Eosinophilic Esophagitis

Aceves, Seema S.

doi:10.1016/j.iac.2014.09.007

Cited by 23 publications

(35 citation statements)

References 129 publications

(163 reference statements)

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“…This multidisciplinary approach is important to prevent both short-and long-term complications of this chronic disease and treatment-related adverse effects [39].…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Esophagitis: Demographic, Clinical, Endoscopic, Histologic, and Atopic Characteristics of Children and Teenagers in a Region in Central Spain

Torrijos

Miranda

Palencia

et al. 2017

J Investig Allergol Clin Immunol

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Background and objective: Eosinophilic esophagitis (EoE) is an increasingly prevalent chronic inflammatory disease of the esophagus with an immunoallergic etiology. Few studies have been published on EoE in children and adolescents. The objective of this study was to analyze the demographic, clinical, serologic, endoscopic-histologic, and atopic characteristics of pediatric patients with EoE and to identify atopic and digestive comorbidities. Methods: We conducted a prospective observational study in children and adolescents (<16 years) assessed in a specialized multidisciplinary EoE unit in a tertiary referral hospital in a central region of Spain between 2011 and 2015. Results: Thirty-five patients were included in the study. Twenty-eight (80%) were male. The mean age was 9.6 years, 83% were atopic, and 28% reported a family history of atopy. The most common symptom was dysphagia (51%). Eosinophilia was detected in the blood of 60% of patients. Eosinophil cationic protein and total IgE were elevated in 88% and 77% of patients, respectively. The most frequent endoscopic finding was linear grooves (57%). Skin tests with aeroallergens were positive in 82% of patients (pollen 62% and food 60%). The main atopic comorbidities were asthma (48%) and rhinoconjunctivitis (37%). Digestive diseases were more often associated with gastritis and Helicobacter pylori infection (17%). Conclusions: Our results are similar to those previously reported. EoE is more common in boys and in individuals with a history of atopy and sensitization to airborne allergens and food. These results support the consideration of EoE as an atopic disease and underline the important role of allergists in early diagnosis and treatment.

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“…This multidisciplinary approach is important to prevent both short-and long-term complications of this chronic disease and treatment-related adverse effects [39].…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Esophagitis: Demographic, Clinical, Endoscopic, Histologic, and Atopic Characteristics of Children and Teenagers in a Region in Central Spain

Torrijos

Miranda

Palencia

et al. 2017

J Investig Allergol Clin Immunol

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“…1 EoE pathogenesis is driven by thymic stromal lymphopoeitin (TSLP) produced by activated epithelial cells, and IL-5 and IL-13 produced by inflammatory cells. Production of IL-5 results in esophageal eosinophilia and IL-13 induces EoE-specific epithelial gene expression and remodeling changes such as angiogenesis.…”

Section: To the Editormentioning

confidence: 99%

“…Indeed, TSLP is highly expressed in EoE. 1, 5 Since ILC2s are not antigen specific, activation of ILC2s via EoE-relevant cytokines may represent an antigen-independent mechanism for propagation of chronic esophageal eosinophilia and structural changes in EoE.…”

Section: To the Editormentioning

confidence: 99%

Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis

Doherty

Baum

Newbury

et al. 2015

Journal of Allergy and Clinical Immunology

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SHORT SUMMARY Group 2 innate lymphoid cells (ILC2s) produce high levels of IL-5 and IL-13, both of which are important pathogenic mediators in eosinophilic esophagitis (EoE). ILC2s have not been previously described in EoE. Our study demonstrates the novel finding that ILC2s are increased in esophageal biopsies from EoE patients with active disease compared with inactive EoE and non-diseased controls, implicating these cells in EoE pathogenesis.

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“…Along with aeroallergens, food antigenic triggers exist. These include milk and wheat, which are the most common triggers, and egg, soy, meats, grains, peanuts/tree nuts, fish, and shellfish [21]. It is believed that the mechanism in which EoE occurs is by food or environmental allergens contacting a possible leaky esophageal epithelium and triggering a T-helper 2 (Th2) cell-mediated immune response (involving interleukin [IL]-4, IL-5, IL-9 and IL-13).…”

Section: Pathogenesismentioning

confidence: 99%