Epidemiological and histopathological analysis of 40 apocrine sweat gland carcinomas in dogs: a retrospective study

Kycko, Anna; Jasik, Agnieszka; Bocian, Łukasz; Otrocka-Domagała, Iwona; Mikiewicz, Mateusz; Śmiech, Anna; Łopuszyński, Wojciech; Dolka, I.; Nowak, Marcin; Madej, Janusz A.

doi:10.1515/jvetres-2016-0050

Cited by 3 publications

(5 citation statements)

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“…Most of the studies seem to agree on at-risk breeds, study in United Kingdom (UK Kennel Club) recognized breeds reports cancer incidence is the highest in some types like the Irish water spaniel, followed by Rottweiler, Bull terrier, Welsh terrier, Giant schnauzer and other types [16]. While anther study was found the highest number of the cancer cases was diagnosed in Terrier breed dogs (30%) and German Shepherds (25%) [17] which confirmed our findings . In this study mainly dogs were working with military forces (army and police) (70%), and just (30%) were pet dogs , this may expose them to chemical material like (TNT, C4, drugs and other carcinogenic materials ) which was highly threat to public health and life of dogs.…”

Section: Discussionsupporting

confidence: 87%

Clinical and Histopathological Study on Dog's Tumors in Iraq

2017

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The study was conducted on twenty dogs from variety breeds to estimate the incidence of tumor mass and determine the risk factors of survey to cases of a year in veterinary hospital in Baghdad. The most common clinical signs were, ulceration, bleeding into lesions in addition to drowsiness, anorexia, fever and the others were depended tumor's location in dog's body like lameness, lacrimation and bloody constipation etc.The results showed 70% of the infected dogs were working with military forces and 30% of them were pet dogs and we found that the highest percentage of tumor accrued in dogs aged more than 10 years and the females recorded 60% of infection.Terrier breed had the highest percentage of infection (30%) followed by German shepherd (25%). the most tumor affected part of the body were mammary glands in females and the limbs in both gender (25% each one) and followed by the other sites, the histopathology picture had recorded seven types of malignant tumors in (skin, intestine and mammary glands) more frequent was Sequmas cell carcinoma 35% Adenocarcinoma 20%. Some dogs had more than one type of cancer, and some cases had recorded of benign tumors other cases had only transformed tissue but not cancer. Keywords ISSN: 0067-2904Alabbody et al. Science, 2017, Vol. 58, No.3C, pp: 1617 Iraqi Journal of IntroductionCancers in dogs occur naturally, so it is one of the best cancer model for human and cancer studies, because these tumor are various, infect the aged and obese, otherwise dogs live in the same environment so exposed to same carcinogens. Dogs are greater resembling humans biologically, such as (telomere and telomerase actions) in addition to common spontaneous epithelial cancer [1, 2], many anatomic and clinical resemble are seamed such as type and subtypes of cancer between the two species, and same treatment schemes [3].Cancer is the chief cause of death in dogs over 10 years in aged , with 50% of older dogs developing the disease and approximately one in four dogs eventually dying from it. [4] The primary studies to natural dog tumors could be for developing the knowledge about human cancers [5]. All breeds, both sex and all ages are able to infect with cancer but there are variables. Multiple cancers are common to find in some breeds, in other side, there is specific cancer for specific breed. Histiocytic cancer covers a broad range of clinical appearances, from benign cutaneous histiocytoma to highly aggressive histiocytic sarcoma (HS). HS is a multisystem disease with tumors appearing at the same time like the skin or subcutis, or other organs. This is a virulent and fatal disorder of dendritic cell origin [6].Cancer incidence of dogs is rising. Invert of other animals, the good health care of pets lead to early correct diagnosis of cancer, more cure because owners are ready to pay for diagnostic tests and treatment. Veterinary epidemiologists get better their ability to track canine cancer. Scientists are more work to know which breeds are at an increased risk of each type of cancer. ...

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Section: Discussionsupporting

confidence: 87%

Clinical and Histopathological Study on Dog's Tumors in Iraq

2017

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“…This is certainly associated with the impact of various carcinogenic factors in a given geographical area. To date, few studies have addressed the epidemiology of canine skin tumours in Poland and generally they have reported the frequency of neoplastic skin lesions or presented research on the histological types of skin tumours ( 17 , 26 ). In the available world literature, there are no epidemiological analyses of the risk of malignant versus benign canine skin tumours with reference to the breed, age or sex of dogs or tumours’ anatomical locations; such analyses may nevertheless be an important source of information in tumour prognosis.…”

Section: Introductionmentioning

confidence: 99%

Incidence and the risk of occurrence of benign and malignant canine skin tumours in Poland – a five-year retrospective study

