Epidemic of Subclinical Infection with Cytomegalovirus in an Infant Home

Chiba, Shunzo; Ikeda, Shigeru; Chiba, Yasuo; Agatsuma, Yoshitaka; Ohsaki, Masami; Nakao, Tooru; Fukui, Sekt

doi:10.1620/tjem.106.387

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…(1973) on babies born to mothers whose cervical cultures were positive at late pregnancy indicated that the babies were virus negative at brith and started to excrete virus in urine between three to twelve weeks after birth . Thus recent studies indicate the importance of vertical transmission of CMV in infants living at home , though a greater risk of horizontal infection may be experienced in institutionalized infants (Chiba et al 1972). Frequencies of CMV recovery from infants in Japan are constant among the studies carried out in the different areas, such as 20% in Sendai (Numazaki et al 1970), 23% in Tokyo (Sakamoto 1974) and 22% in Sapporo as described above.…”

Section: Isolations From Infants With Various Diseasesmentioning

confidence: 99%

Primary Cytomegalovirus Infection and Liver Involvement in Early Infancy

Chiba

Hori

Kawamura

et al. 1975

Tohoku J. Exp. Med.

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Section: Isolations From Infants With Various Diseasesmentioning

confidence: 99%

Primary Cytomegalovirus Infection and Liver Involvement in Early Infancy

Chiba

Hori

Kawamura

et al. 1975

Tohoku J. Exp. Med.

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“…It is difficult to separate the effect of corticosteroids from other therapies or the activity of the underlying disease. In children without malignancies who were on corticosteroids, Chiba et al (1972) reported five out often had a fourfold or greaterrise in CMV antibody titer, compared with only one of 21 not so treated. Further analysis of this and other putative risk factors will only be possible when primary and secondary infections in patients with malignancies are meticulously distinguished in large prospective studies using serologic and virological methods.…”

Section: Risk Factors For Cytomegalovirus Lnfectionmentioning

confidence: 96%

Cytomegalovirus

1991

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All rights reserved 90-14345 CIP No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher Preface to the First EditionAlthough there are a number of excellent current reviews on one or another aspect of cytomegalovirus, the last comprehensive treatment of this subject was that of Krech et al. (197la). In view of the amazing advances in the virological, epidemiologic, and clinical knowledge of cytomegaloviruses, an up-to-date book is needed. Such a work should cover many areas of expertise and a voluminous technical literature. Each area might have been reviewed and analyzed by workers more expert than myself. However, I have embarked on the entire venture alone in order to attain unity and continuity in this book, characteristics that are not easily achieved in the more popular multiauthored works. I have tried to review the Iiterature and provide a critical summary for each area discussed. To do this, I provide as much of the primary data of the relevant works as needed and not just the qualitative conclusions. Inevitably, the flow of the narrative may be interrupted by dry facts and figures. However, such information is essential to make this a meaningful reference work. But for those not interested in such details, I have provided at what I hope are crucial points critiques and summaries.This book is not an exhaustive review of all the literature. This is probably no Ionger possible or even desirable. By selection, however, one runs the risk of having missed or ignored important papers. I am keenly aware of this, and I wish to apologize for such oversight, if that is possible.I visualize this work as being useful for physicians, scientists, and students interested in the biology of and infection by human cytomegalovirus. I feel that to understand these, the basic virology of this virus and related herpesviruses must be included. Topics that have not advanced a great deal and that are adequately described in available works, such as the anatomic pathology, have not been reviewed in detail. The emphasis has been placed on newer insights in the virology, immunology, serology, epidemiology, and especially clinical aspects of human cytomegalovirus. I wish tobring out the interactions of knowledge in these areas. Part II is a much shorter treatment of the nonhuman cytomegaloviruses, reviewed primarily from the point of view of their contribution to the understanding of the human virus. V vi Preface to the First Edition Finally, I wish to thank Drs. Charles R. Rinaldo, Jr., John A. Armstrong, and Donald N. Medearis for their critical review of the manuscript. Their suggestions were invaluable. Dr. John N. Dowling's thorough review of CMV infection in patients with malignancies was the basis of Section 13.4. I also acknowledge the indispensable and patient secretarial assistance of Ms.The remarkable medical events and advances in knowle...

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Enhanced Replication of Human Cytomegalovirus in Human Fibroblasts Treated with Dexamethasone

Tanaka

Ogura

Kamiya

et al. 1984

Journal of General Virology

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SUMMARYThe effect of glucocorticoid hormones on the replication of human cytomegalovirus (HCMV) was studied in human embryonic lung (HEL) cells. Treatment of cells with pharmacological concentrations of adrenal glucocorticoids such as dexamethasone enhanced HCMV replication; treatment with oestrogenic or androgenic hormones did not do so. In dexamethasone-treated HEL cells there was an approximately tenfold increase in virus yield, with the virus eclipse period shortened by 1 day compared to control cultures. Treatment of cells with the hormone also enhanced plaquing efficiency of the virus by approximately tenfold. As the synthesis of virus-specific immediate early proteins and antigens was notably enhanced together with an increase of HCMV DNA synthesis, it appeared that the early stages of the HCMV replication cycle might be under hormonal control. Moreover, the data presented suggest that the hormonal enhancement of HCMV replication involves specific receptor proteins and requires the synthesis of a specific cellular mRNA(s).

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Epidemic of Subclinical Infection with Cytomegalovirus in an Infant Home

Cited by 3 publications

References 6 publications

Primary Cytomegalovirus Infection and Liver Involvement in Early Infancy

Primary Cytomegalovirus Infection and Liver Involvement in Early Infancy

Cytomegalovirus

Enhanced Replication of Human Cytomegalovirus in Human Fibroblasts Treated with Dexamethasone

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