Epidemiologic Study of Malassezia Yeasts in Seborrheic Dermatitis Patients by the Analysis of 26S rDNA PCR-RFLP

Oh, Byung Ho; Lee, Yang Won; Choe, Yong Beom; Ahn, Kyu Joong

doi:10.5021/ad.2010.22.2.149

Cited by 19 publications

(9 citation statements)

References 27 publications

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“…There was no significant difference in the distribution of Malassezia species in the facial skin samples taken from SD patients and healthy controls. In a Korean population, Oh et al [21] found no significant difference in the distribution of Malassezia species between SD patients and healthy controls, following the culture of samples taken from the foreheads, cheeks and chests of 60 patients with SD and 60 healthy controls of an equivalent age. M. restricta was dominant in patients with SD (19.5%) and was similarly common in healthy controls (20.5%).…”

Section: Discussionmentioning

confidence: 97%

Identification of Malassezia species in the facial lesions of Chinese seborrhoeic dermatitis patients based on DNA sequencing

Lian

Shen

Gao

et al. 2014

Mycoses

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The genus Malassezia is important in the aetiology of facial seborrhoeic dermatitis (FSD), which is the most common clinical type. The purpose of this study was to analyse the distribution of Malassezia species in the facial lesions of Chinese seborrhoeic dermatitis (SD) patients and healthy individuals. Sixty-four isolates of Malassezia were isolated from FSD patients and 60 isolates from healthy individuals. Sequence analysis of the internal transcribed spacer (ITS) region was used to identify the isolates. The most frequently identified Malassezia species associated with FSD was M. furfur (76.56%), followed by M. sympodialis (12.50%) and M. japonica (9.38%). The most frequently isolated species in healthy individuals were M. furfur (61.67%), followed by M. sympodialis (25.00%), M. japonica (6.67%), M. globosa (3.33%), and M. obtusa (3.33%). Overall, our study revealed that while M. furfur is the predominant Malassezia species in Chinese SD patients, there is no significant difference in the distribution of Malassezia species between Chinese SD patients and healthy individuals.

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Section: Discussionmentioning

confidence: 97%

Identification of Malassezia species in the facial lesions of Chinese seborrhoeic dermatitis patients based on DNA sequencing

Lian

Shen

Gao

et al. 2014

Mycoses

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“…However, the molecular analysis of Malassezia species in SD demonstrated that M. restricta was consistently the most common282930. According to a study on the distribution of Malassezia species in the human body that used 26S rDNA polymerase chain reaction (PCR)-restriction fragment length polymorphism, M. restricta was detected dominantly in the forehead, cheeks, and chest of Korean patients with SD31. In a study involving Japanese patients with facial SD, M. globose (93.5%) and M. restricta (61.3%) were the two most commonly detected Malassezia species by using a PCR-based, non-culture dependent method18.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study

et al. 2016

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BackgroundSeborrheic dermatitis (SD) is a multifactorial disease; Malassezia species play an important role in its pathogenesis.ObjectiveWe aimed to determine whether a cream containing climbazole/piroctone olamine (C/P cream), antifungal agents with expected efficacy against Malassezia species, could improve SD symptoms.MethodsWe instructed 24 patients with mild-to-moderate SD to apply the C/P cream and emollient cream on the right and left sides of the face, respectively, every morning and evening for 4 weeks. The casual sebum level (measured with Sebumeter®; Courage & Khazaka Electronic GmbH, Germany) and the extent of erythema (measured with Mexameter®; Courage & Khazaka Electronic GmbH) on the face were measured at baseline and after 4 weeks. The minimal inhibitory concentration (MIC) was determined to demonstrate the antifungal activity of the C/P cream.ResultsThe casual sebum level and erythema were measured at week 4, and the median values demonstrated a quantitative improvement on the C/P cream-treated right side of the face compared to the emollient cream-treated left side. For the C/P cream, the MICs were 0.625, 5, 0.625, and 2.5 mg/ml for Malassezia restricta, M. globosa, M. sympodialis, and M. slooffiae, respectively.ConclusionBased on the reduced casual sebum level and extent of erythema, the antifungal activity of C/P cream against Malassezia species seems useful for the treatment of mild to moderate SD.

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“…More than 20 studies (Tables 3 to 6) have been carried out worldwide on the epidemiology of Malassezia species in cases of pityriasis versicolor, seborrheic dermatitis, atopic eczema, and psoriasis and on healthy control skin of the same individuals or skin from healthy volunteers (53,63,89,112,122,146,171,173,180,185,228,237,255,259,275,286,344,353). Results are not directly comparable between studies, as different methodologies, isolation media, and identification procedures have been employed.…”

Section: Culture-based Epidemiologymentioning

confidence: 99%

The Malassezia Genus in Skin and Systemic Diseases

et al. 2012

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SUMMARY In the last 15 years, the genus Malassezia has been a topic of intense basic research on taxonomy, physiology, biochemistry, ecology, immunology, and metabolomics. Currently, the genus encompasses 14 species. The 1996 revision of the genus resulted in seven accepted taxa: M. furfur , M. pachydermatis , M. sympodialis , M. globosa , M. obtusa , M. restricta , and M. slooffiae. In the last decade, seven new taxa isolated from healthy and lesional human and animal skin have been accepted: M. dermatis , M. japonica , M. yamatoensis , M. nana , M. caprae , M. equina , and M. cuniculi. However, forthcoming multidisciplinary research is expected to show the etiopathological relationships between these new species and skin diseases. Hitherto, basic and clinical research has established etiological links between Malassezia yeasts, pityriasis versicolor, and sepsis of neonates and immunocompromised individuals. Their role in aggravating seborrheic dermatitis, dandruff, folliculitis, and onychomycosis, though often supported by histopathological evidence and favorable antifungal therapeutic outcomes, remains under investigation. A close association between skin and Malassezia IgE binding allergens in atopic eczema has been shown, while laboratory data support a role in psoriasis exacerbations. Finally, metabolomic research resulted in the proposal of a hypothesis on the contribution of Malassezia -synthesized aryl hydrocarbon receptor (AhR) ligands to basal cell carcinoma through UV radiation-induced carcinogenesis.

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Epidemiologic Study of Malassezia Yeasts in Seborrheic Dermatitis Patients by the Analysis of 26S rDNA PCR-RFLP

Cited by 19 publications

References 27 publications

Identification of Malassezia species in the facial lesions of Chinese seborrhoeic dermatitis patients based on DNA sequencing

Identification of Malassezia species in the facial lesions of Chinese seborrhoeic dermatitis patients based on DNA sequencing

Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study

The Malassezia Genus in Skin and Systemic Diseases

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