Epidemiologic profile of juvenile-onset compared to adult-onset spondyloarthritis in a large Brazilian cohort

Duarte, Angela P.; Marques, Cláudia Diniz Lopes; Bortoluzzo, Adriana Bruscato; Gonçalves, Célio Roberto; Silva, José Antonio Braga da; Ximenes, Antônio Carlos; Bértolo, Manoel Barros; Ribeiro, Sandra Lúcia Euzébio; Keiserman, Mauro Waldemar; Skare, Thelma L.; Carneiro, Sueli; Menin, Rita; Azevedo, Valderílio Feijó; Vieira, Walber Pinto; Albuquerque, Elisa N.; Bianchi, W.; Bonfiglioli, Rubens; Campanholo, Cristiano; Carvalho, Hellen M.S.; Costa, Izaías Pereira da; Kohem, Charles Lubianca; Leite, Nocy; Lima, Sonia A.L.; Meirelles, Eduardo S.; Pereira, Ivânio Alves; Pinheiro, Marcelo Maia; Polito, Elizandra; Resende, Gustavo Gomes; Rocha, Francisco Airton Castro da; Santiago, Mittermayer Barreto; Sauma, Maria de Fátima Lobato da Cunha; Valim, Valéria; Barros, Percival Degrava Sampaio

doi:10.1016/j.rbre.2014.06.001

Cited by 7 publications

(10 citation statements)

References 17 publications

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“…Additionally, the disease severity assessed by PGA was reported to be higher among the JOSpA than the AOSpA group. A similar conclusion was derived by Jadon et al 17 and Duarte et al 18 JOSpA patients had a longer disease duration in comparison to AOSpA patients and had hip arthritis with a significantly more than that of axial arthritis (the mSASSS having a high significance level, P<0.05). This may present some inconveniences in the early diagnosis of JOSpA patients, as the axial involvement occurs at a later period of the disease duration 19 .…”

Section: Resultssupporting

confidence: 82%

“…Nonetheless, the corresponding ASDAS-CRP and ASDAS-ESR values also exhibited a notable difference between the two groups (P <0.05). However, some studies revealed a lower BASFI, ASQoL and PGA scores among JOAS patients compared to the scores among AOAS patients [15,18] . This contrasting result can be attributed to the different patient characteristics in the population sample of the studies.…”

Section: Resultsmentioning

confidence: 91%

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Comparison of Juvenile and Adult Onset Refractory Spondyloarthritis Patients Attending a Tertiary Rheumatology Clinic

Islam

2020

J. Bangladesh Coll. Phys.

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Objectives: To compare the demographic and clinical characteristics of juvenile onset refractory spondyloarthritis (JOSpA) with a group of adult-onset refractory spondyloarthritis (AOSpA) patients. Methods: In this real-life, cross-sectional study, a total of 215 SpA patients (refractory to two NSAIDs and/or DMARDs) were enrolled following ASAS classification criteria from a rheumatology center in Dhaka, Bangladesh. Based on age, the patients were divided into JOSpA group and AOSpA group for analysis. The patients' demographics, quality of life, laboratory and clinical characteristics were compared and analyzed between the two groups using chisquare and independent sample t-test. Results: Among 215 patients, 57 (53 males, 4 females) were in JOSpA group, and 158 (126 males, 32 females) were in AOSpA group. Most patients were male in both groups (P=0.02). The mean age at diagnosis for JOSpA and AOSpA were 27.68±9.5 and 40.28±10 years respectively (P=0.00), and mean age at onset of disease in JOSpA and AOSpA were 12.33±3.62 and 29.58±96.5 years respectively. The mean disease duration was 15.36±9.3 months in JOSpA compared to 10.70±7.1 months in AOSpA group (P=0.00). Sixteen (28.1%) JOSpA and 9 (5.7%) AOSpA patients were undernourished , (P=0.00). On the contrary, obesity was more prevalent in AOSpA patients (41.1%) than those in JOSpA patients (21.1%) (P=0.00). There were significant differences in mean haemoglobin (11.38±1.7 and 10.94±1.3 g/dl) (P=0.05) and mean serum creatinine (0.94±0.2 and 0.86±0.2 mg/dl) (P=0.03) levels in AOSpA and JOSpA groups respectively. HLA-B27 was done in 20 JOSpA and 61 AOSpA patients. Among them, 19 (95%) were positive in JOSpA and 55 (90.16%) were positive in AOSpA groups. Similarly, hips involvement was higher in JOSpA group 19 (33.3%) compared to the AOSpA group 21 (13.3%) (P=0.004). Significant differences were observed in mean disease activity parameters, patient global assessment (PGA) (7.86±1.2 vs 7.38±1.4, P=0.02), ASDAS-CRP (4.60±0.8 vs 4.33±0.9, P=0.05), and ASDAS-ESR (4.49±0.8 vs 4.17±1.0, P=0.02) in JOSpA and AOSpA groups respectively. The modified Stoke AS Spinal Score (mSASSS) in AOSpA group was higher (24.18±17.22) than that of JOSpA group (17.10±9.6) (P=0.00). Conclusions: In JOSpA patients, under nutrition, hip involvement, longer disease duration, uveitis, PGA, low Hb level and ASDAS-ESR disease activity scores were higher.On the contrary in AOSpA group, male gender, married subjects, obesity, higher creatinine level and mSASSS scores were higher.

