Epidemiología, farmacología y caracterización clínica de la osteonecrosis de los maxilares. Un estudio retrospectivo de 70 casos

Pelaz, Alejandro; Junquera, Luís; Gallego, Lorena; Garcı́a-Consuegra, Luis; García-Martínez, Lucía; Cutilli, T; Olay, Sonsoles

doi:10.1016/j.otorri.2014.06.003

Cited by 8 publications

(1 citation statement)

References 23 publications

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“…Then, the weight of the dose deposited in the bone tissue was adjusted to the relative potency [28] (Table 2) of each bisphosphonate with the following formula [29]:…”

Section: Methodsmentioning

confidence: 99%

Pharmacoepidemiology and clinical characteristics of medication-related osteonecrosis of the jaw

Son

Kim

2019

Maxillofac Plast Reconstr Surg

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Background The aim of this study was to investigate clinical and pharmacoepidemiologic characteristics of medication-related osteonecrosis of the jaw. Methods The study population is comprised of 86patients who were diagnosed with ONJ at Ewha Womans University Mokdong Hospital from 2008 to 2015. Factors for epidemiologic evaluation were gender, age, location of lesion, and clinical history. The types of bisphosphonates, duration of intake, and the amount of accumulated dose were evaluated for therapeutic response. Clinical symptoms and radiographic images were utilized for the assessment of prognosis. Results Among the 86 patients, five were male, whereas 81 were female with mean age of 73.98 (range 45–97). Location of the lesion was in the mandible for 58 patients and maxilla in 25 patients. Three patients had both mandible and maxilla affected. This shows that the mandible is more prone to the formation of ONJ lesions compared to the maxilla. ONJ occurred in 38 cases after extraction, nine cases after implant surgery, six cases were denture use, and spontaneously in 33 cases. Seventy-six patients were taking other drugs aside from drugs indicated for osteoporosis. Most of these patients were diagnosed as osteoporosis, rheumatic arthritis, multiple myeloma, or had a history of cancer therapy. Higher weighted total accumulation doses were significantly associated with poorer prognosis ( P < 0.05). Conclusion Dose, duration, route, and relative potency of bisphosphonates are significantly associated with treatment prognosis of osteonecrosis of the jaw.

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“…Then, the weight of the dose deposited in the bone tissue was adjusted to the relative potency [28] (Table 2) of each bisphosphonate with the following formula [29]:…”

Section: Methodsmentioning

confidence: 99%

Pharmacoepidemiology and clinical characteristics of medication-related osteonecrosis of the jaw

Son

Kim

2019

Maxillofac Plast Reconstr Surg

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Management of systemic risk factors ahead of dental implant therapy: A beard well lathered is half shaved

Zhou

Liu

et al. 2021

Journal of Leukocyte Biology

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As the most successful therapy for missing teeth, dental implant has become increasingly prevalent around the world. A lot of papers have reported diverse local risk factors affecting the success and survival rate of dental implants, either for a short or a long period. However, there are also many types of systemic disorders or relatively administrated medicine that may jeopardize the security and success of dental implant treatment. Additionally, the coronavirus disease 2019 pandemic also poses a challenge to dental implant clinicians. Some of these risk factors are clinically common but to some extent unfamiliar to dentists, thus optimal measurements are often lacking when they occur in dental clinics. In this review, we analyze potential systemic risk factors that may affect the success rate of dental implants. Some of them may affect bone mineral density or enhance the likelihood of local infection, thus impeding osseointegration. Others may even systemically increase the risk of the surgery and threaten patients’ life. In order to help novices receive high‐risk patients who need to get dental implant treatment in a more reasonable way, we accordingly review recent research results and clinical experiments to discuss promising precautions, such as stopping drugs that impact bone mineral density or the operation, and addressing any perturbations on vital signs.

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Risk factors for bisphosphonate-associated osteonecrosis of the jaw in the prospective randomized trial of adjuvant bisphosphonates for early-stage breast cancer (SWOG 0307)

Kizub

Miao²,

Schubert

et al. 2020

Support Care Cancer

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Epidemiología, farmacología y caracterización clínica de la osteonecrosis de los maxilares. Un estudio retrospectivo de 70 casos

Cited by 8 publications

References 23 publications

Pharmacoepidemiology and clinical characteristics of medication-related osteonecrosis of the jaw

Pharmacoepidemiology and clinical characteristics of medication-related osteonecrosis of the jaw

Management of systemic risk factors ahead of dental implant therapy: A beard well lathered is half shaved

Risk factors for bisphosphonate-associated osteonecrosis of the jaw in the prospective randomized trial of adjuvant bisphosphonates for early-stage breast cancer (SWOG 0307)

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