers-Schönberg e Ledoux-Lebard, costuma ser um achado radiológico em investigação de doença concomitante (2) .…”

Section: Introductionunclassified

Osteopoiquilose: apresentação de um caso e revisão da literatura

2002

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Os autores relatam o caso de uma paciente portadora do HIV e tuberculose pulmonar, na qual foram obOs autores relatam o caso de uma paciente portadora do HIV e tuberculose pulmonar, na qual foram obOs autores relatam o caso de uma paciente portadora do HIV e tuberculose pulmonar, na qual foram obOs autores relatam o caso de uma paciente portadora do HIV e tuberculose pulmonar, na qual foram obOs autores relatam o caso de uma paciente portadora do HIV e tuberculose pulmonar, na qual foram observadas servadas servadas servadas servadas alterações ósseas compatíveis com osteopoiquilose. A osteopoiquilose foi diagnosticada por acaso.alterações ósseas compatíveis com osteopoiquilose. A osteopoiquilose foi diagnosticada por acaso. alterações ósseas compatíveis com osteopoiquilose. A osteopoiquilose foi diagnosticada por acaso. alterações ósseas compatíveis com osteopoiquilose. A osteopoiquilose foi diagnosticada por acaso. alterações ósseas compatíveis com osteopoiquilose. A osteopoiquilose foi diagnosticada por acaso. São mostradas imagens do estudo por radiologia convencional e tomografia computadorizada, e breve revisão São mostradas imagens do estudo por radiologia convencional e tomografia computadorizada, e breve revisão São mostradas imagens do estudo por radiologia convencional e tomografia computadorizada, e breve revisão São mostradas imagens do estudo por radiologia convencional e tomografia computadorizada, e breve revisão São mostradas imagens do estudo por radiologia convencional e tomografia computadorizada, e breve revisão da literatura. Que seja do nosso conhecimento, trata-se do primeiro relato desta associação de doenças. da literatura. Que seja do nosso conhecimento, trata-se do primeiro relato desta associação de doenças. da literatura. Que seja do nosso conhecimento, trata-se do primeiro relato desta associação de doenças. da literatura. Que seja do nosso conhecimento, trata-se do primeiro relato desta associação de doenças. da literatura. Que seja do nosso conhecimento, trata-se do primeiro relato desta associação de doenças. Unitermos: Osteopoiquilose. HIV. Radiologia.Osteopoikilosis -a case report and review of the literature. The authors report a case of osteopoikilosis in a woman with HIV infection and pulmonary tuberculosis, and The authors report a case of osteopoikilosis in a woman with HIV infection and pulmonary tuberculosis, and The authors report a case of osteopoikilosis in a woman with HIV infection and pulmonary tuberculosis, and The authors report a case of osteopoikilosis in a woman with HIV infection and pulmonary tuberculosis, and The authors report a case of osteopoikilosis in a woman with HIV infection and pulmonary tuberculosis, and bone abnormalities suggestive of osteopoikilosis. The diagnosis of osteopoikilosis was incidental. Plain bone abnormalities suggestive of osteopoikilosis. The diagnosis of osteopoikilosis was incidental. Plain bone abnormalities suggestive of osteopoikilosis. The diagnosis of osteopoikilosis was incidental. Plain bone abnormalities suggestive of ...

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“…Osteopoikilosis exists in hereditary (autosomal dominant transmission) and sporadic forms [4][5][6][7] and is one of several bone dysplasias characterized by defective endochondral bone formation.…”

Section: 3mentioning

confidence: 99%

“…2 The lesions have been described in all age groups, and although prevalence studies have shown a higher frequency among men, the apparently unequal sex distribution may be a result of referral bias in the literature (men are more likely than women to present to hospital with traumatic injuries requiring radiologic investigation). 2,3 Osteopoikilosis exists in hereditary (autosomal dominant transmission) and sporadic forms [4][5][6][7] and is one of several bone dysplasias characterized by defective endochondral bone formation. 5 Endochondral ossification refers to the formation of the long and flat bones, which begins from a primitive hyaline cartilaginous model.…”

mentioning

confidence: 99%

Benign spotted bones: a diagnostic dilemma

Primio¹

2011

Canadian Medical Association Journal

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A young woman presented to the emergency department with acute knee pain after a minor fall. Radiographs showed no evidence of fracture or joint effusion, but scattered periarticular sclerotic foci of variable size were noted in the femur and tibia (Figure 1). These lesions were re cognized by the radiologist as typical for osteopoikilosis.S potted bones associated with benign conditions can have a very typical radiographic appearance and distribution; however, ambiguity in this appearance or a history of malignant disease can lead to diagnostic uncertainty and the need for further investigation. This clinical primer will focus on one characteristic benign condition, osteopoikilosis, its relevant differential diagnosis and workup.Osteopoikilosis was first described in 1915 by Albers-Schönberg as a sclerosing bone dysplasia of unknown cause.1 It is also referred to as spotted bones or osteopathia condensans disseminata. A diagnosis of exclusion, cases may be underreported. Prevalence in the general population is unknown, but an older retrospective review reported an estimated prevalence of 1 in 50 000. 2 The lesions have been described in all age groups, and although prevalence studies have shown a higher frequency among men, the apparently unequal sex distribution may be a result of referral bias in the literature (men are more likely than women to present to hospital with traumatic injuries requiring radiologic investigation). 2,3Osteopoikilosis exists in hereditary (autosomal dominant transmission) and sporadic forms [4][5][6][7] and is one of several bone dysplasias characterized by defective endochondral bone formation.5 Endochondral ossification refers to the formation of the long and flat bones, which begins from a primitive hyaline cartilaginous model. This process is in contrast to intramembranous ossification, which refers to direct transformation of condensed mesenchymal cells into cortical bone without a cartilaginous phase, as is typically seen in the formation of the skull bones. 5Most reported cases of osteopoikilosis are identified during the investigation of unrelated problems in which there is no clinical history suggestive of either malignant or systemic disease. 8,9 In such situations, no further workup is necessary. The characteristic radiologic feature is multiple, punctate, sclerotic, round or oval foci symmetrically distributed in a predominantly periarticular fashion within the epiphyseal and metaphyseal regions. 8,9 In the three patients described in this issue, most of the sclerotic foci are 1-2 mm, although some lesions measure up to 10 mm. Although further investigation is unnecessary in typical osteopoikilosis, when radionuclide bone scans are performed, their results are negative. In clinical and radiologic follow-up of osteopoikilosis, the lesions remain stable.Osteopoikilosis is typically an asymptomatic incidental finding, but it can be associated with other diseases. Most importantly, it must be differentiated from sclerotic metastases and other sclerosing dyplasias. • Osteopoik...

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Epidemiological, clinical and radiological aspects of osteopoikilosis

Cited by 126 publications

References 5 publications

Osteopoikilosis – Spotted bone disease

Osteopoikilosis – Spotted bone disease

Osteopoiquilose: apresentação de um caso e revisão da literatura

Benign spotted bones: a diagnostic dilemma

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