In vitro and in vivo exploration of the anti-atopic dermatitis mechanism of action of Tibetan medicine Qi-Sai-Er-Sang-Dang-Song decoction

Liu, Jia; Tao, Yiwen; Zou, Xinyu; Liu, Qian; Meng, Xianli; Zhang, Yi; Su, Jinsong

doi:10.1016/j.jep.2023.116155

Cited by 4 publications

(3 citation statements)

References 53 publications

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“…Among them, the MAPK pathway, activated by EGF and EGFR signals, has been shown to control a wide range of physiological and pathological processes, including cell proliferation, gene expression, programmed cell death, and inflammation . Prior research has suggested that diminishing the expression of EGFR within the MAPK pathway can effectively alleviate the symptoms of AD in mice. , MAPKs, including ERK1/2 (MAPK3/1), JNK1/2/3, and p38 proteins (MAPK14), have been reported to be involved in AD. − IL-1β1, IL-6, and TNF-α act as proinflammatory cytokine genes, which can be activated by MAPK signaling pathways . Generally, an important cause of AD is the dysregulated Th1 and Th2 response .…”

Section: Discussionmentioning

confidence: 99%

“… 38 Prior research has suggested that diminishing the expression of EGFR within the MAPK pathway can effectively alleviate the symptoms of AD in mice. 39 , 40 MAPKs, including ERK1/2 (MAPK3/1), JNK1/2/3, and p38 proteins (MAPK14), have been reported to be involved in AD. 41 − 43 IL-1β1, IL-6, and TNF-α act as proinflammatory cytokine genes, which can be activated by MAPK signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

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Liangxue-Qushi-Zhiyang Decoction Ameliorates DNCB-Induced Atopic Dermatitis in Mice through the MAPK Signaling Pathway Based on Network Pharmacology

Zhang,

Niu

et al. 2024

ACS Omega

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The traditional prescription of Liangxue-Qushi-Zhiyang decoction (LQZ) has been demonstrated to be efficacious in treating atopic dermatitis (AD), a chronic inflammatory skin disorder marked by intense itching, redness, rashes, and skin thickening. Nevertheless, there has been an inadequate systematic exploration of the potential targets, biological processes, and pathways for AD treatment through LQZ. The study objective was to evaluate the efficacy and possible mechanism of LQZ in AD mice. In our study, we identified the primary compounds of LQZ, analyzed hub targets, and constructed a network. Subsequently, the predicted mechanisms of LQZ in AD were experimentally studied and validated in vivo, as determined by network pharmacological analysis. A total of 80 serum components of LQZ were identified through ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS), among which 49 compounds were absorbed into the bloodstream. Our results indicated that LQZ targets six putative key factors in the MAPK signaling pathway, which play essential roles in AD, namely, EGFR, p-MAPK1/3, p-MAPK14, IL-1β, IL-6, and TNF-α. We observed spleen coefficient, dermatitis scores, and ear thickness were all downregulated in 2,4dinitrochlorobenzene (DNCB)-induced mice after LQZ treatment. Histological analysis of the dorsal and ear skin further revealed that LQZ significantly decreased skin inflammation, epidermal thickness, and mast cell numbers compared to the DNCB group. Our study demonstrated the effectiveness of LQZ in reducing epidermal and dermal damage in a mouse model of AD. Furthermore, our findings suggest that downregulating the MAPK signaling pathway could be a potential therapeutic strategy for the treatment of AD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Liangxue-Qushi-Zhiyang Decoction Ameliorates DNCB-Induced Atopic Dermatitis in Mice through the MAPK Signaling Pathway Based on Network Pharmacology

Zhang,

Niu

et al. 2024

ACS Omega

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“…Some prescriptions containing “Shengdeng” have been clinically tested and modern pharmacological studies have demonstrated their significant anti-inflammatory effects. Several clinical studies have reported the effectiveness of Ershiwuwei ErCha Wan in treating rheumatoid arthritis, highlighting its high application value ( Huang et al, 2001 ; Zha et al, 2017 ; Liu et al, 2023 ). These medicinal properties have made “Shengdeng” a prominent ingredient in traditional Tibetan healing practices.…”

Section: Traditional Usesmentioning

confidence: 99%

A comprehensive review of Shengdeng in Tibetan medicine: textual research, herbal and botanical distribution, traditional uses, phytochemistry, and pharmacology

Ma,

Li,

Wang

et al. 2023

Front. Pharmacol.

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“Shengdeng”, a group of Tibetan medicines with diverse biological origins, has long been utilized in Tibet for the treatment of rheumatoid arthritis. It showcases remarkable efficacy in alleviating rheumatism, reducing swelling, and relieving pain. This study aimed to clarify the plant species used as “Shengdeng” and summarize their botanical distribution, traditional uses, phytochemistry, and pharmacology to promote its utilization and development. “Shengdeng” is derived from a remarkable collection of 14 plant species belonging to six distinct families. Extensive phytochemical investigations have led to the identification of 355 chemical constituents within “Shengdeng”. Pharmacological studies conducted on “Shengdeng” have revealed a wide range of beneficial properties, including antioxidant, anticancer, antimicrobial, antiviral, antiparasitic, anti-inflammatory, and anti-arthritic activities. Notably, flavonoids and triterpenoids emerge as the predominant groups among these constituents, contributing to the therapeutic potential and diverse applications of “Shengdeng”. The present review provides a concise summary of the recent advancements in textual research concerning the herbal and botanical distribution, traditional uses, phytochemistry, and pharmacological activities of “Shengdeng”. It is crucial to note that future research on “Shengdeng” should prioritize the analysis of its active ingredients and the establishment of rigorous quality standards. These aspects are essential for ensuring consistency, efficacy, and safety in its clinical application.

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J24335 exerts neuroprotective effects against 6-hydroxydopamine-induced lesions in PC12 cells and mice

Pan,

Shao,

Zhao

et al. 2024

European Journal of Pharmaceutical Sciences

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In vitro and in vivo exploration of the anti-atopic dermatitis mechanism of action of Tibetan medicine Qi-Sai-Er-Sang-Dang-Song decoction

Cited by 4 publications

References 53 publications

Liangxue-Qushi-Zhiyang Decoction Ameliorates DNCB-Induced Atopic Dermatitis in Mice through the MAPK Signaling Pathway Based on Network Pharmacology

Liangxue-Qushi-Zhiyang Decoction Ameliorates DNCB-Induced Atopic Dermatitis in Mice through the MAPK Signaling Pathway Based on Network Pharmacology

A comprehensive review of Shengdeng in Tibetan medicine: textual research, herbal and botanical distribution, traditional uses, phytochemistry, and pharmacology

J24335 exerts neuroprotective effects against 6-hydroxydopamine-induced lesions in PC12 cells and mice

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