2015
DOI: 10.1101/lm.037101.114
|View full text |Cite
|
Sign up to set email alerts
|

Epac activation initiates associative odor preference memories in the rat pup

Abstract: Here we examine the role of the exchange protein directly activated by cAMP (Epac) in b-adrenergic-dependent associative odor preference learning in rat pups. Bulbar Epac agonist (8-pCPT-2-O-Me-cAMP, or 8-pCPT) infusions, paired with odor, initiated preference learning, which was selective for the paired odor. Interestingly, pairing odor with Epac activation produced both short-term (STM) and long-term (LTM) odor preference memories. Training using b-adrenergic-activation paired with odor recruited rapid and t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

1
15
0

Year Published

2016
2016
2022
2022

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 15 publications
(16 citation statements)
references
References 83 publications
1
15
0
Order By: Relevance
“…Thus, tubacin does not induce a generalized odor preference to normally aversive odors. We previously showed pups have the ability to show preference to the normally aversive orange odor if they are trained in the presence of orange odor (Grimes et al 2015). This, and the present findings, suggests tubacin-enhanced odor preference memory is specific to the paired odor.…”
Section: An Hdac 6 Inhibitor Extends Memory and Is Specific To The Cosupporting
confidence: 82%
“…Thus, tubacin does not induce a generalized odor preference to normally aversive odors. We previously showed pups have the ability to show preference to the normally aversive orange odor if they are trained in the presence of orange odor (Grimes et al 2015). This, and the present findings, suggests tubacin-enhanced odor preference memory is specific to the paired odor.…”
Section: An Hdac 6 Inhibitor Extends Memory and Is Specific To The Cosupporting
confidence: 82%
“…Stimulation of hippocampal slices with an EPAC agonist leads to increased LTP stability and activation of ERK (343,514). A similar formation of preferential long-term odor memory in rats was observed to be enhanced by the activation of an EPAC/ERK pathway (370). Another study also concluded that loss of EPAC2 could impair LTD in the hippocampus and illustrated a moderate reduction in learning behaviors in these animals (590).…”
Section: Behaviormentioning
confidence: 71%
“…Nonetheless, the currently sparse literature on Epac and memory processing supports the notion that Epac has key roles in memory dynamics. Epac activation can modulate associative odor memories in rat pups (Grimes et al 2015), and Epac signaling is critical for hippocampal memory retrieval (Ouyang et al 2008;Ostroveanu et al 2010). Conversely, Epac activation in the amygdala impeded cocaine-induced memory reconsolidation (Wan et al 2014).…”
Section: Discussionmentioning
confidence: 99%