Epidemiologic Trend Changes in Acute Renal Failure—A Tertiary Center Experience from South India

Jayakumar, M; Prabahar, Murugesan Ram; Fernando, Edwin; Rajendran, Manorajan; Venkatraman, R.; Balaraman, Vasanthi

doi:10.1080/08860220600689034

Cited by 77 publications

(56 citation statements)

References 11 publications

(15 reference statements)

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“…Whereas in developed regions elderly patients predominate (4,5), in developing countries, AKI is a disease of the young (14,17,18) and children (19,20), in whom volume-responsive "prerenal" mechanisms are common (21)(22)(23)(24). Although overall mortality seems to be lower than in developed countries (25)(26)(27)(28), this finding is not true across all age groups: In these regions, AKI affects predominantly the young and children and mortality is high (29,30).…”

mentioning

confidence: 99%

Epidemiology of Acute Kidney Injury

Cerdá¹,

Lameire²,

Eggers³

et al. 2008

Clinical Journal of the American Society of Nephrology

243

156

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Background and objectives: The worldwide incidence of acute kidney injury is poorly known because of underreporting, regional disparities, and differences in definition and case mix. New definitions call for revision of the problem with unified criteria.Design, setting, participants, & measurements: This article reports on the research recommendations of an international multidisciplinary committee, assembled to define a research agenda on acute kidney injury epidemiology using a modified three-step Delphi process.Results: Knowledge of incidence and risk factors is crucial because it drives local and international efforts on detection and treatment. Also, notable differences exist between developing and developed countries: Incidence seems higher in the former, but underreporting compounded by age and gender disparities makes available data unreliable. In developing countries, incidence varies seasonally; incidence peaks cause critical shortages in medical and nursing personnel. Finally, in developing countries, lack of systematic evaluation of the role of falciparum malaria, obstetric mechanisms, and hemolytic uremic syndrome on acute kidney injury hampers efforts to prevent acute kidney injury.Conclusions: The committee concluded that epidemiologic studies should include (1) prospective out-and inpatient studies that measure incidence of community and hospital acute kidney injury and post-acute kidney injury chronic kidney disease; (2) incidence measurements during seasonal peaks in developing and developed countries; and (3) whenever available, use of reliable existing administrative or institutional databases. Epidemiologic studies using standardized definitions in community and institutional settings in developing and underdeveloped countries are essential first steps to achieving early detection and intervention and improved patient outcomes.

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mentioning

confidence: 99%

Epidemiology of Acute Kidney Injury

Cerdá¹,

Lameire²,

Eggers³

et al. 2008

Clinical Journal of the American Society of Nephrology

243

156

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“…[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] The 15 studies incorporated patient series ranging from 20 to 1095 AKI patients each, mean age 39-65 years, and the rates of SORO-ESRD revealed from our analysis in the 15 independent reports demonstrated SORO-ESRD rates from 1% in some series, up to 85% of the AKI series. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] AKI was commonly precipitated by hypovolemia/hypotension, infections/sepsis and exposure to nephrotoxics especially radiocontrast, NSAIDs, aminoglycosides and RAAS blocking agents, ACEIs and ARBs. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] …”

Section: Resultsmentioning

confidence: 99%

“…[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] AKI was commonly precipitated by hypovolemia/hypotension, infections/sepsis and exposure to nephrotoxics especially radiocontrast, NSAIDs, aminoglycosides and RAAS blocking agents, ACEIs and ARBs. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] …”

Section: Resultsmentioning

confidence: 99%

Evidence of the syndrome of rapid onset end-stage renal disease (SORO-ESRD) in the acute kidney injury (AKI) literature – preventable causes of AKI and SORO-ESRD – a call for re-engineering of nephrology practice paradigms

Onuigbo

2013

Renal Failure

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“…42 However, clinical studies have shown that antibiotic therapy is efficient in the early and late phases of the disease. 49 Based on the recommendation of the World Health Organization of 2003, severe leptospirosis should be treated with intravenous penicillin (1,500,000 U every 6h), ceftriaxone (1g once a day), or cefotaxime (1g every 6h), all equally effective. 50,51 Antibiotic therapy should be maintained for seven days.…”

Section: Treatment Antibiotic Therapymentioning

confidence: 99%

Insuficiência renal aguda associada à leptospirose

Daher¹,

Abreu

Silva³

2010

J. Bras. Nefrol.

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Leptospirosis is the most important zoonosis in the world. Patients are typically young men. Several factors are involved in acute kidney injury (AKI) in leptospirosis, including direct nephrotoxic action of the leptospira, hyperbilirubinemia, rhabdomyolysis and hypovolemia. The major histological findings are acute interstitial nephritis and acute tubular necrosis. Leptospirosis-induced AKI is usually nonoliguric and hypokalemic. Tubular function abnormalities precede a decline in the glomerular filtration rate, which could explain the high frequency of hypokalemia. Antibiotic treatment is efficient in the early and late and/or severe phases. For critically ill leptospirosis patients, the following measures are recommended: early and daily hemodialysis; low volume infusion (due to the risk of pulmonary hemorrhage); and lung-protective strategies. Mortality in leptospirosis-associated AKI is around 22%.

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Epidemiologic Trend Changes in Acute Renal Failure—A Tertiary Center Experience from South India

Cited by 77 publications

References 11 publications

Epidemiology of Acute Kidney Injury

Epidemiology of Acute Kidney Injury

Evidence of the syndrome of rapid onset end-stage renal disease (SORO-ESRD) in the acute kidney injury (AKI) literature – preventable causes of AKI and SORO-ESRD – a call for re-engineering of nephrology practice paradigms

Insuficiência renal aguda associada à leptospirose

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