Epidemiologic and survival trends in adult primary bone tumors of the spine

Kerr, David L.; Dial, Brian; Lazarides, Alexander L.; Catanzano, Anthony A.; Lane, Whitney O.; Blazer, Dan G.; Brigman, Brian E.; Mendoza-Lattes, Sergio; Eward, William C.; Erickson, Melissa

doi:10.1016/j.spinee.2019.07.003

Cited by 42 publications

(56 citation statements)

References 23 publications

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“…[ 21 26 ] According to SEER and NCDB, the 5-year survival of chordoma is 64%–73%. [ 6 17 27 ] Higher 5-year survival (84%) also has been reported in smaller series. [ 21 ] In the current study, the mean survival time was 4.5 years which is lower than larger series like SEER (6.2 years).…”

Section: Discussionmentioning

confidence: 78%

“…The Surveillance, Epidemiology, and End Results (SEER) Registry, National Cancer Database (NCDB), National Cancer Intelligence Network, Scandinavian sarcoma group, and similar registries in other countries have been stabilized to provide large number of patients for epidemiological studies of different cancers. [ 5 6 7 8 ] Moreover, epidemiologic characteristics of each cancer should be evaluated for different populations with their own races and ethnicities separately. In light of the need to perform a similar study in the territory of Iran, a comprehensive study aimed to evaluate the epidemiologic characteristics of the mobile spine and sacrum chordoma among the Iranian population according to the Iran National Cancer Registry (INCR).…”

Section: Introductionmentioning

confidence: 99%

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Epidemiologic trend of mobile spine and sacrum chordoma: A National population-based study

Chehrassan

Ebrahimpour

Sadighi

et al. 2020

J Craniovert Jun Spine

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Introduction: Chordoma is a rare sarcoma of the axial skeleton. The incidence of this tumor is different between races. To understand the epidemiologic characteristic and due to rarity of this pathology, large number of cases should be evaluated through national data registries. Materials and Methods: All pathologically confirmed cases of chordoma were derived from the Iran National Cancer Registry. Descriptive analysis was performed to extract age-standardized and age-specific incidence rates. Data regarding tumor location and chordoma subtypes were derived and analyzed. Results: One hundred twenty-two cases of chordoma including 80 male and 42 female were identified. One hundred seven cases of nonotherwise specified chordoma, 14 chondroid chordoma, and one dedifferentiated chordoma were detected. The age-standardized incidence rate (ASIR) of chordoma was 0.28. Chordoma of the sacrum composed 67.2% of cases. The mean survival time was 4.5 years. Conclusion: Epidemiology characteristic of chordoma in Iran is similar to other studies; however, the total ASIR was lower and the incidence in sacrum is nearly twice respect to the mobile spine. While men affected by sacral chordoma in relatively older age, the female patients had higher mean age in case of mobile spine involvement. The survival rate of chordoma is significantly lower in comparison with other studies.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Epidemiologic trend of mobile spine and sacrum chordoma: A National population-based study

Chehrassan

Ebrahimpour

Sadighi

et al. 2020

J Craniovert Jun Spine

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“…(1,2) The most common histologies of these tumors include chordomas, chondrosarcomas, Ewing sarcomas, and osteosarcomas. (3) Primary spinal bone tumors with distant metastasis are a sign of advanced stage and are usually accompanied by poor prognosis. However, physicians lack experience in choosing a treatment plan and predicting prognosis because the understanding of the condition and relevant data are limited to rare cases.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Nomograms Predicting Overall and Cancer-specific Survival of Spinal and Pelvic Tumor Patients with Distant Metastasis

Zhang¹,

Tu²,

Zhou³

et al. 2020

Preprint

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Background: Primary spinal bone tumors with distant metastasis are a sign of advanced stage and are usually accompanied by poor prognosis. This study is to identify the risk factors and establish prognostic nomograms to predict 1- and 3-year overall survival (OS) and cancer-specific survival (CSS) rates for spinal and pelvic bone tumor patients with distant metastasis.Patients and methods: Spinal and pelvic bone tumor patients with distant metastasis between 1998 and 2016 were selected for this study from the Surveillance, Epidemiology, and End Results (SEER) database. Nomograms to predict 1- and 3-year OS and CCS rates were constructed based on independent risk factors identified by univariate and multivariate Cox analyses. Concordance indexes (C-indexes), receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA) were used to assess the nomograms.Results: All patients (n=343) were randomly divided into a training cohort (n=243) and validation cohort (n=100). No significant differences were found in thedemographic data of all patients in the training and validation cohorts. Ultimately, only four independent risk factors (patient age, histology, grade and surgery) were identified as significantly associated with OS and CCS. The C-indices were 0.722 (95% CI, 0.685 to 0.759) and 0.686 (95% CI, 0.61 to 0.760) for the internal validation and external validation of the OS nomogram, respectively. Similarly, the C-indices based on the CCS nomogram were 0.717 (95% CI, 0.678 to 0.757) and 0.695 (95% CI, 0.619 to 0.771) for the internal validation and external validation, respectively. The calibration curves revealed that the predicted survival and actual survival were in concordance. DCA showed the clinical utility and benefits of the nomograms.Conclusion: The nomograms we constructed based on the SEER database can accurately predict individual patient survival.

