(−)-Epicatechin protects from amebic liver abscess development in hamster

Velásquez-Torres, Maritza; Shibayama-Salas, Mineko; Pacheco‐Yépez, Judith; Silva-Olivares, Angélica; Sánchez-Monroy, Virginia; Marchat, Laurence A.; Rivera, Gildardo; Ramírez‐Moreno, Esther

doi:10.1016/j.exppara.2021.108103

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…), redox molecules (iNOS), and COX2 [ 47 – 49 ]. Previous studies have shown that Epi modulates the effect on IL-1 β , IL6, IL-10, TNF α , iNOS, COX2, and NF- κ B [ 50 , 51 ]. To explore the potential regulatory effects of Epi on the microglial activation response induced by LPS in this study, proinflammatory cytokine levels (IL-1 β , IL-6, and TNF α ) were measured using qRT-PCR and western blotting.…”

Section: Discussionmentioning

confidence: 99%

(−)-Epicatechin Reduces Neuroinflammation, Protects Mitochondria Function, and Prevents Cognitive Impairment in Sepsis-Associated Encephalopathy

Ling

Zou

et al. 2022

Oxidative Medicine and Cellular Longevity

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Sepsis-associated encephalopathy is a common neurological complication of sepsis. Despite advances in pathological and diagnostic investigations, its treatment remains a major challenge. In sepsis-associated encephalopathy, neuroinflammatory overactivation and mitochondrial damage are thought to contribute to cognitive and behavioral impairments. In this study, we found that administration of (−)-Epicatechin, a dietary flavonoid of the flavan-3-ol subgroup, improves memory deficits and behavior performance by ameliorating neuroinflammation, regulating mitochondria function, enhancing synaptic plasticity, and reducing neuronal loss in a mouse model of lipopolysaccharide-induced sepsis. We further show that the AMPK signaling pathway might be among the mechanisms involved in the beneficial memory effects. Our data demonstrated the potential of (−)-Epicatechin as a new drug candidate for the treatment of sepsis-associated cognitive impairment by targeting AMPK.

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Section: Discussionmentioning

confidence: 99%

(−)-Epicatechin Reduces Neuroinflammation, Protects Mitochondria Function, and Prevents Cognitive Impairment in Sepsis-Associated Encephalopathy

Ling

Zou

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Te EC dose (10 mg/100 g, I.P.) reduced the advancement of the liver abscess by modifying the infuence of the infammatory cytokines including interleukin-10, interleukin-1, TNF-α and aids in the removal of trophozoites to repair the liver [62].…”

Section: Epicatechinmentioning

confidence: 99%

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

Gajender

Mazumder

Sharma

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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The liver is a crucial organ that is involved in various kinds of metabolic activity and a very stable accessory gland for the digestive system. Long-term or persistent inflammation and oxidative stress due to any reasons have a substantial impact on the beginning and continuation of chronic diseases such as hepatocellular carcinoma, liver cirrhosis, liver fibrosis, and other hepatic conditions. There are many sources which can help the liver to be healthy and enhance its metabolic potential of the liver. Since the diet is rich origin of bioactive along with antioxidant chemicals including flavonoids and polyphenols, it can control different stages of inflammation and hepatic diseases. Numerous food sources, notably vegetables, nuts, fruits, cereals, beverages, and herbal medicinal plants, are rich in bioactive chemicals called flavonoids and their derivatives like Flavones, Anthocyanins, Iso-flavonoid, Flavanones, Flavanols, and Flavan-3-ols. Most recently occurred research on flavonoids has demonstrated that they can regulate hepatoprotective properties. This is because they are essential parts of pharmaceutical and nutraceutical products due to their hepatoprotective, antioxidative, and immune-modulating characteristics. However, the characteristics of their hepatoprotective impact remain unclear. The purpose of this comprehensive review is to survey the flavonoid structure and enriched sources for their hepatoprotective and antioxidant effects concerning liver toxicity or injury.

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In vitro and in vivo exploration of the anti-atopic dermatitis mechanism of action of Tibetan medicine Qi-Sai-Er-Sang-Dang-Song decoction

Liu

Tao

Zou

et al. 2023

Journal of Ethnopharmacology

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(−)-Epicatechin protects from amebic liver abscess development in hamster

Cited by 4 publications

References 24 publications

(−)-Epicatechin Reduces Neuroinflammation, Protects Mitochondria Function, and Prevents Cognitive Impairment in Sepsis-Associated Encephalopathy

(−)-Epicatechin Reduces Neuroinflammation, Protects Mitochondria Function, and Prevents Cognitive Impairment in Sepsis-Associated Encephalopathy

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

In vitro and in vivo exploration of the anti-atopic dermatitis mechanism of action of Tibetan medicine Qi-Sai-Er-Sang-Dang-Song decoction

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