Eosinophilic Ulcer of the Tongue

Shapiro, Lucille; Juhlin, Einer A.

doi:10.1159/000252558

Cited by 34 publications

(10 citation statements)

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“…In infants, this lesion has been called Riga–Fede’s disease, sublingual ulcer, sublingual granuloma and reparative lesion of the tongue (3). Moreover, similar clinical characteristics and identical histological features have been reported as ulcerated granuloma eosinophilicum diutinum (4), traumatic granuloma of tongue (5), eosinophilic granuloma of tongue (6), eosinophilic ulcer of tongue (7), traumatic eosinophilic granuloma (8) and ulcerative eosinophilic granuloma of the tongue (9).…”

mentioning

confidence: 59%

Oral traumatic granuloma: report of a case and review of literature

Joseph

BairavaSundaram

2010

Dental Traumatology

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– Traumatic granuloma is an uncommon condition considered to be a benign, reactive lesion that usually affects the tongue. The exact pathogenesis implicated in the development of this lesion is not clear. However, trauma has been found to be a contributing factor in a majority of the cases. Clinically, it often presents as an ulceration or an indurated submucosal mass. Microscopically, it is characterized by a diffuse polymorphic cell infiltrate composed predominantly of eosinophils extending deep into the submucosa causing degeneration of the underlying muscle. Recognition of the lesion is important because it often mimics oral squamous cell carcinoma. But traumatic granuloma is self‐limiting and tends to resolve spontaneously. This paper describes a case of traumatic granuloma on the dorsal surface of tongue in a 62‐year‐old woman. The clinical aspects, pathogenesis and histopathology of this uncommon lesion are discussed with an emphasis on its benign, self‐limiting nature.

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confidence: 59%

Oral traumatic granuloma: report of a case and review of literature

Joseph

BairavaSundaram

2010

Dental Traumatology

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“…Nach der Häufigkeit ist die Zunge am stärksten betroffen, gefolgt von der bukkalen Mukosa und den Lippen [6,8,15,20,24,25]. Meist besteht nur eine wenig schmerzhafte Einzelläsion.…”

Section: Synonymenvielfalt Und Ungeklärte Pathogeneseunclassified

“…Ferner sollte ein luetischer Primäraffekt ausgeschlossen werden [6,22]. Bei Läsionen an der Schleimhaut von Kindern kommt differenzialdiagnostisch eine Langerhans-Zell-Histiozytose in Betracht [17,24].Auch eine Tuberkulose muss als Differenzialdiagnose erwogen werden.Weiterhin ist an die schankriforme Pyodermie zu denken, insbesondere bei der untypischen Lokalisation des eosinophilen Ulkus am Mundwinkel, aber auch bei der Läsion an der Unterlippe mit Nachweis von Staphylococcus aureus. Das klinische Erscheinungsbild beider Krankheiten ist sehr ähnlich, auch der Verlauf [2,10,12,14].…”

Section: Differenzialdiagnostikunclassified

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Das eosinophile Ulkus der Mundschleimhaut Differenzialdiagnose zu anderen oralen Ulzerationen

2002

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Eosinophilic ulcers of the oral mucosa represent a rare, self-limiting disease of unknown origin. Single lesions occur typically in the oral cavity or on the lower lip. Characteristically, they have a short history and resolve spontaneously. Diagnosis is verified by the histologic feature of a deep polymorphic inflammatory infiltrate with numerous eosinophils. The clinical aspect shows a usually nontender ulcer with a white or yellowish base and elevated indurated borders or a tumor with central ulceration. Lymphadenopathy is not found. Differential diagnoses include malignant tumors and the primary stage of syphilis. We present three cases recently diagnosed in our department to show the characteristics and the different appearances of the disease. A 74-year-old woman presented with an ulcer at the base of the tongue, a 59-year-old man had one on the lower lip, and in a 48-year-old man the lesion was atypically located at the edge of the mouth. Here we demonstrate the importance of knowledge of the disease, its course, and the characteristic histology to avoid troublesome diagnostic and therapeutic procedures.

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“…The first case describing an analogous lesion in adults was published in 1956 by Popoff [10]. A few years later, Shapiro and Juhlin described this lesion as a separate independent entity [11]. Different terms have been used in the literature to describe this phenomenon ever since.…”

Section: Introductionmentioning

confidence: 99%

Traumatic ulcerative granuloma with stromal eosinophilia — clinical case report, literature review, and differential diagnosis

et al. 2019

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BackgroundTraumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare self-limiting condition of the oral mucosa. The lesion manifests as an isolated ulcer that can be either asymptomatic or associated with mild to severe pain, and in most cases, it affects the tongue. TUGSE lesions may mimic malignancy such as squamous cell carcinoma, CD30 positive lymphoproliferative disorder, or infectious diseases such as primary syphilis, tuberculosis, or Epstein-Barr virus mucocutaneous ulcer. Histologically dominating cells are lymphocytes, histiocytes, and eosinophils.Case presentationWe describe a TUGSE case of a patient with a solitary ulcer on the lower left retromolar buccal plane. Upon presentation, the patient reported a swelling on the buccal mucosa of the left lower jaw since 1 year with rapid growth over the last days and mild pain while chewing. The diameter of the intraoral lesion on the lower left retromolar buccal plane was approximately 4 × 3 cm; the lesion presented as indurated base with a central superficial ulceration of 2 × 1 cm, indicative for a malignant process. Histologically, the ulceration showed an expanding, infiltrative, and vaguely granulomatous morphology, involving the superficial mucosa and the fatty tissue, and extended between the deep striated muscle fibers. The lesion was rich in lymphocytes, histiocytes, and eosionophils intermingled with activated T-blasts without phenotypic abnormalities. TUGSE was then diagnosed based on the phenotype (especially the lacking expression of CD30, the retained T-cell phenotype, and the absence of Epstein-Barr virus), the clinical presentation, and the morphology. Twenty-six months after diagnosis, no recurrence of the ulceration was seen.ConclusionsAs TUGSE may mimic malignancy or infectious diseases, biopsy is mandatory and should be combined with thorough clinical examination. A screening for infectious diseases (mainly syphilis, Epstein-Barr virus, and HIV infections) must be performed routinely. In most cases, the lesions resolve spontaneously, obviating the need of further actions other than clinical follow-up. The pathogenesis of TUGSE lesions is still under debate, although local traumatic events and a locotypic immune response have been suggested to be major contributing factors.

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Eosinophilic Ulcer of the Tongue

Cited by 34 publications

References 1 publication

Oral traumatic granuloma: report of a case and review of literature

Oral traumatic granuloma: report of a case and review of literature

Das eosinophile Ulkus der Mundschleimhaut Differenzialdiagnose zu anderen oralen Ulzerationen

Traumatic ulcerative granuloma with stromal eosinophilia — clinical case report, literature review, and differential diagnosis

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