Epidemiological Aspects of Multiple Sclerosis: A Comparative Study of Four Centres in Europe

Prange, A. J. A.; Lauer, Klaus; Poser, S.; Minderhoud, Janna; Firnhaber, W; Dassel, H; Bauer, Hélène

doi:10.1159/000110816

Cited by 14 publications

(9 citation statements)

References 1 publication

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Relative to findings on adult MS in Germany, this study revealed similar frequencies of symptoms at primary manifestation, with the exception of a higher frequency of cerebellar symptoms and a lower frequency of pyramidal symptoms [22]. In accordance with these findings, a study has just been published in which cerebellar and brainstem symptoms were reported to be the most frequent initial presentation of paediatric MS, appearing significantly more frequently in paediatric MS patients than in a control adult onset MS population [27].…”

Section: Discussionsupporting

confidence: 85%

Paediatric multiple sclerosis and acute disseminated encephalomyelitis in Germany: results of a nationwide survey

et al. 2007

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 85%

Paediatric multiple sclerosis and acute disseminated encephalomyelitis in Germany: results of a nationwide survey

et al. 2007

View full text Add to dashboard Cite

show abstract

“…These values are also homogeneous with the mean values demonstrated by the multi center study sponsored by the SIN during the years 1971-1980, especially if we exclude the particularly high value found in Sardinia, where the disease has peaked in recent years [45][46][47]. j li We feel that our study, currently the largest-scale survey carried out in Italy, is a fur ther and useful contribution to defining the frequency and clinical characteristics of the disease [48,49] in nonisolated genetically comparable zones of Italy.…”

Section: Discussionmentioning

confidence: 53%

Epidemiological Survey of Multiple Sclerosis in the Provinces of Reggio Emilia and Modena, Italy

Guidetti

Cavalletti²,

Merelli³

et al. 1995

Neuroepidemiology

View full text Add to dashboard Cite

We present the results of an epidemiological survey on MS conducted in the provinces of Reggio Emilia and Modena (4,980 km²) from 1970 to 1990. The population increased from 943,182 residents in 1970 to 1,024,223 in 1990, with an average population during the period of the survey of 993,056. The mean annual incidence was 1.59 cases/100,000 inhabitants (c.i. 95% 1.42–1.78). The prevalence as of December 31, 1990, was 39.44/100,000 inhabitants. Our study is a further demonstration that Italy is a high-risk zone for this disease, and also demonstrates the possibility of carrying out reliable epidemiological surveys even over extensive territories.

show abstract

“…The distribution of disease severity in The Netherlands was not reported in the study by Minderhoud and Zwanniken [4], but an earlier estimate in the same region reported a severity distribution according to the Expanded Disability Status Scale (EDSS) [6] of 43 with mild disease (EDSS scores of 0-3.5), 18 with moderate disease (EDSS scores of 4.0-6.5) and 39 with severe disease (EDSS scores of 7 and above) [7]. The recent European average estimate by Pugliatti and colleagues [5] set these proportions around 45-55 for mild disease (published range 33-80) and 20 to 30 for moderate and 15 to 20 for severe disease (ranges, 13-48 and 5-39, respectively), and this may be indicative of a likely trend towards earlier diagnosis.…”

Section: Al In This Supplement)mentioning

confidence: 99%

Costs and quality of life in multiple sclerosis in The Netherlands

Kobelt

Berg²,

Lindgren³

et al. 2006

Eur J Health Econ

View full text Add to dashboard Cite

This cost-of-illness analysis based on information from 1.549 patients in The Netherlands is part of a Europe-wide study on the costs of multiple sclerosis (MS). The objective was to analyze the costs and quality of life (QOL) related to the level of disease severity and progression. Patients from three specialized MS centres participated in the survey by answering a mail questionnaire (response rate, 52%). In addition to details on the disease (type of disease, relapses, level of functional disability), the questionnaire asked for information on all resource consumption, medical, non-medical, work absence, early retirement and informal care as well as QOL (expressed as utility). The mean age of the cohort was 47 years, and 7.6% of patients were 65 years of age or more. Forty-eight percent of patients had mild disease [Expanded Disability Status Scale (EDSS) score of 0-3], 40% moderate disease (EDSS score of 4-6.5) and 11% severe disease (EDSS score of 7 and above). The mean EDSS score in the sample was 3.9 (median 4.0), with a utility of 0.61. Costs and utility are highly correlated with disease severity. Workforce participation decreases from around 75 to 80% in early disease to less than 5% in the very late stages. Hospitalization is very infrequent in early disease, representing less than euro 500 per year for patients at EDSS scores below 6, but increases steeply for patients at an EDSS score of 7 and above. Ambulatory care increases fivefold between early and late disease, while services rise from basically no cost to almost euro 8.000 per year at an EDSS score of 7 and euro 19.000 per year at EDSS scores of 8-9. Productivity losses are multiplied by 10 in late disease, while informal care increases from euro 300 per year at EDSS scores of 0-1 to nearly euro 15.000 per year at EDSS scores of 8-9. Hence, total mean costs per patient are driven essentially by the distribution of the severity levels in the sample, increasing from euro 9.300 per year at EDSS scores of 0-1 to euro 50.000 per year at an EDSS score of 7 and euro 78.000 per year at EDSS scores of 8-9. The same is true for utility, which decreases from 0.85 to 0.05 as the disease becomes severe. However, the utility loss compared to the age- and gender-matched general population is high at all levels of the disease (0.25 at an EDSS score of 2 to 0.4 at EDSS scores of 5-6), leading to an estimated annual loss of 0.24 quality-adjusted life-years (QALYs) per patient. Relapses for patients with an EDSS score below 5 are associated with a cost of around euro 2.800 and a utility loss of 0.15 during the quarter in which they occur.

show abstract

Epidemiological Aspects of Multiple Sclerosis: A Comparative Study of Four Centres in Europe

Cited by 14 publications

References 1 publication

Paediatric multiple sclerosis and acute disseminated encephalomyelitis in Germany: results of a nationwide survey

Paediatric multiple sclerosis and acute disseminated encephalomyelitis in Germany: results of a nationwide survey

Epidemiological Survey of Multiple Sclerosis in the Provinces of Reggio Emilia and Modena, Italy

Costs and quality of life in multiple sclerosis in The Netherlands

Contact Info

Product

Resources

About