Śmiech,

Bulak,

Łopuszyński

et al. 2023

Journal of Veterinary Research

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Introduction The aim of the study was to compile data on the frequency and distribution of canine skin tumours and determine the risk of these being malignant as opposed to benign. This determination proceeded from tumour histogenesis and gave consideration to the dog’s breed, sex, age and the anatomical location of tumours. Material and Methods This retrospective five-year epidemiological study included 3,139 canine skin tumours collected in Poland. A univariable logistic regression analysis was performed to determine the odds ratios (ORs) with 95% confidence intervals (CIs). Results Microscopic analysis showed a significant predominance of benign tumours (65.02%) as well as mesenchymal and melanocytic tumours (59.57%). The most frequently diagnosed were mast cell tumours, accounting for 13.79% of all skin tumours, and other common tumour types were lipomas (6.40%), haemangiopericytomas (5.96%) and malignant melanomas (4.65%). The risk of malignant versus benign tumours was 1.212 times higher in the female than in the male dogs. A higher risk of development of malignant epithelial tumours was found in boxers (OR 4.091), German shepherds (OR 4.085) and flat-coated retrievers (OR 43.596). A higher risk of development of malignant mesenchymal tumours was found in golden retrievers (OR 4.693), boxers (OR 2.342), bulldogs (OR 3.469) and Maltese (OR 2.757). Conclusions The results may serve as a reference point for further studies of the complex biology of canine skin tumours.

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“…Apocrine sweat gland carcinomas (ASGCs) are rare malignant skin tumours which represent approximately 0.7% to 2.2% of all skin neoplasms diagnosed in dogs ( 3 , 4 , 29 , 56 ). Individual cases of this type of tumour were reported in cats ( 14 , 16 , 50 ), cattle ( 54 , 61 ), horses ( 2 , 11 ) and a rabbit ( 41 ).…”

Section: Introductionmentioning

confidence: 99%

“…ASGCs are also very rare in humans, with an incidence rate estimated to range from 0.0049 to 0.0173 per 100,000 patients per year ( 17 ). In dogs, these cancers have been found to occur at older age (from 6 to 17 years) in both sexes, mainly in golden retrievers, mixed breeds and German shepherds ( 29 , 56 ). Tumours can grow anywhere on the body, but most frequently on the head, neck, thorax and limbs ( 23 , 29 , 36 , 56 ).…”

Section: Introductionmentioning

confidence: 99%

“…In dogs, these cancers have been found to occur at older age (from 6 to 17 years) in both sexes, mainly in golden retrievers, mixed breeds and German shepherds ( 29 , 56 ). Tumours can grow anywhere on the body, but most frequently on the head, neck, thorax and limbs ( 23 , 29 , 36 , 56 ). They are usually aggressive, with a tendency to local recurrence and metastasis to the regional lymph nodes, lungs, liver, bone and bone marrow via lymphatic and intravascular invasion both in humans ( 4 , 36 , 48 , 65 ) and dogs ( 3 , 19 , 22 , 42 , 56 ).…”

Section: Introductionmentioning

confidence: 99%

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Mutations of p53 gene in canine sweat gland carcinomas probably associated with UV radiation

Jasik¹,

Kycko²,

Olech³

et al. 2021

Journal of Veterinary Research

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Introduction Apocrine sweat gland carcinomas (ASGCs) are rare malignant skin tumours in dogs and humans. The literature published so far focuses mostly on the clinico-epidemiological aspect of these tumours, but little is known about their pathogenesis. In this study we aimed to determine whether the p53 gene is involved in the carcinogenesis of the apocrine sweat gland in dogs and whether ultraviolet radiation (UV) is related to it. Material and Methods Forty canine ASGCs were submitted to laser capture microdissection to isolate neoplastic cells, from which DNA was subsequently extracted. PCR amplification and sequencing of p53 exons 2–8 was then performed, followed by computer analysis of the obtained sequences. Results Sixteen mutations within the p53 gene were found in 13 tumours. The mutations involved C → T, T → C, G → A, and CC → TT transitions, C → G transversion and adenine deletion, which are gene alteration types known to be related to UV radiation in the process of skin carcinogenesis in humans. Six of the thirteen tumour cases displayed the C → T transitions in the same location in exon 4 and three of the thirteen cases displayed T → C in the same location in exon 5. Conclusion The results of the present study indicate both the participation of the p53 gene and the influence of UV radiation in the formation of ASGCs in dogs.

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Epidemiological and histopathological analysis of 40 apocrine sweat gland carcinomas in dogs: a retrospective study

Cited by 3 publications

References 14 publications

Clinical and Histopathological Study on Dog's Tumors in Iraq

Clinical and Histopathological Study on Dog's Tumors in Iraq

Incidence and the risk of occurrence of benign and malignant canine skin tumours in Poland – a five-year retrospective study

Mutations of p53 gene in canine sweat gland carcinomas probably associated with UV radiation

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