Epidemiologic Burden of Skin Cancer in the US and Worldwide

Rundle, Chandler W.; Militello, Michelle; Barber, Cara; Presley, Colby L.; Rietcheck, Hope R; Dellavalle, Robert P.

doi:10.1007/s13671-020-00311-4

Cited by 14 publications

(6 citation statements)

References 42 publications

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“… 25 It might be the result of increasing awareness of physical examination, access to healthcare and screening methods, cumulative intense and complex sunlight exposure. 26–28 In terms of sex differences, men were usually more likely to be exposed in sunlight than women due to the different social conditions. In addition, women pay more attention to skin maintenance and protection against sunburn.…”

Section: Discussionmentioning

confidence: 99%

Incidence Trends and Survival Prediction of Malignant Skin Cancer: A SEER-Based Study

Zhu¹,

Sun²,

Zhang³

et al. 2022

IJGM

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Purpose This study aimed to analyze the incidence trend and further explore the risk factors influencing the survival among patients of malignant skin cancer in America. Methods Age-adjusted incidence rates, annual percentage change (APC) of different sex and ethnicity in 1973–2015 and patient records were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate analysis and multivariate Cox regression were used to analyze risk factors influencing the survival in skin cancer patients. Survival curves and nomograms were constructed to evaluate the survival prediction by R. Results The overall age-adjusted incidence of skin cancer increased in America from 1973 to 2005 (APC = 2.8%, 95% CI: 2.6–2.9%, P < 0.05), particularly in white patients, 66-year-old people, and males. The 3- and 5-year overall survival (OS) rates were 51.4% and 33.8%, respectively. Independent predictors for short OS include age over 65, white ethnicity, other marital status and no surgery (P < 0.05). Stage was not an independent factor of survival (P > 0.05). The nomogram with a C-index of 0.72 (95% CI: 0.71–0.73) matched an appropriate calibration curve. Conclusion Incidence of skin cancer in America was on the rise during 1973–2015 based on SEER database. Age, ethnicity, marital status and surgical history were related with survival of malignant skin cancer. Nomograms were effective tools for predicting the survival prognosis.

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Section: Discussionmentioning

confidence: 99%

Incidence Trends and Survival Prediction of Malignant Skin Cancer: A SEER-Based Study

Zhu¹,

Sun²,

Zhang³

et al. 2022

IJGM

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“…But the main effect of this ultraviolet irradiation is the increase in oxidative stress caused by the increase in ROS, which can lead to an imbalance in the endogenous antioxidant system ( Gegotek et al, 2020 ). Ultraviolet irradiation is also the main etiologic factor in the development of skin cancers ( Rundle et al, 2020 ). Phytochemicals can modulate the behaviour of tumour cells by acting on different pathways of molecular signalling such as exogenous antioxidant system.…”

Section: Introductionmentioning

confidence: 99%

Polypodium vulgare L. (Polypodiaceae) as a Source of Bioactive Compounds: Polyphenolic Profile, Cytotoxicity and Cytoprotective Properties in Different Cell Lines

et al. 2021

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Pteridophytes, represented by ferns and allies, are an important phytogenetic bridge between lower and higher plants. Ferns have evolved independently of any other species in the plant kingdom being its secondary metabolism a reservoir of phytochemicals characteristic of this taxon. The study of the potential uses of Polypodium vulgare L. (Polypodiaceae) as medicinal plant has increased in recent years particularly when in 2008 the European Medicines Agency published a monograph about the rhizome of this species. Our objective is to provide scientific knowledge on the polar constituents extracted from the fronds of P. vulgare, one of the main ferns of European distribution, to contribute to the validation of certain traditional uses. Specifically, we have characterized the methanolic extract of P. vulgare fronds (PVM) by HPLC-DAD and investigated its potential cytotoxicity, phototoxicity, ROS production and protective effects against oxidative stress by using in vitro methods. The 3T3, HaCaT, HeLa, HepG2, MCF-7 and A549 were the cell lines used to evaluate the possible cytotoxic behaviour of the PVM. HPLC-DAD was utilized to validate the polyphenolic profile of the extract. H2O2 and UVA were the prooxidant agents to induce oxidative stress by different conditions in 3T3 and HaCaT cell lines. Antioxidant activity of in vitro PVM in 3T3 and HaCaT cell lines was evaluated by ROS assay. Our results demonstrate that PVM contains significant amounts of shikimic acid together with caffeoylquinic acid derivatives and flavonoids such as epicatechin and catechin; PVM is not cytotoxic at physiological concentrations against the different cell lines, showing cytoprotective and cellular repair activity in 3T3 fibroblast cells. This biological activity could be attributed to the high content of polyphenolic compounds. The fronds of the P. vulgare are a source of polyphenolic compounds, which can be responsible for certain traditional uses like wound healing properties. In the present work, fronds of the common polypody are positioned as a candidate for pharmaceutical applications based on traditional medicine uses but also as potential food ingredients due to lack of toxicity at physiological concentrations.

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“…Skin cancer worldwide is the leading cause of skin diseases 1 . Among them, cutaneous melanoma is growing rapidly in the white population, and its incidence has been increasing by approximately 3–7% annually over the past decades 2 .…”

Section: Introductionmentioning

confidence: 99%

Antitumorigenic effect of insect-derived peptide poecilocorisin-1 in human skin cancer cells through regulation of Sp1 transcription factor

Lee

Hwang

et al. 2021

Sci Rep

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Malignant melanoma is highly resistant to conventional treatments and is one of the most aggressive types of skin cancers. Conventional cancer treatments are limited due to drug resistance, tumor selectivity, and solubility. Therefore, new treatments with fewer side effects and excellent effects should be developed. In previous studies, we have analyzed antimicrobial peptides (AMPs), which showed antibacterial and anti-inflammatory effects in insects, and some AMPs also exhibited anticancer efficacy. Anticancer peptides (ACPs) are known to have fewer side effects and high anticancer efficacy. In this study, the insect-derived peptide poecilocorisin-1 (PCC-1) did not induce toxicity in the human epithelial cell line HaCaT, but its potential as an anticancer agent was confirmed through specific effects of antiproliferation, apoptosis, and cell cycle arrest in two melanoma cell lines, SK-MEL-28 and G361. Additionally, we discovered a novel anticancer mechanism of insect-derived peptides in melanoma through the regulation of transcription factor Sp1 protein, which is overexpressed in cancer, apoptosis, and cell cycle-related proteins. Taken together, this study aims to clarify the anticancer efficacy and safety of insect-derived peptides and to present their potential as future therapeutic agents.

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Epidemiologic Burden of Skin Cancer in the US and Worldwide

Cited by 14 publications

References 42 publications

Incidence Trends and Survival Prediction of Malignant Skin Cancer: A SEER-Based Study

Incidence Trends and Survival Prediction of Malignant Skin Cancer: A SEER-Based Study

Polypodium vulgare L. (Polypodiaceae) as a Source of Bioactive Compounds: Polyphenolic Profile, Cytotoxicity and Cytoprotective Properties in Different Cell Lines

Antitumorigenic effect of insect-derived peptide poecilocorisin-1 in human skin cancer cells through regulation of Sp1 transcription factor

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