Clinical Efficacy of Anti-IgE Therapy for Eosinophilic Otitis Media

Iino, Yukiko; Hara, Mariko; Hasegawa, Masayo; Matsuzawa, Shingo; Shinnabe, Akihiro; Kanazawa, Hiromi; Yoshida, Naohiro

doi:10.1097/mao.0b013e318263d5b8

Cited by 51 publications

(24 citation statements)

References 17 publications

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“…The variables were used as independent variables in multiple linear regression analysis, which was performed to identify risk Table 1 Scoring system used to evaluate the severity of eosinophilic otitis media (Iino et al [6]). …”

Section: Discussionmentioning

confidence: 99%

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Risk factors associated with severity of eosinophilic otitis media

et al. 2014

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Section: Discussionmentioning

confidence: 99%

“…These items were scored on a scale from 0 to 2 (Table 1 [6]). Patients were evaluated every 3 months.…”

Section: Evaluation Of Severity Of Eommentioning

confidence: 99%

Risk factors associated with severity of eosinophilic otitis media

et al. 2014

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“…Thus, the beneficial effect of omalizumab action was observed in bronchopulmonary aspergillosis [60,61], Churg-Strauss syndrome [62,63], eosinophilic pneumonia [64], Kimura disease [65], eosinophilic otitis media [66], and eosinophilic gastrointestinal syndromes [67].…”

Section: Efficacy Of Omalizumab In Syndromes With Eosinophiliamentioning

confidence: 99%

The Effect of Omalizumab on Eosinophilic Inflammation of the Respiratory Tract in Patients with Allergic Asthma

Kupryś‐Lipińska¹,

Molińska²,

Kuna³

2016

Advances in Respiratory Medicine

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Bronchial asthma is characterised by high levels of immunoglobulin E (IgE) and overproduction of pro-inflammatory cytokines, including interleukins IL-4, IL-13 and IL-5 needed for, amongst other things, the production of IgE and the differentiation, maturation, migration and survival of eosinophils. Eosinophils are one of the most important cells in allergic inflammation. Their presence in tissue is linked to the persistence of inflammatory infiltrate, tissue damage and remodelling. Although these cells are very sensitive to corticosteroids, some asthmatic patients do not respond to high doses of these drugs, even when administered systemically. Transbronchial biopsies and bronchoalveolar lavage performed in patients with steroid-resistant asthma have demonstrated higher levels of eosinophils and Th2-type cytokines (IL-4 and IL-5) compared to steroid-sensitive patients. Clinical studies have confirmed that the very effective treatment in these cases is therapy with omalizumab -an anti-IgE monoclonal antibody. The paper discusses the efficacy of omalizumab in reducing eosinophil number in peripheral blood and in the airways of asthmatic patients based on basic, clinical, observational studies and case reports. The significance of omalizumab therapy in asthma control and mechanisms that regulate the effects of omalizumab on eosinophils are evaluated.

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“…EOM has frequently been associated with asthma and shown a good response to omalizumab93 together with an interesting reduction in eosinophil's proteins in middle ear fluids 94. The efficacy of association of omalizumab and immunotherapy in allergic patients was also demonstrated in another study,95 in which the addition of anti-IgE allowed for escalation of therapeutic allergen doses.…”

Section: Future Perspectives (Off-label Uses)mentioning

confidence: 92%

Personalized Medicine in Allergy

Ferrando

Bagnasco

Varricchi

et al. 2017

Allergy Asthma Immunol Res

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Allergic disease is among the most common pathologies worldwide and its prevalence has constantly increased up to the present days, even if according to the most recent data it seems to be slightly slowing down. Allergic disease has not only a high rate of misdiagnosis and therapeutic inefficacy, but represents an enormous, resource-absorbing black hole in respiratory and general medicine. The aim of this paper is to summarize principal therapeutic innovations in atopic disease management befallen in the recent years in terms of personalized/precision medicine.

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Clinical Efficacy of Anti-IgE Therapy for Eosinophilic Otitis Media

Cited by 51 publications

References 17 publications

Risk factors associated with severity of eosinophilic otitis media

Risk factors associated with severity of eosinophilic otitis media

The Effect of Omalizumab on Eosinophilic Inflammation of the Respiratory Tract in Patients with Allergic Asthma

Personalized Medicine in Allergy

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