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“…According to a recently published study using the National Cancer Database (NCDB) which captures 70% of all newly diagnosed cancers, 5-year survival for spinal osteosarcoma and chondrosarcoma, two common types of primary malignant bone tumor, 3) is reported to be 38% and 69%, respectively. 4) www.krspine.org 118 Based on studies using the Surveillance, Epidemiology, and End Results (SEER) registry, surgery improves overall survival of spinal osteosarcoma, chondrosarcoma, and Ewing sarcoma. [5][6][7] The NCDB study mentioned above also reported that surgical resection and negative margin were significantly associated with improved 5-year survival in primary malignant spinal tumor patients.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7] The NCDB study mentioned above also reported that surgical resection and negative margin were significantly associated with improved 5-year survival in primary malignant spinal tumor patients. 4) However, surgical removal of these malignancies is often challenging and carries high morbidity due to the proximity of tumors to vital anatomical structures such as spinal cord and great vessels, especially when en bloc resection with a negative margin is attempted.…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Resection Type and Margin following Surgical Treatment for Primary Sarcoma of the Spine: A Multi-Center Retrospective Study

Chang

Kim

Park

et al. 2019

J Korean Soc Spine Surg

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Study Design:A retrospective multi-center study. Objectives: To analyze oncological outcomes according to the resection type and surgical margin following surgical treatment for primary spinal sarcoma. Summary of Literature Review: Previous studies using registry databases have shown that surgery and negative margins were associated with improved survival for primary spinal sarcoma. However, few studies have comprehensively analyzed the clinical significance of the resection type and surgical margin for the oncological outcomes of this rare malignancy. Materials and Methods:We retrospectively reviewed consecutive patients who underwent surgical resection for primary spinal sarcoma between 1997 and 2016 at two tertiary medical centers. Overall survival and the occurrence of local recurrence and distant metastasis were compared between the groups using Kaplan-Meier curve analysis and the log-rank test. Results: Thirty-three patients (21 males,12 females) with a mean age of 45.1 years and a median follow-up of 36 months were included. There were 13 (39.4%) chondrosarcomas, 12 (36.4%) osteosarcomas, and eight different histological diagnoses. The cohort was categorized into four groups: 1) total en bloc resection with a negative margin (n=12; 36.4%), 2) total en bloc resection with a positive margin: (n=5; 15.2%), 3) total piecemeal resection (n=12; 36.4%), and 4) subtotal resection (n=4; 12.1%). Total en bloc resection with a negative margin was associated with improved overall survival (p=0.030) and less distant metastasis (p=0.025) and local recurrence (p=0.004). Conclusions: Achieving a negative margin through total en bloc resection, although technically demanding, improves oncological outcomes in primary spinal sarcoma. 방법(일괄 및 분할)과 수술 절제연(양성 및 음성)이 생존 기간, 국소 재발 및 원격 전이 등에 미치는 영향을 생존 분석(Kaplan-Meier curve analysis and log rank test)으 로 평가하였다. 결과: 총 33명(남자 21명, 여자 12명)의 환자가 연구에 포함되었으며, 평균 나이는 45.1세, 추시 기간의 중간값은 36개월이었다. 13(39.4%)예의 연골육 종, 12(36.4%)예의 골육종이 가장 많은 조직학적 진단을 차지하였다. 전체 환자를 절제 방법 및 절제연을 기준으로 네 그룹으로 나누었을 때, 그 분포는 다음과 같았다. 1) 완전 일괄 절제 (total en bloc resection) 및 음성 절제연: n=12(36.4%), 2) 완전 일괄 절제 및 양성 절제연: n=5(15.2%), 3) 완전 분할 절 제 (total piecemeal resection): n=12(36.4%), and 4) 불완전 절제(subtotal resection): n=4(12.1%). 생존 분석을 시행하였을 때, 완전 일괄 절제 및 음성 절 제연을 시행 받은 환자들에서 유의하게 긴 생존 기간(p=0.030), 적은 원격 전이 (p=0.025) 및 국소 재발 (p=0.004)의 발생이 관찰되었다. 결론: 원발성 악성 척추 종양에서 보다 좋은 종양학적 결과(oncological outcome)를 얻기 위해서는 완전 일괄 절제술을 통해 음성 절제연을 얻고자 하는 노력이 필요하겠다. 색인 단어: 원발성 척추 종양, 일괄절제술, 생존 분석, 국소 재발, 원격 전이 약칭 제목: 원발성 척추암의 수술적 치료

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Epidemiologic and survival trends in adult primary bone tumors of the spine

Cited by 42 publications

References 23 publications

Epidemiologic trend of mobile spine and sacrum chordoma: A National population-based study

Epidemiologic trend of mobile spine and sacrum chordoma: A National population-based study

Development and Validation of Nomograms Predicting Overall and Cancer-specific Survival of Spinal and Pelvic Tumor Patients with Distant Metastasis

Clinical Significance of Resection Type and Margin following Surgical Treatment for Primary Sarcoma of the Spine: A Multi-Center Retrospective Study

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