Epidemiologic and diagnostic evaluation of a recent mumps outbreak using oral fluid samples

Molecular Epidemiological Evaluation of the Recent Resurgence in Mumps Virus Infections in Ireland

“…The relatively low percentage of oral fluid positive for IgM which was detected by the RT-PCR (ϳ35%) was not unexpected, as the presence of viral nucleic acid is largely dependent on the time of sampling and/or storage of the specimen. Indeed, the results of this study are in agreement with a previous study from this laboratory which showed that 6 of 17 IgM-positive oral fluid specimens, including both weak (6%) and strong (29%) positives, had detectable MuV RNA (ϳ35%) (22). MuV RNA was detected in ϳ44% of CSF specimens tested, and no herpesvirus DNA (HSV-1, HSV-2, VZV, or HHV-6) or enterovirus RNA was found in these specimens from patients with neurological symptoms.…”

Seroepidemiology of the recent mumps virus outbreaks in Ireland

“…However, , a shift in the peak age-specific attack rate to the 18-24 years old cohort has been observed, [9][10][11][12][13][14] however a recent historical perspective study from the CDC in Atlanta, US showed that the peak age-specific attack rates shifted in the 1993-2005 period from 5-9 years old age group to the 18-25 years old age group in 2006 and then back to 5-9 and 10-17 years age cohorts in 2007-2008. 15 In contrast to this latter report 15 of an abrupt and rapid onset of mumps outbreaks, we noted a slow progressive rise in the number of laboratory diagnosed of acute mumps cases (Fig.…”

Characterization of Large Mumps Outbreak among Vaccinated Palestinian Refugees

“…Our results demonstrate that such samples can be used to confirm the diagnosis of mumps in patients clinically presenting with parotitis but serologically negative for MuV IgM. Reid et al also recommended the usage of oral fluid samples to detect MuV RNA in nonvaccinated and partially vaccinated individuals (28).…”