Eosinophilic Granuloma of Bone

Slater, James M.; Swarm, Orval J.

doi:10.1002/mpo.2950080208

Cited by 116 publications

(45 citation statements)

References 95 publications

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“…Surgical curettage has been recommended for those lesions in accessible areas. Although aggressive surgical curettage should be performed, total removal of the lesion has not always been necessary for a favorable response [19]. The use of an ultrasonic surgical aspirator in the extirpation of an EG of the mandible can be useful in avoiding major nerves and vessels [20].…”

Section: Discussionmentioning

confidence: 99%

Solitary Eosinophilic Granuloma of Mandibular Condyle: Literature Review and Report of a Rare Case

Guruprasad

Chauhan

2012

J. Maxillofac. Oral Surg.

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Solitary eosinophilic granuloma (EG) is traditionally included as 1 of the 3 clinical manifestations of the histiocytosis-X group of diseases, which also encompasses Hand-Schuller-Christian disease and Letterer-Siwe disease. EG is the most common lesion in the spectrum of disorders under the classification of Langerhans cell histiocytosis. EG represents the monostotic form of the disease with the head and neck region representing the most common site of initial presentation. We report a rare case of solitary EG involving mandibular condyle in a 49-yearold male patient, which is the first reported case in Indian literature.

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Section: Discussionmentioning

confidence: 99%

Solitary Eosinophilic Granuloma of Mandibular Condyle: Literature Review and Report of a Rare Case

Guruprasad

Chauhan

2012

J. Maxillofac. Oral Surg.

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“…Conventional imaging modalities such as skeletal surveys and technician bone scans have been the standard methods of determining sites of Langerhans cell histiocytosis (LCH) in the bones [1,2]. Reports comparing the sensitivity of bone scans versus skeletal surveys have conflicting views on which modality is best [3].…”

Section: Introductionmentioning

confidence: 99%

Comparison of FDG‐PET scans to conventional radiography and bone scans in management of Langerhans cell histiocytosis

Phillips

Allen

Gerson³

et al. 2008

Pediatric Blood & Cancer

183

105

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BackgroundWe evaluated the effectiveness of FDG‐PET scans in identifying sites of active disease and assessing response to therapy in patients with Langerhans cell histiocytosis (LCH). Changes in standardized uptake value (SUV) indicated increased or decreased disease activity before changes are evident by plain films or bone scans.MethodsOne hundred and two PET scans for 44 patients (41 children, 3 adults) with biopsy‐proven LCH were compared with 83 corollary imaging modalities and were rated for overall clinical utility: false positive or negative (“inferior”), confirming lesions identified by another imaging modality (“confirmatory”), or showing additional lesions, response to therapy or recurrence of disease activity (“superior”), in comparison to bone scans, MRI, CT or plain films.ResultsFDG‐PET was rated superior in that 90/256 (35%) new, recurrent, or lesions responding to therapy were identified via change in standard uptake value (SUV) before other radiographic changes. PET scans confirmed active LCH in 146/256 (57%). FDG‐PET was superior to bone scans in that 8/23 (34%) lesions, 11/53 (21%) comparisons to lesions found by MRI, 13/64 (20%) CT, and 58/116 (50%) plain films. PET scans confirmed lesions found by: 14/23 (61%) bone scans, 33/53 (62%) MRI, 45/64 (65%) CT, and 54/116 (46%) of plain films.ConclusionsWhole body FDG‐PET scans can detect LCH activity and early response to therapy with greater accuracy than other imaging modalities in patients with LCH lesions in the bones and soft tissues. Whole‐body FDG‐PET scanning is an important and informative study at diagnosis and for following disease course in patients with LCH. Pediatr Blood Cancer 2009;52:97–101. © 2008 Wiley‐Liss, Inc.

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“…Usually, eosinophilic granuloma has either unifocal or multifocal lesions; Hand-Schüller-Christian disease is a subset of multifocal eosinophilic granuloma with a triad of signs (lytic skull lesions, exophthalmos and diabetes insipidus); Letterer-Siwe disease is a more fulminate systemic histiocytosis, primarily involving soft tissue sites, such as malignant lymphoma of infancy [1]. Slater and Swarm [3]reported that the skull was the most common site of eosinophilic granuloma (43%). The femur is the next most common site.…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic Granuloma with Acute Epidural Hematoma

Cho¹,

Liau²,

Chiang³

2001

Pediatr Neurosurg

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The most common symptoms of eosinophilic granuloma are local tenderness and an enlarged skull mass. The presence of epidural hematoma is a very rare symptom of eosinophilic granuloma. To our knowledge, this is only the second reported case of eosinophilic granuloma with epidural hematoma. A 2-year-old boy with a soft tumor on the occipital scalp, palpable at the age of 3 months, yet with no obvious history of trauma, was admitted due to a sudden onset of loss of consciousness. A brain computed tomography scan showed a lytic lesion on the occipital skull with a large epidural and subcutaneous hematoma, causing brain compression. He underwent an emergency craniectomy with removal of both the tumor and hematoma. The patient regained consciousness and had no residual neurological damage. Pathological reports showed abnormal proliferation of Langerhans’ cells, eosinophilic cells and multinucleated cells. A whole-body bone nuclide scan revealed no other bone lesions. The patient was discharged uneventfully. The causes of hematomas are not very clear. They may be due to tumor necrosis or minor trauma. In our presented case, the cause of the epidural hematoma may have been tumor bleeding which ruptured into the epidural space. A solitary eosinophilic granuloma of the skull with acute epidural hematoma and loss of consciousness is extremely uncommon. Craniectomy with removal of the tumor and hematoma decompression may produce good results.

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Eosinophilic Granuloma of Bone

Cited by 116 publications

References 95 publications

Solitary Eosinophilic Granuloma of Mandibular Condyle: Literature Review and Report of a Rare Case

Solitary Eosinophilic Granuloma of Mandibular Condyle: Literature Review and Report of a Rare Case

Comparison of FDG‐PET scans to conventional radiography and bone scans in management of Langerhans cell histiocytosis

Eosinophilic Granuloma with Acute Epidural Hematoma

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