Epidemiological and Clinical Features of Three Clustered Cases Co‐Infected with Lyme Disease and Rickettsioses

Xuefei, D.; Qin, Hao; Xiaodi, G.; Zhen, Geng; Wei, Luqing; Hou, Xin; Jiazhen, G.; Xiuping, F.; Meimei, T.; Yunru, L.; Xiaoling, F.; Wan, Kanglin; Li, Xingwang

doi:10.1111/zph.12025

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…A distinct skin lesion at the location of the tick bite, known as eschar, may develop in the majority of cases with spotted fever [7] (Figure 2). Lyme disease can affect multiple systems of the body and produce a series of symptoms, including erythema migrans, fever, arthritis, neurologic and heart damage, and may continue to develop severe chronic consequences such as neurological symptoms and disability [8]. (e) -Red, oval plaque (Red, expanding oval-shaped plaque on the trunk).…”

Section: Discussionmentioning

confidence: 99%

A Case of Tick Bite Induced Babesiosis With Lyme Disease

Bhesania

Arora

Tokarski

et al. 2021

Cureus

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The Ixodes tick may transmit multiple pathogens, Lyme disease being the most common. Early detection of tick bites and using prophylaxis measures is the key to prevent tick bite-associated diseases like babesiosis, anaplasmosis, and Lyme disease. It is recommended to follow preventive measures like using diethyltoluamide (DEET) on the skin, applying permethrin on clothes while visiting the tick-infested areas. Co-infection is an uncommon occurrence but still representative in endemic areas. If there is delayed initiation of therapy in these kinds of patients, there may be dire consequences that may require aggressive therapy. Clinicians should consider co-infection when suspecting tick-borne disease which can prove to be fatal if not addressed promptly. Here, we present the case of a 72-year-old female with atypical symptoms, who was found to have coinfection with Lyme disease and Babesiosis on serology testing and peripheral smear and was diagnosed and treated promptly.

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Section: Discussionmentioning

confidence: 99%

A Case of Tick Bite Induced Babesiosis With Lyme Disease

Bhesania

Arora

Tokarski

et al. 2021

Cureus

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Mapping the risk distribution of Borrelia burgdorferi sensu lato in China from 1986 to 2020: a geospatial modelling analysis

Che

Jiang

et al. 2022

Emerging Microbes & Infections

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Lyme borreliosis, recognized as one of the most important tick-borne diseases worldwide, has been increasing in incidence and spatial extent. Currently, there are few geographic studies about the distribution of Lyme borreliosis risk across China. Here we established a nationwide database that involved Borrelia burgdorferi sensu lato ( B. burgdorferi ) detected in humans, vectors, and animals in China. The eco-environmental factors that shaped the spatial pattern of B. burgdorferi were identified by using a two-stage boosted regression tree model and the model-predicted risks were mapped. During 1986−2020, a total of 2,584 human confirmed cases were reported in 25 provinces. Borrelia burgdorferi was detected from 35 tick species with the highest positive rates in Ixodes granulatus , Hyalomma asiaticum , Ixodes persulcatus , and Haemaphysalis concinna ranging 20.1%−24.0%. Thirteen factors including woodland, NDVI, rainfed cropland, and livestock density were determined as important drivers for the probability of B. burgdorfer i occurrence based on the stage 1 model. The stage 2 model identified ten factors including temperature seasonality, NDVI, and grasslands that were the main determinants used to distinguish areas at high or low-medium risk of B. burgdorferi , interpreted as potential occurrence areas within the area projected by the stage 1 model. The projected high-risk areas were not only concentrated in high latitude areas, but also were distributed in middle and low latitude areas. These high-resolution evidence-based risk maps of B. burgdorferi was first created in China and can help as a guide to future surveillance and control and help inform disease burden and infection risk estimates.

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Case report: A patient coinfected by Borrelia burgdorferi sensu lato and spotted fever group Rickettsiae in Urumqi, China

et al. 2019

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Rationale: Both Borrelia burgdorferi sensu lato and spotted fever group Rickettsiae (SFGR) are pathogens carried by ticks. There is a possibility of co-infection with these tick-borne diseases. Patient concerns: Male patient, 63 years-of-age, admitted to hospital with skin rash presenting for 1 week and fever with cough and expectoration for 3 days before admission. Diagnoses: We diagnosed that the patient was co-infected by B burgdorferi sl and SFGR using laboratory test results and the patient's clinical manifestations. Interventions: The patient started therapy with oral minocycline, then levofloxacin by intravenous injection for SFGR. Meanwhile, he was treated with penicillin G sodium, cefoperazone sulbactam sodium and ceftriaxone by intravenous injection for B burgdorferi sl. Outcomes: After the patient was in stable condition, he was discharged from hospital. Lessons: This case report highlights the possibility of co-infection by 2 tick-borne diseases in Urumqi, Xinjiang Uygur Autonomous Region, China. The antibiotic therapy should be based on the detection of pathogenic bacteria, and the different susceptibilities of co-infecting bacteria should be considered.

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Epidemiological and Clinical Features of Three Clustered Cases Co‐Infected with Lyme Disease and Rickettsioses

Cited by 3 publications

References 22 publications

A Case of Tick Bite Induced Babesiosis With Lyme Disease

A Case of Tick Bite Induced Babesiosis With Lyme Disease

Mapping the risk distribution of Borrelia burgdorferi sensu lato in China from 1986 to 2020: a geospatial modelling analysis

Case report: A patient coinfected by Borrelia burgdorferi sensu lato and spotted fever group Rickettsiae in Urumqi, China

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