Eosinophilic Gastroenteritis

Klein, Neil C.; Hargrove, Richard; Sleisenger, Marvin H.; Jeffries, Graham H.

doi:10.1097/00005792-197007000-00003

Cited by 565 publications

(397 citation statements)

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“…Sometimes it is difficult to obtain a sufficient pathological specimen to make a definite diagnosis of HES. Klein et al reported that there are some different types of eosinophilic infiltration (11). It is suggested, that in those cases, as in the present case, the eosinophilic infiltration mainly involved the deeper layers of the gastrointestinal tract.…”

Section: Discussionsupporting

confidence: 56%

A Rare Case of Idiopathic Hypereosinophilic Syndrome Involving the Oral Cavity Associated with the Esophagus and Gastrointestinal Tract

et al. 2004

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We report the rare case of HES involving oral cavity associated with esophagus, and gastrointestinal tract, which we succeeded in diagnosing precisely through a biopsy specimen obtained from the lip. A 64-year-old man had dysphagia, swelling of the oral mucosa and the posterior cervical muscles, accompanied by an abdominal pain and diarrhea. Peripheral blood cell count showed marked eosinophilia. Case ReportA 64-year-old man had a 9-day history of dysphagia and swelling of the oral mucosa and posterior cervical muscles. Also he had abdominal pain and diarrhea for 4 days.He had bronchial asthma for the previous 1 year, which was controlled with regular inhalations of budesonide and oral theophyline and occasional inhalations of salbutamol. There were no recent infections or relevant travel history.At admission, he was unwell with a low-grade fever up to 37.1°C, swelling of oral mucosa (Fig. 1), and frequent bowel movement. Because of dysphagia and severe swelling of the oral mucosa, he could not eat any food.Laboratory examinations revealed an excess of white blood cells, 17,800/mm , with marked eosinophilia, and 52.7% eosinophils. Serum IgE concentrations were also elevated at 1,785 IU/ml (normal <310 IU/ml). Radioallergosorbent tests for multiple allergens were negative.Other normal laboratory values included antinuclear antibody, anti-DNA antibody, and complement titer.

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Section: Discussionsupporting

confidence: 56%

A Rare Case of Idiopathic Hypereosinophilic Syndrome Involving the Oral Cavity Associated with the Esophagus and Gastrointestinal Tract

et al. 2004

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“…[19] Furthermore, Charcot-Leyden crystals, remnants of eosinophil degranulation, are commonly found on microscopic examination of stools obtained from patients with eosinophilic gastroenteritis. [20,21] Evidence has also supported the association between eosinophils and the enteric nervous system, contributing to the pathogenesis of disease. A recent human study showed the close association of mucosal eosinophils and their granule proteins with the myenteric ganglia.…”

Section: Function Of Eosinophilia In the Gastrointestinal Systemmentioning

confidence: 96%

Gastrointestinal Eosinophilia

Zuo

Rothenberg

2007

Immunology and Allergy Clinics of North America

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“…In the healthy colon, eosinophil counts range from 5 up to 35 per high-powered field, with a proximal to distal gradient along the colon [Lowichik and Weinberg, 1996]. Hence, the diagnosis is contingent upon histological evidence of excessive [Blackshaw and Levison, 1986;Spry, 1984;Cello, 1979;Klein et al 1970] Eosinophilic proctocolitis (allergic proctocolitis or milk-protein proctocolitis) is an entity that has been described classically in infants associated with ingestion of cow's milk and soy proteins [Lake, 2000;Raafat et al 1990]. Thus, a bimodal age distribution of EC is apparent: an infantile form presenting at 60 days and an adolescent form later in life [Odze et al 1995].…”

Section: Eosinophilic Esophagitismentioning

confidence: 99%

Eosinophilic colitis: epidemiology, clinical features, and current management

Alfadda

Storr

Shaffer

2010

Therap Adv Gastroenterol

122

137

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Primary eosinophilic gastrointestinal disorders (EGIDs) represent a spectrum of inflammatory gastrointestinal disorders in which eosinophils infiltrate the gut in the absence of known causes for such tissue eosinophilia. EGIDs can be subgrouped as eosinophilic esophagitis (EE), eosinophilic gastroenteritis (EG), and eosinophilic colitis (EC). The least frequent manifestation of EGIDs is EC. EC is a heterogeneous entity with a bimodal age distribution, presenting with either an acute self-limited bloody diarrhea in otherwise healthy infants or as a more chronic relapsing colitis in young adults. The pathophysiology of primary EC appears related to altered hypersensitivity, principally as a food allergy in infants and T lymphocytemediated (i.e. non-IgE associated) in young adults. In adults, symptoms include diarrhea, abdominal pain, and weight loss. Endoscopic changes are generally modest, featuring edema and patchy granularity. Although standardized criteria are not yet established, the diagnosis of EC depends on histopathology that identifies an excess of eosinophils. Therapeutic approaches are based on case reports and small case series, as prospective randomized controlled trials are lacking. Eosinophilic colitis in infants is a rather benign, frequently food-related entity and dietary elimination of the aggressor often resolves the disorder within days. Adolescent or older patients require more aggressive medical management including: glucocorticoids, antihistamines, leukotriene receptors antagonists as well as novel approaches employing biologics that target interleukin-5 (IL-5) and IgE. This review article summarizes the current knowledge of EC, its epidemiology, clinical manifestations, diagnosis, and treatment.

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Eosinophilic Gastroenteritis

Cited by 565 publications

References 0 publications

A Rare Case of Idiopathic Hypereosinophilic Syndrome Involving the Oral Cavity Associated with the Esophagus and Gastrointestinal Tract

A Rare Case of Idiopathic Hypereosinophilic Syndrome Involving the Oral Cavity Associated with the Esophagus and Gastrointestinal Tract

Gastrointestinal Eosinophilia

Eosinophilic colitis: epidemiology, clinical features, and current management

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