Epidemiología del daño pulmonar agudo y síndrome de distrés respiratorio agudo

Riestra, Eva Manteiga; González, Oraida; Vivar, Fernando Frutos

doi:10.1016/s0210-5691(06)74496-5

Cited by 10 publications

(2 citation statements)

References 104 publications

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“…The ratio between arterial pressure of O 2 (PaO 2 ) and the FIO 2 concentration delivered by ventilator support distinguishes the two syndromes. For ALI, the PaO 2 /FIO 2 is ≤300 mm Hg and for ARDS, the PaO 2 /FIO 2 is ≤200 mm Hg [ 74 , 75 , 77 ].…”

Section: Clinical Presentation Of Hyperoxic Acute Lung Injurymentioning

confidence: 99%

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Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung

Mach

Thimmesch

Pierce

et al. 2011

Nursing Research and Practice

143

150

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Oxygen (O2) is life essential but as a drug has a maximum positive biological benefit and accompanying toxicity effects. Oxygen is therapeutic for treatment of hypoxemia and hypoxia associated with many pathological processes. Pathophysiological processes are associated with increased levels of hyperoxia-induced reactive O2 species (ROS) which may readily react with surrounding biological tissues, damaging lipids, proteins, and nucleic acids. Protective antioxidant defenses can become overwhelmed with ROS leading to oxidative stress. Activated alveolar capillary endothelium is characterized by increased adhesiveness causing accumulation of cell populations such as neutrophils, which are a source of ROS. Increased levels of ROS cause hyperpermeability, coagulopathy, and collagen deposition as well as other irreversible changes occurring within the alveolar space. In hyperoxia, multiple signaling pathways determine the pulmonary cellular response: apoptosis, necrosis, or repair. Understanding the effects of O2 administration is important to prevent inadvertent alveolar damage caused by hyperoxia in patients requiring supplemental oxygenation.

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Section: Clinical Presentation Of Hyperoxic Acute Lung Injurymentioning

confidence: 99%

“…Treatment includes mechanical ventilation, supportive care, and treatment of the underlying causes [ 16 ]. The mortality of ALI has improved over the past decade; however, it still ranges from 30% to 75% [ 75 , 77 , 82 , 83 ] and occurs in about 86 of 100,000 individuals per year [ 84 ].…”

Section: Clinical Presentation Of Hyperoxic Acute Lung Injurymentioning

confidence: 99%