Ep-1135 Radiation Therapy (+/− Chemotherapy) for Bladder Cancer in Very Elderly Patients

Concurrent chemotherapy is associated with improved survival in elderly patients with bladder cancer undergoing radiotherapy

“…The median reported age of patients in the reviewed studies was 78 years. The oldest definition of elderly used was age ≥78 years . In this study, the definition of elderly was pushed further back to age ≥80 years, primarily to identify a subset of patients for whom randomized data do not exist.…”

“…Turgeon and Souhami 20 conducted a review of the use of TMT for MIBC in elderly patients, in which they presented a table of outcomes and toxicity data from 8 publications and 4 conference abstracts, summing to a total of 496 elderly patients. [21][22][23][24][25][26][27][28][29][30][31][32] Although the definition of "elderly" is variable in the literature, Turgeon and Souhami reported the most common definition of elderly to be those aged 70 years, which was used in greater than one-half of the studies reviewed. The median reported age of patients in the reviewed studies was 78 years.…”

“…The oldest definition of elderly used was age 78 years. 31 In this study, the definition of elderly was pushed further back to age 80 years, primarily to identify a subset of patients for whom randomized data do not exist. In the elderly patient population in the current study, there remained a clear OS benefit for the use of CCRT for the treatment of MIBC.…”