Eosinophilic Inflammation in the Middle Ear Induces Deterioration of Bone-Conduction Hearing Level in Patients With Eosinophilic Otitis Media

Iino, Yukiko; Usubuchi, Hajime; Kodama, Kozue; Kanazawa, Hiromi; Takizawa, Kenji; Kanazawa, Takemichi; Ohta, Yasushi

doi:10.1097/mao.0b013e3181bc3781

Cited by 36 publications

(23 citation statements)

References 12 publications

(14 reference statements)

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“…High-tone loss was more frequently encountered and more severe in EOM patients than in age-matched patients with chronic otitis media (20). Our previous study also showed that the concentration of IgE in MEE was significantly and positively correlated with the BCHLs at 2 and 4 kHz and that a high concentration of IgE in the MEE as well as a high serum IgE level were significant risk factors for BCHL deterioration in EOM patients (7). Therefore, anti-IgE therapy can prevent BCHL deterioration.…”

Section: Anti-ige Therapy Was First Included Inmentioning

confidence: 83%

See 1 more Smart Citation

Clinical Efficacy of Anti-IgE Therapy for Eosinophilic Otitis Media

Iino

Hara²,

Hasegawa³

et al. 2012

Otology &Amp; Neurotology

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Section: Anti-ige Therapy Was First Included Inmentioning

confidence: 83%

“…In addition, many IgE-immunopositive cells are found in the middle ear mucosa (4). In the middle ear effusion (MEE), the IgE levels are significantly higher in EOM patients than in control patients with common otitis media with effusion (7). The presence of high levels of IgE may exacerbate eosinophilic inflammation in the middle ear.…”

mentioning

confidence: 98%

Clinical Efficacy of Anti-IgE Therapy for Eosinophilic Otitis Media

Iino

Hara²,

Hasegawa³

et al. 2012

Otology &Amp; Neurotology

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“…To identify EOM in cases of NP could entail watching patients more closely. Indeed, an increased incidence of progressive and/or sudden sensorineural hearing loss had been described in cases of EOM [24], with bacterial infection and inflammatory mediators released in the middle ear contributing to inner ear damage [25]. This bone conduction hearing loss sometimes can lead to profound deafness.…”

Section: Otitis Media With Effusion In Nasal Polyposis: How To Manage?mentioning

confidence: 98%

Is There an Association Between Otitis Media and Nasal Polyposis?

Parietti‐Winkler¹,

Jankowski²

2011

Curr Allergy Asthma Rep

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The association between otitis media with effusion (OME) and nasal polyposis (NP) is poorly described. However, two different approaches to this problem seem to come from the few studies concerning both otitis media and NP in the literature. One study was based on the assessment of a population of patients presenting with NP, with the authors interested in patients among the studied population who complained of ear-related symptoms and developed OME (rhinologic approach). Other studies were based on the assessment of a population of patients developing a particular OME, with the authors interested in characterizing this condition they named eosinophilic otitis media (otologic approach). The article reviews currents concepts in the relationship between OME and NP. It appears that regardless of the approach to the problem of interest (rhinologic or otologic approach), OME and NP seem to be closely related. Moreover, some striking similarities can be noted between the different entities described in the different studies reviewed, and all authors seem to agree that the middle ear has a central role in the concept of united airways inflammatory disease. Otologists and rhinologists should work together on a single approach that allows for better management of inflammatory disease leading to the formation of polyps, development of concurrent asthma, appearance of aspirin intolerance, and finally involvement of the middle ear.

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“…High-tone hearing loss, in particular, is more frequent and more severe in EOM patients than in COM patients [7], with 47% of EOM patients showing deterioration in BCHL, and 6% developing bilateral profound hearing loss according to the clinical survey of EOM in Japan [4]. The cause of deterioration in BCHL in cases of EOM remains unclear, but significantly higher concentrations of eosinophil cationic protein (ECP) and IgE have been detected in the middle ear effusion of EOM patients than in that of control patients [8]. Further, numerous eosinophil infiltrations were in the scala tympani, as well as severe morphological damage to the cochlea, the organ of Corti and the stria vascularis was observed in the prolonged topical stimulation animal model and is thought to be the cause of the deterioration in BCHL [9].…”

Section: Discussionmentioning

confidence: 99%

Cochlear Implantation in Patients with Eosinophilic Otitis Media

Takahashi¹,

Arai²,

Sakuma³

et al. 2015

IJOHNS

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It is known that cochlear implantation for deaf patients with eosinophilic otitis media (EOM) is safe and can provide good speech perception. However, the best timing of implant surgery in patients with EOM is not yet known. The aim of this case report is to suggest the appropriate timing of the surgery in EOM patients with deaf. Cochlear implantation was indicated in two patients with EOM. One underwent cochlear implantation in the absence of any ear discharge. In the other case, implant surgery was delayed for three years due to persistent ear discharge. No complications related to implant device or skin flap were observed in either case. The speech recognition score after implantation was good in the first case and poor in the second case. Perioperative complications were manageable even in the patient with persistent ear discharge. However, the delay in implant surgery due to the persistent ear discharge resulted in a poor speech recognition score. Early implantation should be considered even in EOM patients with ear discharge, although the presence of active middle ear inflammation is regarded as one of the contraindications for implantation according to the current Japanese guidelines.

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Eosinophilic Inflammation in the Middle Ear Induces Deterioration of Bone-Conduction Hearing Level in Patients With Eosinophilic Otitis Media

Cited by 36 publications

References 12 publications

Clinical Efficacy of Anti-IgE Therapy for Eosinophilic Otitis Media

Clinical Efficacy of Anti-IgE Therapy for Eosinophilic Otitis Media

Is There an Association Between Otitis Media and Nasal Polyposis?

Cochlear Implantation in Patients with Eosinophilic Otitis Media

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