Eosinophilic gastroenteritis with obstruction

Caldwell, James H.; Mekhjian, Hagop S.; Hurtubise, Paul E.; Beman, Floyd M.

doi:10.1016/0016-5085(78)90134-8

Cited by 56 publications

(4 citation statements)

References 33 publications

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“…In human cases of eosinophilic gastritis, enteritis, colitis, or such complications, the allergic reaction of type-1 hypersensitivity in particular has been postulated as a pathogenic mechanism on morphologic grounds. However, no striking abnormalities were detected in many cases by immunologic studies, including serum immunoglobulin, serum complement, lymphocyte quantitation, or lymphocyte response to nonspecific mitogens (8). Similarly, patients with intestinal allergy often have negative skin tests, low levels of serum IgE, and intestinal allergic reactions thought to be different from classical IgE-mediated reactions (5).…”

Section: X260mentioning

confidence: 99%

Eosinophilic Gastroenterocolitis in Iron Lactate-Overloaded Rats

et al. 1999

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Eosinophilic gastroenterocolitis with peripheral eosinophilia was induced in rats fed a diet containing 2.5% or 5.0% iron lactate for 3 mo. Additional findings consistent with iron overload were also observed. Microscopically, the lesions consisted of eosinophilic infiltrations in the mucosa and submucosa along the whole length of the gastrointestinal tracts, increased surface area of the gastric mucosal propria covered with mucous cells, and increased apoptotic bodies in the gastric glandular neck of rats in the 2.5% and 5.0% groups. An increased number of intraepithelial globule leukocytes in the gastric and intestinal lamina propria was also observed in the 5.0% group. Globule leukocytes in the gastric mucosa contained obviously enlarged granules in their cytoplasm in these rats. The granules of the globule leukocytes were positive for rat mast cell protease II, suggesting the mastocyte origin of these cells. Although severe infiltration of eosinophils and globule leukocytes suggested a type-1 hypersensitivity reaction, other features such as an increasing vascular permeability were not detected. Serum IgE levels in the 5.0% and control groups were <3 ng/ml. Final body weights of male and female rats of the 5.0% group were suppressed to 70% and 90%, respectively, of those of the control rats, whereas food consumption was comparable to that of the control group. The morphologic characteristics of the gastrointestinal lesions and peripheral eosinophilia induced in rats fed iron lactate were very similar to those in some cases of eosinophilic gastroenterocolitis in humans and other animals.

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Section: X260mentioning

confidence: 99%

Eosinophilic Gastroenterocolitis in Iron Lactate-Overloaded Rats

et al. 1999

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“…Pediatric patients of all ages, infancy (2‐4), childhood (5‐7), and adolescence (8), have been reported to have eosinophilic gastroenteritis. The disease is also reported in adults, predominantly in the second to the sixth decades of life (9), with reports of occurrence through the seventh decade (10).…”

Section: Symptomsmentioning

confidence: 99%

Eosinophilic Gastroenteritis

Kelly,

Simpson,

Anderson

2000

J. pediatr. gastroenterol. nutr.

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The goal to create a standardized diagnostic classification scheme of food‐related gastrointestinal hypersensitivity disease syndromes included the diagnosis of eosinophilic gastroenteritis. This article reviews the history of this diagnosis and the current concepts of this complex disorder. The common symptoms from the literature are discussed. Because no standards for this diagnosis exist, the wide variety of diagnostic criteria from the literature are presented. No consistent immunologic abnormalities have been associated with the diagnosis of eosinophilic gastroenteritis in the literature. A review of the current immunologic concepts associated with the diagnosis of eosinophilic gastroenteritis is presented. The history of this disorder, which spans more than 6 decades is also discussed. The contributions made by the original authors during this period are presented. Attention was directed to the variety of clinical features associated with this disorder, but particular attention was paid to the evolution of the pathophysiologic mechanisms proposed. Some of the difficulties associated with the prospective study of patients with eosinophilic gastroenteritis are also discussed. The establishment of appropriate control populations, as well as the fundamental difficulties encountered with the establishment of the certainty of the link between abnormal immunohistochemical findings, and initial clinical symptoms are presented and discussed. A new classification system is proposed for food‐related gastrointestinal hypersensitivity disease syndromes. Age, symptoms, and the region of the gastrointestinal tract involved were the variables that were considered most important by consensus opinion. Finally, recommendations to refocus our collective investigative efforts are presented.

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“…Key Words: Eosinophilic gastrocnteritis-Pyloric stcnosis-Obstruction. 6,7) and may be manifested clinically by gastric outlet or small bowel obstruction (2,3,7). Although eosinophilic gastroenteritis has been reported in children (6,8), it is not a frequently considered diagnosis in infants presenting with pyloric stenosis (9), a common form of gastric outlet obstruction.…”

mentioning

confidence: 99%