Eosinophilic Granuloma of Bone

Sbarbaro, John L.; Francis, Kenneth C.

doi:10.1001/jama.1961.03040460014003

Cited by 40 publications

(6 citation statements)

References 2 publications

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“…These patients developed visceral disease resulting in their death. Review of histologic findings revealed eosinophilic granuloma; however, the disease in these patients exhibited a definitely more aggressive course [178]. Two other patients died of pneumonia, one as a complication of a cauda equina injury from a lesion involving the fifth lumbar vertebra [ 1501 and the other as a complication of increased intracranial pressure, with a lesion noted in the left temporal bone [93].…”

Section: Gross Examination Of Early Lesions Reveals a Soft Brownishmentioning

confidence: 99%

Eosinophilic Granuloma of Bone

Slater

Swarm

1980

Med. Pediatr. Oncol.

116

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Eosinophilic granuloma of bone is an uncommon granulomatous process for which therapy recommendations vary considerably. Consequently, a survey of the world literature from 1940 to 1974 was undertaken in an attempt to develop more concrete guidelines. This survey revealed that the disease manifests itself primarily in males under 20 years of age of all races. The most common symptom is pain, with or without swelling. Multiple sites in a single case are frequent. The clinical course is generally benign, unlike Letterer-Siwe disease or Hand-Schuller-Christian disease. A remission rate of 95% was noted, with relapses usually occurring as distant disease within the first year. Simple excision or curettage was the most common surgical procedure utilized, and radiotherapy doses varied widely. Excellent local control of the disease can be provided using conservative surgery, low-dose irradiation, or both. Morbidity secondary to pathologic fracture or to overly aggressive treatment are the major concerns, not failure to control the disease.

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Section: Gross Examination Of Early Lesions Reveals a Soft Brownishmentioning

confidence: 99%

Eosinophilic Granuloma of Bone

Slater

Swarm

1980

Med. Pediatr. Oncol.

116

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“…In eosinophilic granuloma, lesion margins are irregular and endosteal erosion occurs (e.g. Lichtenstein & Jaffe ; Platt & Eisenberg ; Sbarbaro & Francis ; McCullough ). In renal osteodystrophy, rates of resorption and bone remodelling are increased, resulting in increased overall cortical porosity (e.g.…”

Section: Discussionmentioning

confidence: 99%

Non-traumatic bone infection in stegosaurs from Como Bluff, Wyoming

Redelstorff

Hayashi

Rothschild

et al. 2015

LET

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Palaeopathologies are relatively common in the fossil record; however, bone histological analyses of these are rare as they are more commonly discovered and described using radiological scans. Here, we describe the bone microstructure of infectious abscesses (osteomyelitis) in the long bones of two Stegosaurus individuals from the Como Bluff area of the Late Jurassic Morrison Formation. Multiple lytic, geographical lesions filled with reactive lamellar bone occur in a femur of a juvenile specimen. A single lesion was found in an adult tibia. This lesion is characterized by the presence of spiculated periosteal reactive growth perpendicular to the bone surface and the formation of new trabeculae within the lesion.

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“…As the true nature, etiology, and pathogenesis of histiocytosis X have not been elucidated, variable treatment mo-daLties have been proposed (Sedano et al 1969, Soskolne et al, 1977, Lin et al 1979, Patrikiou et al 1984, Zuendel et al, 1984, Excellent response has been reported in 28 cases of eosinophilic granuioma of bone approached by a variety of treatment modalities, including surgery and radiation (McGavran & Spady I960). Zuendel et al (1984) reported that bony lesions of histiocytosis X were sensitive to various treatments and that conservative, individually planned therapy was most appropriate, Sbarbaro & Francis (1961) as well as Patrikiou et al (1984) stated that curettage should be the preferred treatment for a solitary lesion of eosinophilic granuloma and that radiotherapy or chemotherapy should be reserved for surgically inaccessible regions, while Ochsner (1966) noted a favorable response after radiotherapy. In general, surgical curettage is recommended for the treatment of jaw lesions while radiotherapy and chemotherapy should be reserved for lesions which are either too numerous or inaccessible to surgery (Johnson & Mohnac 1967.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic problems of periodontitis‐like lesions caused by eosinophilic granuloma

Nicopoulou-Karayianni¹,

Mombelle²,

Lang³

1989

J Clinic Periodontology

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Eosinophilic granuloma is the localized and mildest form of histiocytosis X. It is a destructive osseous lesion characterized by large numbers of eosinophils and histiocytes. The etiology of the disease is unknown. Frequently the jaws, including the periodontium, are involved and the disease stimulates severe localized periodontitis. A case of eosinophilic granuloma of the jawbone is presented. The pertinent clinical features are emphasized and possible problems in the interpretation of clinical periodontal features are discussed.

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Eosinophilic Granuloma of Bone

Cited by 40 publications

References 2 publications

Eosinophilic Granuloma of Bone

Eosinophilic Granuloma of Bone

Non-traumatic bone infection in stegosaurs from Como Bluff, Wyoming

Diagnostic problems of periodontitis‐like lesions caused by eosinophilic granuloma

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