Epidemic arboviral diseases: priorities for research and public health

Wilder‐Smith, Annelies; Gubler, Duane J.; Weaver, Scott C.; Monath, Thomas P.; Heymann, David L.; Scott, Thomas W.

doi:10.1016/s1473-3099(16)30518-7

Cited by 442 publications

(354 citation statements)

References 42 publications

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“…Marina Baptista de Azevedo [1] , Márcia Sandre Coelho Coutinho [1] , Mônica Agostinho da Silva [1] , Denise Bastos Arduini [1] , Juliana Dias Vieira Lima [1] , Rosangela Monteiro [1] , Bárbara Nicácio Bahia Mendes [1] , Maria Cristina Ferreira Lemos [1] , Claudio Pompeiano Noronha [1] and Valéria Saraceni [1] [1]. Secretaria Municipal de Saúde do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.…”

Section: Short Communicationunclassified

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Neurologic manifestations in emerging arboviral diseases in Rio de Janeiro City, Brazil, 2015-2016

Azevedo

Coutinho

Silva

et al. 2018

Rev. Soc. Bras. Med. Trop.

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Introduction: Dengue has affected Rio de Janeiro City since the 1980s. The sequential Zika and chikungunya virus introductions during 2015 aggravated the health scenario, with 97,241 cases of arboviral diseases reported in 2015-2016, some with neurological disorders. Methods: Arbovirus-related neurologic cases were descriptively analyzed, including neurological syndromes and laboratory results. Results: In total, 112 cases with non-congenital neurologic manifestations (Guillain-Barré syndrome, 64.3%; meningoencephalitis, 24.1%; acute demyelinating encephalomyelitis, 8%) were arbovirus-related; 43.7% were laboratoryconfirmed, of which 57.1% were chikungunya-positive. Conclusions: Emerging arbovirus infections brought opportunities to study atypical, severe manifestations. Surveillance responses optimized case identification and better clinical approaches.

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Section: Short Communicationunclassified

“…Emerging mosquito-borne arboviral infections are widespread in the world, causing severe systemic and neurologic disorders that are virus-or immune-mediated 1 . Dengue has been endemic in Rio de Janeiro City (RJC) since the 1980s.…”

Section: Short Communicationmentioning

confidence: 99%

Neurologic manifestations in emerging arboviral diseases in Rio de Janeiro City, Brazil, 2015-2016

Azevedo

Coutinho

Silva

et al. 2018

Rev. Soc. Bras. Med. Trop.

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“…Most known flaviviruses are horizontally transmitted between hematophagous arthropods (i.e., mosquitoes and ticks) and vertebrate hosts; for example, dengue virus, yellow fever virus (YFV), Japanese encephalitis virus (JEV), West Nile virus (WNV), Zika virus (ZIKV) and tick-borne encephalitis virus (TBEV) [8,9,10]. Other flaviviruses have been isolated in nature exclusively from mosquitoes and sandflies and cannot replicate in vertebrate cell lines or suckling mice [11,12,13].…”

Section: Introductionmentioning

confidence: 99%

A Review of Flaviviruses that Have No Known Arthropod Vector

Blitvich

Firth

2017

Viruses

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Most viruses in the genus Flavivirus are horizontally transmitted between hematophagous arthropods and vertebrate hosts, but some are maintained in arthropod- or vertebrate-restricted transmission cycles. Flaviviruses maintained by vertebrate-only transmission are commonly referred to as no known vector (NKV) flaviviruses. Fourteen species and two subtypes of NKV flaviviruses are recognized by the International Committee on Taxonomy of Viruses (ICTV), and Tamana bat virus potentially belongs to this group. NKV flaviviruses have been isolated in nature almost exclusively from bats and rodents; exceptions are the two isolates of Dakar bat virus recovered from febrile humans and the recent isolations of Sokoluk virus from field-collected ticks, which raises questions as to whether it should remain classified as an NKV flavivirus. There is evidence to suggest that two other NKV flaviviruses, Entebbe bat virus and Yokose virus, may also infect arthropods in nature. The best characterized bat- and rodent-associated NKV flaviviruses are Rio Bravo and Modoc viruses, respectively, but both have received limited research attention compared to many of their arthropod-infecting counterparts. Herein, we provide a comprehensive review of NKV flaviviruses, placing a particular emphasis on their classification, host range, geographic distribution, replication kinetics, pathogenesis, transmissibility and molecular biology.

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“…Despite the increasing global burden of dengue both in terms of annual incidence and geographic distribution [1,2], dengue remains a neglected disease [3]. In 2010, the European Commission launched a Seventh Framework Programme call entitled ‘Comprehensive control of dengue under changing climatic conditions’.…”

Section: Introductionmentioning

confidence: 99%

Novel tools for the surveillance and control of dengue: findings by the DengueTools research consortium

Wilder‐Smith

Tissera

AbuBakar

et al. 2018

Global Health Action

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Background: Dengue fever persists as a major global disease burden, and may increase as a consequence of climate change. Along with other measures, research actions to improve diagnosis, surveillance, prevention, and predictive models are highly relevant. The European Commission funded the DengueTools consortium to lead a major initiative in these areas, and this review synthesises the outputs and findings of this work conducted from 2011 to 2016. Research areas: DengueTools organised its work into three research areas, namely [1] Early warning and surveillance systems; [2] Strategies to prevent dengue in children; and [3] Predictive models for the global spread of dengue.Research area 1 focused on case-studies undertaken in Sri Lanka, including developing laboratory-based sentinel surveillance, evaluating economic impact, identifying drivers of transmission intensity, evaluating outbreak prediction capacity and developing diagnostic capacity. Research area 2 addressed preventing dengue transmission in school children, with case-studies undertaken in Thailand. Insecticide-treated school uniforms represented an intriguing potential approach, with some encouraging results, but which were overshadowed by a lack of persistence of insecticide on the uniforms with repeated washing. Research area 3 evaluated potential global spread of dengue, particularly into dengue-naïve areas such as Europe. The role of international travel, changing boundaries of vectors, developing models of vectorial capacity under different climate change scenarios and strategies for vector control in outbreaks was all evaluated. Concluding remarks: DengueTools was able to make significant advances in methods for understanding and controlling dengue transmission in a range of settings. These will have implications for public health agendas to counteract dengue, including vaccination programmes. Outlook: Towards the end of the DengueTools project, Zika virus emerged as an unexpected epidemic in the central and southern America. Given the similarities between the dengue and Zika viruses, with vectors in common, some of the DengueTools thinking translated readily into the Zika situation.

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Epidemic arboviral diseases: priorities for research and public health

Cited by 442 publications

References 42 publications

Neurologic manifestations in emerging arboviral diseases in Rio de Janeiro City, Brazil, 2015-2016

Neurologic manifestations in emerging arboviral diseases in Rio de Janeiro City, Brazil, 2015-2016

A Review of Flaviviruses that Have No Known Arthropod Vector

Novel tools for the surveillance and control of dengue: findings by the DengueTools research consortium

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