Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway

Fu, Yang; Yuan, Peipei; Zheng, Yajuan; Gao, Liyuan; Wei, Yaxin; Chen, Yi; Li, Panying; Ruan, Yuan; Zheng, Xiaoke; Feng, Weisheng

doi:10.1016/j.biopha.2022.113061

Cited by 6 publications

(2 citation statements)

References 42 publications

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“…Many studies have concerned the role of natural products no DM and male reproductive functions (Tran et al, 2020;Swelum et al, 2021;Thikekar et al, 2021;Fu et al, 2022). Some researchers have used whole plants or part of plant extracts, such as Chlorophytum borivilianum (root), Amaranthus spinosus (stem), Danae racemosa (leaves), and Nigella sativa (seeds), while others have used just specific compounds such as phenols, flavonoids, and flavanones isolated from plants (Nna et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Shrimp Shell (Litopenaeus vannamei) Extract on Testicular Parameters of Streptozotocin-induced Diabetic Rats

Prasetyaningsih¹,

Adi²,

Wicaksono³

et al. 2023

WVJ

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Diabetes mellitus (DM) is a chronic metabolic disorder that has become a major health problem worldwide. Reproductive dysfunction is one of the main complications of DM, particularly in men. However, as is known, shrimp shell extract contains nutrients, such as astaxanthin, that affect reproductive traits. The present study aimed to evaluate the effect of shrimp shell extract on the volume, weight, and histological features of the testes of a DM rat model. Fifteen adult male rats were randomly divided into three groups. Group A (n = 5) was a healthy control group, group B (n = 5) was a DM control group, and group C (n = 5) was a DM group treated with shrimp shell extract. Rats in groups B and C were treated with streptozotocin to induce DM. Rats in group C were given shrimp shell extract at 25 mg/kg body weight for 30 consecutive days after DM induction. Testicles were collected and submitted to dimension, weight, and histological examinations. The testicle volume and weight of rats in group C were significantly higher and heavier, respectively, than rats in group B and did not differ from rats in group A. The seminiferous tubule diameter of rats in group C was significantly larger than rats in group B and did not differ from rats in group A. Rats in group B had a lower testicle volume and lighter testicle weight as well as a shorter seminiferous tubule diameter than rats in groups A and C. In conclusion, shrimp shell extract could improve male fertility parameters in a DM rat model. However, the mechanism of action needs to be studied further.

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Section: Introductionmentioning

confidence: 99%

The Effect of Shrimp Shell (Litopenaeus vannamei) Extract on Testicular Parameters of Streptozotocin-induced Diabetic Rats

Prasetyaningsih¹,

Adi²,

Wicaksono³

et al. 2023

WVJ

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“…It distributes in the arid and semiarid regions of Asia, America, Southeastern Europe, and Northern Africa and has been utilized for more than 5000 years [8]. During the past millennia, EH was extensively used for the treatment of allergies, colds, fever, asthma, coughs, edema, flu, headaches, and nasal congestion [9][10][11][12]. Various compounds such as alkaloids, polysaccharides, flavonoids, tannins, volatile oils, and organic acids had been identified in EH [13,14].…”

Section: Introductionmentioning

confidence: 99%

Comparative pharmacokinetic studies of Ephedra herba in common cold and nephrotic syndrome rat models

Cao

Zhou

Liu

et al. 2023

J of Separation Science

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Ephedra herba is a conventional Chinese medicine to treat cold, fever, asthma, edema, and lung diseases in the clinic. At present, most pharmacokinetic studies focus on the pharmacokinetic process of alkaloids in normal animals. However, the non-alkaloid components are also active. In addition, the pharmacokinetic studies under pathological state make more sense for clarifying the material basis of efficacy. In this study, a sensitive and rapid ultra-high-performance-tandem mass spectrometry method was developed and applied to determine nine bioactive components (ephedrine, pseudoephedrine, methylephedrine, (+)-catechin, epicatechin, vitexin, vicenin-2, cinnamic acid, and ferulic acid) in normal, common cold and nephrotic syndrome rats after the oral administration of Ephedra herba. Compared to the normal group, except for ferulic acid, the exposure levels of the other eight components were significantly increased and the plasma clearance clearly declined in common cold rats. Similarly, the exposure levels of seven components other than cinnamic acid and ferulic acid were also significantly augmented and the plasma clearance decreased significantly in nephrotic syndrome rats. In brief, the pathological conditions of the common cold and nephrotic syndrome could lead to alterations in the pharmacokinetics profiles of the nine components, which provide a reference for further exploration of the pharmacodynamics basis of Ephedra herba.

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Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome

Fu,

Yuan,

Zeng

et al. 2024

Heliyon

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Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway

Cited by 6 publications

References 42 publications

The Effect of Shrimp Shell (Litopenaeus vannamei) Extract on Testicular Parameters of Streptozotocin-induced Diabetic Rats

The Effect of Shrimp Shell (Litopenaeus vannamei) Extract on Testicular Parameters of Streptozotocin-induced Diabetic Rats

Comparative pharmacokinetic studies of Ephedra herba in common cold and nephrotic syndrome rat models

Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome

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