Primary Cytomegalovirus Infection and Liver Involvement in Early Infancy

Chiba, Shunzo; Hori, Shoko; Kawamura, N.; Nakao, Tooru

doi:10.1620/tjem.117.143

Cited by 13 publications

(2 citation statements)

References 19 publications

(16 reference statements)

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“…Neonatal and infantile hepatitis are closely related to CMV infection. Active CMV infection indicated by virus isolation and serum IgM antibody response has been described in infants with abnormal liver function tests or hepatomegaly such as three cases in the present study (Chiba et al 1975 ;Numazaki and Chiba 1993). It is quite hard to detect inclusion bodies or CMV antigen in the liver tissue from these patients by ordinary immunoperoxidase or immunofluorescence staining (Chang et al 1992).…”

Section: Resultssupporting

confidence: 54%

Effect of Glycyrrhizin in Children with Liver Dysfunction Associated with Cytomegalovirus Infection.

Numazaki

Umetsu

Chiba

1994

Tohoku J. Exp. Med.

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Section: Resultssupporting

confidence: 54%

Effect of Glycyrrhizin in Children with Liver Dysfunction Associated with Cytomegalovirus Infection.

Numazaki

Umetsu

Chiba

1994

Tohoku J. Exp. Med.

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“…The data suggests that HB virus transmitted from carrier mothers is responsible for some cases of hepatitis in early infancy in Japan. In the majority, however, other agents were supposed to be responsible for hepatitis of these categories (Chiba et al 1975). …”

Section: During This Period Abnormalmentioning

confidence: 99%

Clinical and edidemiological studies on hepatitis B in children.

Fujiwara

Chiba

Nakao

et al. 1977

Tohoku J. Exp. Med.

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Analysis of human cytomegalovirus-infected peripheral blood mononuclear cells from infants with liver dysfunction by flow cytometry and the polymerase chain reaction

Numazaki

Asanuma

Nagata

et al. 1994

Journal of Leukocyte Biology

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Perinatal human cytomegalovirus (HCMV) infection often involves the hepatobiliary tract, but infected individuals usually remain asymptomatic. We investigated the role of CD8+ lymphocytes in 13 infants with liver dysfunction associated with perinatal HCMV infection. In three patients more than 40% of CD8+ cells were positive for HCMV immediate early antigen (IEA) and late antigen (LA) by flow cytometry after selection of T lymphocytes subpopulations. In the other 10 infants, 20% to 30% of CD8+ cells were positive for HCMV IEA and LA. HCMV IE DNA was detected in CD8+ cells from one infant, in CD4+ cells from one infant, and in both CD4+ and CD8+ cells from three infants. HCMV infection of CD8+ cells may play an important role in the process of perinatal primary infection.

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Primary Cytomegalovirus Infection and Liver Involvement in Early Infancy

Cited by 13 publications

References 19 publications

Effect of Glycyrrhizin in Children with Liver Dysfunction Associated with Cytomegalovirus Infection.

Effect of Glycyrrhizin in Children with Liver Dysfunction Associated with Cytomegalovirus Infection.

Clinical and edidemiological studies on hepatitis B in children.

Analysis of human cytomegalovirus-infected peripheral blood mononuclear cells from infants with liver dysfunction by flow cytometry and the polymerase chain reaction

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