Epidemiological, clinical and laboratory features of chronic hepatitis B infection in a cohort of immigrant and Italian patients from Ferrara, Italy

Contini, Carlo; Badia, Lorenzo; Cultrera, Rosario; Grilli, Anastasio; Togni, Aldo De

doi:10.1016/s1665-2681(19)31411-5

Cited by 12 publications

(12 citation statements)

References 17 publications

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“…In contrast, HBV infection is rarely observed in Asian immigrants (16)(17)(18). These data, showing the differences in infection rates due to ethnicity, highlight the epidemiological pattern of the prevalence of HBV based on country of origin (13,(19)(20)(21). Among our participants, more than half had CHB, indication of a previous infection, with a clear majority from Sub-Saharan Africa (10/12 patients).…”

Section: Discussionsupporting

confidence: 57%

Screening for infectious diseases in newly arrived asymptomatic immigrants in southern Italy

Scotto

Fazio

Muzio

et al. 2019

East Mediterr Health J

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Background: Screenings for infectious diseases in asymptomatic immigrants currently takes place when receiving new arrivals. Aims: We describe the frequency of infections in a cohort of newly arrived asymptomatic immigrants in Southern Italy. Methods: We studied a cohort of 238 Sub-Saharan African and Asian men hosted at a reception centre (CARA) in Foggia between January and December 2015. The tuberculin skin test for diagnosis of latent tuberculosis infection (LTBI) and serology/virology testing for HBV, HCV, HIV were performed. Results: From this cohort, 205 individuals agreed to be tested for serological/virological markers only, while 82 agreed to be tested for LTBI only; 49 people agreed to have both tests. Among those tested for virological markers, 23/205 (11.2%) were HBsAg positive; 12/23 (52.2%) individuals had chronic active hepatitis; 77/205 (37.6%) individuals had only anti-HBc positivity. HCV infection was present in 8/205 (3.9%) individuals, and chronic HCV infection, was diagnosed in only two people. Only 2/205 (1.0%) individuals presented with anti-HIV and HIV-RNA positivity. We found LTBI in 29.6% of TB-tested individuals. Conclusions: Asymptomatic immigrants are at increased risk for some infections, mainly HBV and tuberculosis.

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Section: Discussionsupporting

confidence: 57%

Screening for infectious diseases in newly arrived asymptomatic immigrants in southern Italy

Scotto

Fazio

Muzio

et al. 2019

East Mediterr Health J

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“…However, since 2007 no further decrease in HDV prevalence was recorded in Italy, with steady prevalence rates of 8.4% among HBsAg carriers (28). Of note, the reported prevalence of HDV infection was lower, ranging from 1.3 to 5.0% in Italians and from 4.7 to 7.9% in immigrants, in studies providing data from limited geographic regions (29,30). Unlike several HDV prevalence studies in Italy, the data on HDV prevalence in the other three countries bordering Slovenia are scant and outdated because they date back to 1985, 1993, and 1994, respectively (31)(32)(33).…”

Section: Discussionmentioning

confidence: 98%

“…To evaluate whether differences in HDV prevalence across European countries could be at least partially attributed to the use of anti-HDV antibody tests with different analytical characteristics (mainly different analytical specificity), the material and methods sections of published studies (Table 2) were carefully analyzed. Out of 36 eligible studies, the commercially available enzymelinked immunosorbent assay ETI-AB-DELTAK-2 (DiaSorin) was used in nine studies (14,16,19,30,(37)(38)(39)(40)(41) and the Abbott anti-HD radioimmunoassay (Abbott Laboratories, Chicago, IL) and Radim anti-HDVAb (Radim Iberica, Barcelona, Spain) were used in one study each (17,29). Unfortunately, tests used for detecting anti-HDV antibodies were not specified in the majority of eligible studies.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis D virus infection in Slovenian patients with chronic hepatitis B virus infection: a national prevalence study and literature review

Jelen

Hošnjak

Stunf

et al. 2016

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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“…This shows the infectivity potential of HBV carriers infected by (sub)genotypes circulating in endemic regions like East Asia, Africa, Alaska and East Europe [133] . In a recent investigation in Italy, the immigrant population (mostly from Eastern European countries) showed a high prevalence of HBeAg-positivity with a mean age of 31 years [148] . In another study, Dervicevic et al [149] showed the integration of exotic genotypes of HBV with HBeAg-positivity and high viral load among antenatal women in the United Kingdom.…”

Section: Effect Of "Immigro-subgenotype" On Clinical Outcomementioning

confidence: 99%

Molecular identification of hepatitis B virus genotypes/subgenotypes: Revised classification hurdles and updated resolutions

Pourkarim¹

2014

WJG

163

177

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The clinical course of infections with the hepatitis B virus (HBV) substantially varies between individuals, as a consequence of a complex interplay between viral, host, environmental and other factors. Due to the high genetic variability of HBV, the virus can be categorized into different HBV genotypes and subgenotypes, which considerably differ with respect to geographical distribution, transmission routes, disease progression, responses to antiviral therapy or vaccination, and clinical outcome measures such as cirrhosis or hepatocellular carcinoma. However, HBV (sub)genotyping has caused some controversies in the past due to misclassifications and incorrect interpretations of different genotyping methods. Thus, an accurate, holistic and dynamic classification system is essential. In this review article, we aimed at highlighting potential pitfalls in genetic and phylogenetic analyses of HBV and suggest novel terms for HBV classification. Analyzing full-length genome sequences when classifying genotypes and subgenotypes is the foremost prerequisite of this classification system. Careful attention must be paid to all aspects of phylogenetic analysis, such as bootstrapping values and meeting the necessary thresholds for (sub)genotyping. Quasi-subgenotype refers to subgenotypes that were incorrectly suggested to be novel. As many of these strains were misclassified due to genetic differences resulting from recombination, we propose the term "recombino-subgenotype". Moreover, immigration is an important confounding facet of global HBV distribution and substantially changes the geographic pattern of HBV (sub)genotypes. We therefore suggest the term "immigro-subgenotype" to distinguish exotic (sub)genotypes from native ones. We are strongly convinced that applying these two proposed terms in HBV classification will help harmonize this rapidly progressing field and allow for improved prophylaxis, diagnosis and treatment.

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Epidemiological, clinical and laboratory features of chronic hepatitis B infection in a cohort of immigrant and Italian patients from Ferrara, Italy

Cited by 12 publications

References 17 publications

Screening for infectious diseases in newly arrived asymptomatic immigrants in southern Italy

Screening for infectious diseases in newly arrived asymptomatic immigrants in southern Italy

Hepatitis D virus infection in Slovenian patients with chronic hepatitis B virus infection: a national prevalence study and literature review

Molecular identification of hepatitis B virus genotypes/subgenotypes: Revised classification hurdles and updated resolutions

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