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Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 91%

Comparison of Juvenile and Adult Onset Refractory Spondyloarthritis Patients Attending a Tertiary Rheumatology Clinic

Islam

2020

J. Bangladesh Coll. Phys.

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“…O'Shea [2] отметили, что эти варианты болезни отличаются между собой «как яблоки от апельсинов». Особенности течения АС, на-чавшегося в детском и взрослом возрасте, проявляются в частоте поражения энтезисов [3,6,15]. A. Adrovic et al [1] считают, что отличительные клинические призна-ки ЮАС являются энтезопатиями в области ахилловых сухожилий.…”

Section: ââåäåíèåunclassified

Ентезопатії При Анкілозивному Спондиліті, Що Почався В Дитячому Та Дорослому Віці

Polesovа

Chernyshova

Syniachenko

et al. 2022

TRAUMA

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“…Though ERA and AS show similarities in their clinical features, HLA-B27 association and some of the immune abnormalities, there are differences like higher prevalence of enthesitis and arthritis in juvenile onset SpA and a higher prevalence of IBP and uveitis in AS (23,24) Thus, we aimed to see if the monocyte response seen in these two diseases is similar or different. To study this, we analyzed the frequency of cytokine producing monocytes in peripheral blood (PB) and synovial fluid mononuclear cells (SFMC) at baseline as well as on stimulation with both exogenous and endogenous TLR ligands.…”

Section: Introductionmentioning

confidence: 99%

Patients with enthesitis related arthritis show similar monocyte function pattern as seen in adult axial spondyloarthropathy

2020

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Background: Axial SpA and Enthesitis related arthritis (ERA) patients show strong HLA-B27 association, gut dysbiosis, high toll like receptor (TLR)2 and 4 expression on monocytes, pro-inflammatory cytokine production and elevated levels of TLR4 endogenous ligands [tenascin-c (TNC) and myeloid related protein (MRP)8/14] in serum. Hence, we aimed to understand if these diseases have similar or different monocyte response. Methods: Fifty adult axial SpA, 52 ERA patients and 25 healthy controls (HC) were enrolled. Cytokine-producing monocyte frequency before and after stimulation with lipopolysaccharide (LPS), peptidoglycan (PG), TNC or MRP8 were measured in whole blood (WB) and synovial fluid mononuclear cells (SFMC) by flow cytometry. Also, IL-6, TNF, MMP3, TNC and MRP8/14 levels were measured in unstimulated and TLR ligand stimulated WB cultures supernatant by ELISA. Finally, the mRNA expression levels of TNF and IL-6 were measured post stimulation with LPS, TNC and MRP8. Results: At baseline, ERA and axial SpA patients showed similar TNF-α producing monocyte frequency which was higher than HC. MRP8 simulation led to increased TNF-α producing monocyte frequency in ERA than axial SpA. TNC and MRP8 stimulation led to similar IL-6 producing monocyte frequency in axial SpA and ERA patients. Baseline TNF and IL-6 producing monocyte frequency also modestly correlated with disease activity scores. TNF and IL-6 producing monocyte frequency increased in response to TLR stimulation in SFMC from both patients. In culture supernatants, axial SpA and ERA patients showed similar TNF production at baseline. MRP8 and TNC stimulation led to higher TNF production from ERA. Baseline IL-6 and MMP3 production was higher in ERA while TLR stimulation led to similar IL-6 and MMP3 production from axial SpA and ERA. TNC stimulation led to higher MMP3 production in ERA. mRNA expression in response to TLR stimulation was observed to be similar in axial SpA and ERA. TNC production was higher in ERA at baseline, while MRP8/14 production was higher in axial SpA than ERA post stimulation. Conclusion: ERA patients have similar monocyte response to exogenous and endogenous TLR ligands as patients with axial SpA. This suggests that differences between pediatric and adult-onset SpA are minimal and they may have a common pathogenesis.

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Epidemiologic profile of juvenile-onset compared to adult-onset spondyloarthritis in a large Brazilian cohort

Cited by 7 publications

References 17 publications

Comparison of Juvenile and Adult Onset Refractory Spondyloarthritis Patients Attending a Tertiary Rheumatology Clinic

Comparison of Juvenile and Adult Onset Refractory Spondyloarthritis Patients Attending a Tertiary Rheumatology Clinic

Ентезопатії При Анкілозивному Спондиліті, Що Почався В Дитячому Та Дорослому Віці

Patients with enthesitis related arthritis show similar monocyte function pattern as seen in adult axial spondyloarthropathy

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