Eosinophilic granuloma of the gastro-intestinal tract.

Abstract

(1954) felt that gastric granulomata were probably due to foreign-body reactions, and considered that the presence of eosinophils did not justify a diagnosis of eosinophilic granuloma nor an allergic aetiology.

Co-existent eosinophilic gastroenteritis and hypothalamic-pituitary dysfunction

“…Abnormal vitamin B12 absorptive capacity appears to be rare. The present patient showed significant impairment of vitamin B12 absorption reflecting the terminal ileal involvement documented in eosinophilic gastroenteritis (Swarts and Young, 1955;Koneman, Sawyer and Lubchenko, 1959;Higgins, Lamm and Yutzy, 1966;Salmon and Paulley, 1967;Kaplan et al, 1970).…”

Eosinophilic Gastroenteritis

“…The association of peripheral eosinophilia and abdominal symptoms has more recently led to the diagnosis and treatment without operation in this type of case by Higgins et a& (1966) ~ Salmon and Paulley (1967) and Floch (1970). The diagnosis has also been established by smallbowel biopsy (Pitchumoni et alii, 1970).…”

“…Some have been asthmatic (Judd et alii. 1955), and there are patients with a strong familial and constitutional tendency towards allergy such as those described by Spencer et alii (rqso), Frank (1953) and Salmon and Paulley (1967). The presence of eosinophils is not proof of an allergic xtiology, as they feature prominently in a variety of inflammatory conditions.…”

“…Coexistent peptic ulcer is present in a few, and a granuloma is seen to have formed a small tumour in the edges of the gastric ulcer in some. Eosinophilic granulomata have been reported from the pharynx to the rectum (Salmon and Paulley, 1967). I n the small bowel a localized polyp has occurred occasionally, and these patients have often presented with intussusception.…”

“…Nevertheless, the condition is still not widely known, and it is not usually considered in the differential diagnosis of the acute abdomen or in other abdominal disorders (Higgins et a&, 1966 ;Salmon and Paulley, 1967).…”