Eosinophilic gastro-enteritis

Brostoff, Jonathan; Craig, Oscar; Everest, Michael

doi:10.1002/bjs.1800570905

Cited by 10 publications

(3 citation statements)

References 14 publications

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“…The high frequency of serum antibodies to such antigens [28,35,38) indicates recognition of the absorbed antigens by the systemic immune system. Circulating immune complexes were reportedly found after meals in normal and in greater amounts in atopic or IgA-deficient individuals [5,7,32]. The finding of antibodybound dietary antigen in the circulation further suggested the elimination of these antigens by the systemic immune system [8,34].…”

mentioning

confidence: 99%

Passage of Undegraded Dietary Antigen into the Blood of Healthy Adults Further Characterization of the Kinetics of Uptake and the Size Distribution of the Antigen

1986

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The molecular weight distribution of ovalbumin (OA) absorbed into the blood in eight healthy adults after a test meal was analysed by high pressure liquid gel permeation chromatography (HPLC) followed by ELISA for OA. OA was found either as free OA or as aggregates of a size mainly below 700 kD. The addition of OA in vitro to an antibody-containing serum resulted in OA-containing immune complexes (OA-IC) of similar size. The size distribution of serum OA-IC was more heterogeneous late than early in the 7-h observation period. Free OA disappeared at an equal or higher rate than OA-IC when both entities were present in the same individual. The presence of OA-IC was related to the serum IgG antibody levels. IgG, but not IgA or IgM, could be detected in OA-IC (in three individuals) by ELISA. The kinetics of OA appearance was followed for 48 h after a test meal in three individuals. In one person, serum OA reached peak values at 24 h and detectable amounts persisted for 48 h after the test meal. In the other test persons the OA levels peaked earlier. The present study indicates that in healthy adults dietary antigens are absorbed and circulate regularly in minute amounts apparently as native protein and/or as small immune complexes, mostly containing IgG antibodies.

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confidence: 99%

Passage of Undegraded Dietary Antigen into the Blood of Healthy Adults Further Characterization of the Kinetics of Uptake and the Size Distribution of the Antigen

1986

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“…An allergic or immunologic disorder is the most common proposed cause for this disease. A peripheral eosinophilia is reported to occur in 79% of patients [1] and occurred in 96% (24) of our patients. An allergic disorder (asthma, allergic rhinitis, food allergy, atopic dermatitis, eczema, urticaria, and/or medicine allergy) is reported to occur in approximately 50% of patients [2][3][4][5] and was present in 56% (14) of our patients.…”

Section: Clinical Aspectsmentioning

confidence: 44%

“…In the majority of patients, the disease follows a relatively benign course, punctuated by recurrent symptoms controlled by short-term corticosteroid therapy. Few patients are maintained on chronic steroid therapy, and some have self-limited recurrences [23,24]. In addition, the radiographic manifestations may be completely reversible with steroid therapy [8].…”

Section: Clinical Aspectsmentioning

confidence: 99%

Radiographic manifestations of eosinophilic gastroenteritis

et al. 1995

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Eosinophilic gastroenteritis (EG) is a rare inflammatory disease of unknown etiology, characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract. Although little over 250 cases of EG have been reported in the literature, EG is probably more common than reports in the literature would indicate. A retrospective review of 25 patients with EG along with a review of the literature was done to identify clinical, laboratory, radiographic, and therapeutic features. An allergic disorder was present in 14 (56%) and a peripheral eosinophilia was present in 24 (96%) of our patients. The most common radiographic manifestations of the stomach and small bowel included stenosis and fold thickening, respectively. Thirteen patients had esophageal involvement, with the esophageal stricture being the most common abnormality found in these patients. Steroids produced a good therapeutic result in most patients; the remaining patients responded to cromolyn and/or surgery.

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