Eosinophilic granuloma: resolution of maxillofacial bony lesions following minimal intervention Report of three cases and a review of the literature

Key, Steven; O'Brien, C J; Silvester, K.C.; Crean, St John

doi:10.1016/j.jcms.2004.01.004

Cited by 49 publications

(28 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This disease occurs in dogs as a collagen tissue degeneration [1,[3][4][5]. In humans, some reports have proposed several mechanisms of pathogenesis as vasculitis, microangiopathies, fibromatosis, phagocytic dysfunction, and cell mediated immune-response dysfunction [6].…”

Section: Introductionmentioning

confidence: 99%

Canine Oral Eosinophilic Granuloma Treated with Electrochemotherapy

Tellado

Michinski

Olaiz

et al. 2014

Case Reports in Veterinary Medicine

View full text Add to dashboard Cite

A case of a canine oral eosinophilic granuloma in a 14-year-old female crossbred is described. The dog was presented with a history of ptyalism, halitosis, local pain, decreased appetite, and blood staining noted on food and water bowls. Clinical, hematologic, and biochemical examinations, abdominal ultrasonography, and 3-view chest radiographs were performed, and no metastases were found. Histopathologic examination of two 6 mm punch biopsies from the oral lesion revealed the presence of eosinophilic granulomatous lesions in the submucosa. After treatment with corticosteroids and wide spectrum antibiotics no significant changes in clinical signs and lesion size were observed. Electrochemotherapy (ECT), a novel tumor treatment routinely used for cutaneous and subcutaneous tumors in human patients in the European Union since 2006, was used to treat the eosinophilic granuloma. The procedure was performed under general anesthesia, followed by intravenous administration of bleomycin. Six weeks after treatment a complete response with disappearance of the mass and improvement of clinical signs were observed.

show abstract

Section: Introductionmentioning

confidence: 99%

Canine Oral Eosinophilic Granuloma Treated with Electrochemotherapy

Tellado

Michinski

Olaiz

et al. 2014

Case Reports in Veterinary Medicine

View full text Add to dashboard Cite

show abstract

“…Routine diagnosis is usually made on the basis of histological examination, and the presence of S-1007,20 and CD1a6,21 by immunohistochemical examination could confirm eosinophilic granuloma.…”

Section: Discussionmentioning

confidence: 99%

“…It accounts for 60-70% of all cases of Langerhans cell histiocytosis and can be seen as solitary or multifocal bone defects 5,6. The radiographic appearance of eosinophilic granuloma in the jaw is quite variable and not specific7 although the lesions usually appear as radiolucent lesions with well-defined borders 5,8.…”

mentioning

confidence: 99%

Eosinophilic granuloma in the anterior mandible mimicking radicular cyst

Lee

et al. 2013

Imaging Sci Dent

View full text Add to dashboard Cite

Eosinophilic granuloma is a common expression of Langerhans cell histiocytosis and corresponds with typical bone lesions. The radiographic appearance of eosinophilic granuloma in the jaw is variable and not specific. It may resemble periodontitis, radicular cyst, or malignancies. The purpose of this report is to describe the characteristic radiographic features of eosinophilic granuloma of a 39-year-old male. The lesion in the anterior mandible was first diagnosed as radicular cyst because the radiographic findings were ovoid radiolucent lesion with well-defined border. However, careful interpretation revealed a non-corticated border and floating tooth appearance that were the characteristic radiographic features for the differential diagnosis. Early clinical signs of eosinophilic granuloma can occur in the jaw and a bony destructive lesion might be mistaken for periodontitis or an odontogenic cystic lesion; therefore, careful interpretation of radiographs should be emphasized.

show abstract

“…The overall consensus on solitary bone lesions is that they only require biopsy and curettage 8 , as in our case. However some cases of spontaneous total remission of EG without any treatment after a needle biopsy are described 8 . Curettage of the lesions could promote an inflammatory response, resulting in the maturation of Langerhans cells, leading to healing 8 .…”

Section: Discussionmentioning

confidence: 99%

Occipital Eosinophilic Granuloma Presenting as Throbbing Headache with a “Bump”

Cherubin

Battistella²,

Calderone

et al. 2005

Rivista di Neuroradiologia

View full text Add to dashboard Cite

A case of occipital eosinophilic granuloma (EG) presenting as right occipital throbbing headache with a “bump” is reported. Even if cranial X-rays and CT scan showed a typical lytic lesion, to make a definite diagnosis of EG histological examination with immunohistochemical detection of S-100 and CD1a antigens was necessary. A total bone scintigraphy ruled out other bone lesions. Treatment of EG depends on the extent of the disease at the time of diagnosis. When no systemic disease is found some authors suggest “wait and see” management. Twelve months after surgery our patient had no recurrences.

show abstract

Eosinophilic granuloma: resolution of maxillofacial bony lesions following minimal intervention Report of three cases and a review of the literature

Cited by 49 publications

References 28 publications

Canine Oral Eosinophilic Granuloma Treated with Electrochemotherapy

Canine Oral Eosinophilic Granuloma Treated with Electrochemotherapy

Eosinophilic granuloma in the anterior mandible mimicking radicular cyst

Occipital Eosinophilic Granuloma Presenting as Throbbing Headache with a “Bump”

Contact Info

Product

Resources

About