Epicardial adipose tissue thickness in patients with ankylosing spondylitis

Reşorlu, Hatice; Akbal, Ayla; Reşorlu, Mustafa; Gökmen, Ferhat; Ateş, Can; Uysal, Fatma; Adam, Gürhan; Aylanç, Nilüfer; Arslan, Muhammet; İnceer, Beşir Şahin

doi:10.1007/s10067-014-2568-4

Cited by 30 publications

(21 citation statements)

References 18 publications

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“…Case-control studies allowing evaluation of carotid intima media thickness and endothelial dysfunction found a predisposition of FMF patients to atherosclerosis [4,5]. Mean platelet volume (MPV) and epicardial adipose tissue (EAT) thickness are novel parameters used in prediction of the risk of atherosclerosis [3,6-8]. Albeit contradictory results have been reported, there are some studies investigating the usefulness of MPV in assessment of atherosclerotic risk in cases with FMF [6,9,10].…”

Section: Introductionmentioning

confidence: 99%

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

et al. 2015

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BackgroundFamilial Mediterranean fever (FMF) is an inflammatory disease, which is suggested to be associated with increased risk of atherosclerosis. Epicardial adipose tissue (EAT) thickness and the mean platelet volume (MPV) are parameters used in prediction of atherosclerotic risk in various conditions. These parameters were evaluated in children with FMF and compared with healthy controls.MethodsForty-five patients with FMF and 54 age- and gender-matched healthy controls were assessed. Duration of symptoms, age at diagnosis, duration of delay in diagnosis, frequency and duration of FMF attacks, disease severity scores, response to colchicine therapy, MEditerraneanFeVer (MEFV) gene mutations, and MPV values were recorded. EAT thicknesses were measured by echocardiography.ResultsEpicardial adipose tissue thicknesses of the children with FMF were found to be significantly greater than that of controls (5.1 ± 1.4 vs. 4.5 ± 0.9 mm, p = 0.036). FMF patients had significantly higher MPV values compared with the controls (7.8 ± 1.1 vs. 7.3 ± 1.4 fl, p = 0.044). Age at diagnosis, duration of delay in diagnosis, and MPV values were found to be correlated with EAT thickness in the patient group (r = 0.49, p = 0.001 for the former parameters and r = 0.32, p = 0.04 for MPV).ConclusionEpicardial adipose tissue thickness and MPV values seem to be increased in children with FMF. These findings may indicate an increased risk of atherosclerosis in FMF patients.

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Section: Introductionmentioning

confidence: 99%

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

et al. 2015

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“…35 Nakanishi et al 36 used computed tomography to measure EFT levels and reported that patients with high levels had more coronary artery calcification. In studies by Cece et al 12 and Resorlu et al, 37 CIMT values in AS patients were found to be higher than those of the control group. In our study, AS patients had increased EFT thickness with high CIMT values.…”

Section: Discussionmentioning

confidence: 86%

Evaluation of Atrial Conduction Times, Epicardial Fat Thickness and Carotid Intima-Media Thickness in Patients With Ankylosing Spondylitis

et al. 2016

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Objectives: This study aims to determine the relationship between atrial electromechanical delay (EMD), carotid intima-media thickness (CIMT), and epicardial fat thickness (EFT) in ankylosing spondylitis (AS), which has a complicated inflammatory nature. Patients and methods:The study population included 42 consecutive patients with AS (28 males, 14 females; mean age 39.3±8.5 years; range 22 to 60 years) and 40 healthy subjects as controls (24 males, 16 females; mean age 37.2±8.7 years; range 22 to 60 years) (p>0.05). All patients underwent a standard tissue Doppler echocardiography to assess the left ventricular diastolic dysfunction, atrial EMD, CIMT, and EFT. All values were compared between the groups. Results: Interatrial (29.5±5.8 ms vs. 17.9±5.3 ms) left and right intraatrial EMD (18.2±4.6 ms and 11.7±3.5 ms vs. 11.9±3.2 ms and 7.1±3.2 ms, respectively) intervals were longer in AS patients than in healthy controls (all p<0.001). Left and right CIMT (0.50±0.11 mm and 0.44±0.06 mm vs. 0.51±0.11 mm and 0.43±0.04 mm, respectively) and EFT (0.73±0.15 cm and 0.63±0.07 cm) values were higher in AS patients than in healthy controls (all p<0.01). Conclusion: To our best knowledge, this is the first report evaluating the atrial EMD, CIMT, and EFT values together in AS patients. As indicators of cardiovascular involvement, all parameters were higher in AS patients.

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“…The most common non-skeletal finding is acute anterior uveitis or iridocyclitis [10].The more rarely seen cardiac and pulmonary involvement affects mortality. In addition to increased carotid intima media thickness and epicardial fat tissue, ascending aortitis, aortic valve insufficiency and transmission defects may also be observed [11,12]. Airway disease, interstitial anomalies and pleural thickening occur in pulmonary involvement [13].…”

Section: Discussionmentioning

confidence: 99%

Prospective evaluation of the renal morphology and vascular resistance in patients with ankylosing spondylitis.

et al. 2015

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Aims: To evaluate renal morphology, prevalence of urinary stone disease, renal perfusion and resistance to renal blood flow in patients with ankylosing spondylitis(AS). Material and methods: Thirty-eight patients diagnosed with AS and with normal basal renal functions, together with 38 healthy individuals matched in terms of age, sex, blood lipid profile and body mass index, were included. Total cholesterol, triglyceride, urea, creatinine and glucose levels were measured in both groups, as well as vitamin D, erythrocyte sedimentation rate (ESR) and C-reactive protein in the AS group. Renal dimensions, parenchymal echogenicity, presence of stone and renal resistive index (RRI) from the interlobular artery level were measured, and correlations with clinical and laboratory parameters were assessed. Results: Thirty-eight patients diagnosed with AS (age 42.4± 11.5, 24 male, 14 women) and a control group of 38 healthy individuals (age 41.7±10.8, 23 male, 15 female) were included in the study. Renal stone was present in 7 patients (18.4%) in the AS group and 4 subjects (10.5%) in the control group. There was no significant difference in prevalence of stone between the groups (p=0.516). RRI values were significantly higher in the patients with AS (0.63±0.06) compared with the control group (0.59±0.03, p=0.001). Significant correlations were determined between RRI and age, triglyceride level, body mass index and length of disease. Conclusions: Renal Doppler is an important examination in early diagnosis and monitoring of renal changes in AS patients since renal complications in AS develop in the chronic and follow a subclinical course.

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Epicardial adipose tissue thickness in patients with ankylosing spondylitis

Cited by 30 publications

References 18 publications

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

Evaluation of Atrial Conduction Times, Epicardial Fat Thickness and Carotid Intima-Media Thickness in Patients With Ankylosing Spondylitis

Prospective evaluation of the renal morphology and vascular resistance in patients with ankylosing spondylitis.

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