Eosinophils in Gastrointestinal Disorders

Mehta, Pooja; Furuta, Glenn T.

doi:10.1016/j.iac.2015.04.003

Cited by 79 publications

(30 citation statements)

References 174 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Click et al [24] also showed that peripheral eosinophilia was associated with elevated levels of CRP, which could suggest an increased level of inflammation in IBD patients with peripheral eosinophilia. Other studies demonstrate that there are increased eosinophils in the histologic staining of mucosa collected from patients with active IBD [25, 28]. While further research is required to answer the question of exactly how IBD is associated with EoE, our results suggest that upper GI symptoms in patients with IBD should merit evaluation not only for upper GI CD, but also for esophageal eosinophilia.…”

Section: Discussionmentioning

confidence: 49%

Increased Prevalence of Esophageal Eosinophilia in Patients with Inflammatory Bowel Disease

et al. 2018

View full text Add to dashboard Cite

Background: The overlap between eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) has not been extensively examined. We aimed to assess the prevalence of esophageal eosinophilia in patients with IBD. Methods: We conducted a retrospective cohort study using diagnostic codes to identify adults with EoE and IBD between 2008 and 2016 at a tertiary care center. Electronic medical records were reviewed to extract clinical, endoscopic, and treatment data. Patients with esophageal eosinophilia and IBD were compared to EoE cases without IBD. Results: Of 621 EoE patients and 4,814 IBD patients identified, 35 had a code for both diseases and 12 were confirmed to have overlapping IBD and esophageal eosinophilia. The prevalence of esophageal eosinophilia in IBD was 12/4814 (0.25%), and the prevalence of confirmed EoE in IBD was 5/4,814 (0.10%). There were no substantial clinical, endoscopic, or histologic differences between EoE patients with and without IBD. IBD was diagnosed before esophageal eosinophilia 92% of the time, with an average time between diagnoses of 9.6 years. Of the IBD patients, 71% were started on biologic anti-tumor necrosis factor-α therapy an average of 7.6 years prior to developing esophageal eosinophilia. Conclusions: The prevalence of esophageal eosinophilia in IBD is 5 times higher than expected in the general population (0.25 vs. 0.05%) and EoE in IBD is 2 times higher than expected (0.10 vs. 0.05%). Upper gastrointestinal (GI) symptoms in patients with IBD should merit evaluation not only for upper GI Crohn’s disease, but also for esophageal eosinophilia.

show abstract

Section: Discussionmentioning

confidence: 49%

Increased Prevalence of Esophageal Eosinophilia in Patients with Inflammatory Bowel Disease

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The designation of “increased” eosinophils in this study is therefore inherently subjective and relies on the experience of the GI pathologist to distinguish levels of eosinophils that exceed the norm. Regardless of this evolving body of knowledge, the notion that eosinophils are found in increased numbers in the setting of inflammation is widely accepted, and recent studies have associated increased numbers of gastrointestinal eosinophils with a variety of specific inflammatory GI diseases (25, 26). Another limitation of this work, as with many retrospective studies, was our inability to provide adequate follow up data to definitively analyze outcomes of treatment modalities used in patients with eosinophilic inflammation.…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Eosinophilic Gastrointestinal Disease in Children With Intestinal Failure

Stamm¹,

Hait²,

Litman

et al. 2016

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

Objectives To describe the prevalence and clinical features of gastrointestinal eosinophilic inflammation among pediatric patients with intestinal failure (IF). Methods Medical records of all patients followed in our institution's intestinal failure program who underwent GI endoscopy over a 15 year period were reviewed and clinical, pathologic, nutrition and laboratory data collected. Results One hundred and five patients underwent 208 GI endoscopic procedures with biopsy. The overall prevalence of eosinophilic inflammation, defined as increased eosinophils in at least one tissue type on at least one endoscopy, was 39/105 (37%). The tissue-specific prevalence of eosinophilic inflammation ranged widely, with the colon/rectosigmoid being the most common (18/68, 26%), followed by the esophagus (17/83, 20%), ileum (9/54, 17%), duodenum (4/83, 5%), and stomach (3/83, 4%). Higher peripheral eosinophil count and hematochezia were associated with eosinophilic inflammation in the colon (p=0.002 and 0.0004, respectively). The use of a strict elemental diet for 3 months prior to endoscopy was not associated with a decreased frequency of eosinophilic inflammation in any tissue. Conclusions Eosinophilic inflammation is a common histopathologic finding in IF patients. Colonic eosinophilic inflammation is associated with clinical symptoms of GI blood loss, and peripheral eosinophilia, and was not abrogated by a strict elemental diet.

show abstract

“…Abnormal accumulation of eosinophils in the intestine in the absence of other underlying causes (eg, parasitic infections) is a characteristic feature of EGID, including IBD 4, 19. Staining of duodenal biopsy specimens with H&E for histopathological evaluation is routinely performed during diagnosis of IBD in dogs 13, 14.…”

Section: Discussionmentioning

confidence: 99%

Assessment of eosinophils in gastrointestinal inflammatory disease of dogs

Baştan

Seelig

Day

et al. 2018

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundAccurate identification of eosinophils in the gastrointestinal (GI) tract of dogs with eosinophilic GI disease (EGID) by histological evaluation is challenging. The currently used hematoxylin and eosin (H&E) staining method detects intact eosinophils but does not detect degranulated eosinophils, thus potentially underrepresenting the number of infiltrating eosinophils.ObjectiveTo develop a more sensitive method for identifying and quantifying both intact and degranulated eosinophils to diagnose EGID more accurately.MethodsEndoscopically obtained paraffin‐embedded intestinal biopsy specimens from dogs with GI signs were examined. The study groups were dogs with eosinophilic enteritis (EE), lymphoplasmacytic and mixed enteritis, and control dogs with GI signs but no histologic changes on tissue sections. Consecutive sections were immunolabeled with monoclonal antibodies (mAbs) against the eosinophil granule protein eosinophil peroxidase (Epx) and stained by H&E, respectively. The number of eosinophils was manually quantified and classified as intact or degranulated.ResultsThe number of intact eosinophils detected in Epx mAb‐labeled duodenal sections was significantly higher compared with that in H&E‐stained sections, with a similar relationship noted in the colon and stomach. The Epx mAb allowed the unique assessment of eosinophil degranulation. The number of intact and degranulated eosinophils was significantly higher in duodenal lamina propria of the EE and mixed group compared to the control group.ConclusionImmunohistochemical detection of Epx provides a more precise method to detect GI tract eosinophils compared to H&E staining and could be used as an alternative and reliable diagnostic tool for assessment of biopsy tissues from dogs with EGID.

show abstract

Eosinophils in Gastrointestinal Disorders

Cited by 79 publications

References 174 publications

Increased Prevalence of Esophageal Eosinophilia in Patients with Inflammatory Bowel Disease

Increased Prevalence of Esophageal Eosinophilia in Patients with Inflammatory Bowel Disease

High Prevalence of Eosinophilic Gastrointestinal Disease in Children With Intestinal Failure

Assessment of eosinophils in gastrointestinal inflammatory disease of dogs

Contact Info

Product

Resources

About