Risk factors associated with severity of eosinophilic otitis media

Kanazawa, Hiromi; Yoshida, Naohiro; Yamamoto, Hiroki; Hara, Mariko; Hasegawa, Masayo; Matsuzawa, Shingo; Shinnabe, Akihiro; Iino, Yukiko

doi:10.1016/j.anl.2014.08.003

Cited by 20 publications

(11 citation statements)

References 23 publications

(34 reference statements)

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“…The purpose of this study was not to focus on the clinical definition or pathophysiology of EOM. However, it does appear that our patient group is very similar to many previously published reports . Our study agrees with the clinical demographics and presentation of EOM patients in that patients are often diagnosed with adult onset asthma and nasal polyposis long before EOM onset in their 4th and 5th decade.…”

Section: Discussionsupporting

confidence: 92%

“…However, it does appear that our patient group is very similar to many previously published reports. 1,2,4,5,16 Our study agrees with the clinical demographics and presentation of EOM patients in that patients are often diagnosed with adult onset asthma and nasal polyposis long before EOM onset in their 4th and 5th decade. Our study also agrees that EOM typically presents as bilateral ear disease that is treatment refractory to typical allergy, antibiotic, and chronic suppurative otitis media surgical treatments.…”

Section: Discussionsupporting

confidence: 86%

“…The examination was classified by the condition of the middle ear mucosa as previously reported with a minor modification. Grade 1 is normal (unthickened) middle ear mucosa, grade 2 is thickened mucosa within the middle ear, and grade 3 is thickened or edematous mucosa with predominant granulation tissue in the middle ear with or without extension to the external auditory canal (also known as “granulation type”) . Grade 3 was modified because we did not see a difference in presentation or treatment response if the granulation and polyp disease stopped at the tympanic membrane or extended to involve the external auditory canal.…”

Section: Methodsmentioning

confidence: 99%

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Treatment of eosinophilic otitis media with pegylated interferon‐α 2a and 2b

et al. 2016

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 86%

Section: Methodsmentioning

confidence: 99%

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Treatment of eosinophilic otitis media with pegylated interferon‐α 2a and 2b

et al. 2016

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“…13 This and subsequent Japanese studies found that this condition was often related to asthma and nasal polyposis. [13][14][15][16] EOM is also known to be difficult to treat. 16 Moreover, it can lead to a deterioration of bone-conduction hearing levels.…”

Section: Discussionmentioning

confidence: 99%

Chronic Otitis Media with Effusion in Chronic Sinusitis with Polyps

et al. 2018

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The relationship between otitis media with effusion (OME) and chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unclear. We conducted a cross-sectional study of 80 consecutively presenting patients—42 males and 38 females, aged 15 to 76 years (median: 48)—who were diagnosed with CRSwNP. Our aim was to ascertain the prevalence of OME in CRSwNP patients, to determine whether the severity of CRSwNP affected OME, and to identify risk factors for OME in CRSwNP patients. The severity of CRSwNP was assessed on the basis of nasal symptoms, endoscopic nasal examinations, and Lund-Mackay staging scores. In addition to demographic data, we obtained information on each patient's history of otitis, otoscopic findings, and the results of pure-tone audiometry and tympanometry. We then compared the data between CRSwNP patients with OME (n = 20) and those without (n = 60). In the OME group, a conductive hearing loss was present in 16 patients (80.0%); all patients in the control group had normal hearing. With regard to symptoms, only rhinorrhea appeared to be more common in patients with OME than in those without, although the difference was not statistically significant. We found no significant difference in nasal polyposis grades between the two groups. Also, we found no correlations between the risk of OME and previous surgical treatment, asthma, allergy, aspirin intolerance, aspirin and/or NSAID intolerance, aspirin and/or sulfite intolerance, and aspirin-exacerbated respiratory disease. Based on our findings, we conclude that OME occurs frequently during the evolution of CRSwNP, even when the nasal disease is well controlled. This finding suggests the possible presence, in OME and/or CRSwNP, of a global inflammatory process that involves the epithelium in both the middle ear and upper airway.

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“…Edematous mucosa causing granulation tissue in the mesotympanum is considered a characteristic of EOM. 5 Esu et al has classified EOM into 3 grades based on the middle ear mucosal thickness where grade 1 (G1) is normal middle ear mucosa; grade 2 (G2), thickened mucosa localized to the middle ear; and grade 3 (G3), edematous mucosa with predominant granulation tissue extending to the external auditory canal. 6 The granulations are recalcitrant to conventional treatment for COM but show exceptional results with steroid therapy.…”

mentioning

confidence: 99%