Prospective evaluation of the renal morphology and vascular resistance in patients with ankylosing spondylitis.

Abstract

Aims: To evaluate renal morphology, prevalence of urinary stone disease, renal perfusion and resistance to renal blood flow in patients with ankylosing spondylitis(AS). Material and methods: Thirty-eight patients diagnosed with AS and with normal basal renal functions, together with 38 healthy individuals matched in terms of age, sex, blood lipid profile and body mass index, were included. Total cholesterol, triglyceride, urea, creatinine and glucose levels were measured in both groups, as well as vitamin D, erythrocyte sedimentation rate (ESR) and C-reactive protein in the AS group. Renal dimensions, parenchymal echogenicity, presence of stone and renal resistive index (RRI) from the interlobular artery level were measured, and correlations with clinical and laboratory parameters were assessed. Results: Thirty-eight patients diagnosed with AS (age 42.4± 11.5, 24 male, 14 women) and a control group of 38 healthy individuals (age 41.7±10.8, 23 male, 15 female) were included in the study. Renal stone was present in 7 patients (18.4%) in the AS group and 4 subjects (10.5%) in the control group. There was no significant difference in prevalence of stone between the groups (p=0.516). RRI values were significantly higher in the patients with AS (0.63±0.06) compared with the control group (0.59±0.03, p=0.001). Significant correlations were determined between RRI and age, triglyceride level, body mass index and length of disease. Conclusions: Renal Doppler is an important examination in early diagnosis and monitoring of renal changes in AS patients since renal complications in AS develop in the chronic and follow a subclinical course.

Nephrolithiasis in Ankylosing Spondylitis and its Relation with Disease Assessment Scales

“…Although of unknown etiology, the formation of calculi requires a complex integration of numerous factors. Resorlu et al reported that 80%-90% of the renal calculi in patients with AS were calcium-based calculi supporting the possibility of problem primarily due to calcium metabolism [10].…”

“…An extra-articular involvement is common in inflammatory diseases. Although renal involvement has been shown in many studies on AS, the number of studies investigating the coexistence of renal calculi in AS is very limited [7][8][9][10][11][12][13].…”

“…Several studies showing an increased incidence of renal calculi in patients with AS have been published [7][8][9][10][11][12][13]. Jacobsen et al found the risk of nephrolithiasis in patients with AS to be more than twofold compared to the general population.…”

Sulfasalazine related nephrolithiasis in patients with rheumatoid arthritis and ankylosing spondylitis

“…They found the unadjusted hazard ratio of urolithiasis for AS compared to the healthy population of 2.4 (95% CI 2.1-2.9). 11 In Turkey in 2015, Resorlu et al 12 detected urolithiasis in 18.4% of AS patients and 10.4% of controls. Eliah et al 13 claimed that limited spinal mobility and pyelo-pelvic position in AS patients might be an underlying predisposing factor for urolithiasis.…”

Urolithiasis as an extraarticular manifestation of ankylosing spondylitis

“…In a 2015 study from Turkey, Resorlu et al compared 38 AS patients and 38 healthy controls in terms of frequency of kidney stone. They found urolithiasis was present among 18.4% of AS patients and 10.4% of controls [17].…”