Eosinophilic granuloma of the head and neck: CT and MRI features in three cases

Hermans, Robert; Foer, Bert De; Smet, Maria-Helena; Leysen, Joyce; Feenstra, Louw; Fossion, Eric; Baert, Albert

doi:10.1007/bf02017656

Cited by 33 publications

(19 citation statements)

References 13 publications

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“…The lesion usually has sharp, punched-out borders in the outer and inner tables, causing a bevelled edge. There is no sclerosis at the edge of the bony defect [9, 10, 11, 12]. …”

Section: Discussionmentioning

confidence: 99%

Spontaneous Resolution of Calvarial Eosinophilic Granuloma in Children

Oliveira¹,

Steinbok²,

et al. 2003

Pediatr Neurosurg

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Objective: The recommended treatment for solitary calvarial eosinophilic granuloma (EG) is surgical resection by curettage, craniectomy or craniotomy. The purpose of this study was to describe the spontaneous resolution of calvarial EG and discuss ‘observation only’ as an option in the management of this condition. Methods: A retrospective review was performed of children with calvarial EG seen at a tertiary care children’s hospital. Of a total of 17 such patients, four were managed without any intervention and formed the basis of this report. Results: In all four patients treated by ‘observation only’, there was a tender calvarial mass which enlarged rapidly over a few days and then resolved slowly over many weeks. The diagnosis of EG was based on the findings of plain radiographs and/or computed tomography. All masses had resolved by 8 weeks, and the underlying cranial defect filled in spontaneously in all cases. There was no recurrence at follow-up, which ranged from 2 months to 7 years. Conclusions: ‘Observation only’ should be considered as a viable option in the management of children with solitary calvarial masses that have the radiographic features of EG. Consideration should be given to delaying surgical intervention to allow time to see if spontaneous resolution occurs.

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“…The lesion usually has sharp, punched-out borders in the outer and inner tables, causing a bevelled edge. There is no sclerosis at the edge of the bony defect [9, 10, 11, 12]. …”

Section: Discussionmentioning

confidence: 99%

Spontaneous Resolution of Calvarial Eosinophilic Granuloma in Children

Oliveira¹,

Steinbok²,

et al. 2003

Pediatr Neurosurg

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“…Radiographically, the mastoid lesions in LCG syndrome could resemble those induced either by suppurative mastoiditis, cholesteatoma, or osteolytic metastases. Therefore, radiography is not sufficient in diagnosis, and should be followed either by CT or MRI techniques [10]. CT is appropriate to make a precise diagnosis, yet our experience shows that postoperative CT failed to assess the complete state of disease.…”

Section: Discussionmentioning

confidence: 69%

Langerhans' cell granulomatosis in an adult: a 22-year follow up

Gulam

Pegan

Stančić³

et al. 2001

European Archives of Oto-Rhino-Laryngology

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A 57-year-old patient with Langerhans' cell granulomatosis (LCG) is presented. During 22 years of treatment, there were five relapsing infiltrations at different sites of the skull bones, which were treated by surgery, local radiotherapy, and chemotherapy. During the last relapse, the right temporal bone was infiltrated by granuloma and the petrous bone was destroyed with an intimate spread to the internal carotid artery. After two palliative surgical resections and ineffective radiotherapy, 12 cycles of chemotherapy (vinblastine plus prednisolone) were applied and a clinical remission of the disease was achieved. Special attention is paid to the complexity of diagnosis and choice of therapy. It is concluded that the behavior of LCG may change with time, and assume an aggressive form of the disease. Chemotherapy is the treatment of choice for this type of multifocal malignant form of LCG. Prognosis of the disease is unpredictable.

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“…These manifestations can be associated with conductive hearing loss due to erosion of the ossicular chain, polyp formation, otorrhoea or mastoiditis symptomatology. 17,18 • Otological symptoms may be the first sign of leukaemia or Langerhans' cell histiocytosis • In this series, 2.7 per cent of children with acute mastoiditis-like symptoms had a systemic aetiology (i.e. leukaemia or Langerhans' cell histiocytosis) • Such non-infectious 'acute mastoiditis' is a rare diagnostic and therapeutic challenge • In atypical acute mastoiditis, a non-infectious cause should be suspected • Diagnosis is aided by imaging but confirmed by histopathology…”

Section: Temporal Bone Manifestation Of Langerhans' Cell Histiocytosismentioning

confidence: 97%

“…6 In addition, 15-61 per cent of patients with Langerhans' cell histiocytosis have otological manifestations. 3,17 The outer and middle ear are often involved. These manifestations can be associated with conductive hearing loss due to erosion of the ossicular chain, polyp formation, otorrhoea or mastoiditis symptomatology.…”

Section: Temporal Bone Manifestation Of Langerhans' Cell Histiocytosismentioning

confidence: 99%