Eosinophilic cystitis mimicking bladder tumor

Werbrouck, C; Marrannes, J; Verhamme, Lieven; Steenkiste, Edwin; Laridon, E; B, Van Holsbeeck

doi:10.5334/jbr-btr.141

Cited by 4 publications

(5 citation statements)

References 1 publication

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“…EC is a rare condition that can mimic invasive bladder cancer symptoms. EC diagnosis may be considered if a bladder tumor is associated with eosinophilia ( 20 ). The eosinophil count in the blood was significantly increased in each of the 2 cases and a bone marrow biopsy revealed increased eosinophils.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic cystitis in children: A case report

Ning

et al. 2018

Exp Ther Med

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The aim of the present case report was to investigate the clinical features, pathological examination and treatment of eosinophilic cystitis (EC) in children. Two cases of EC were reported and reviewed from January 2016 to March 2017. Case 1 (male; 6 years old) had intermittent hematuria, frequent urination, urgent urination, difficulty in urination and abdominal pain. Case 2 (male; 7 years old) had frequent urination, urgent urination, urinary pain, dysuria and suprapubic pain with no hematuria. One patient had a history of allergies and both patients underwent a cystoscope biopsy. Blood eosinophils were clearly increased and a bone marrow biopsy examination revealed that marrow eosinophils were also increased in both cases. The urine culture results were negative. Ultrasonography and computed tomography revealed uneven thickening of the bladder wall and diffusive mucosal lesions. Cystoscopy revealed that the bladder volume became smaller and the mucosa at the bladder floor and neck was red. Lesions were biopsied through the urethra and the following characteristics were observed: Congestion and edema of the bladder mucosa, infiltration of the blood vessels and eosinophils in the muscular layer, accompanied by focal muscle necrosis. Patient 1 was administered anti-inflammatory and cetirizine hydrochloride treatments, followed by 6 weeks of prednisone dose-reduction therapy. Patient 2 was administered antibiotics and cetirizine hydrochloride. Following 6-month follow-ups, abnormal voiding symptoms had disappeared in each case. Ultrasonography and computed tomography revealed no bladder wall thickening or space-occupying lesions. EC in children is rare and easily misdiagnosed as nonspecific bladder inflammation or bladder occupying lesions. Cystoscopy and biopsy are necessary to diagnose EC and conservative treatments with anti-inflammatory, anti-allergic and cortical hormone nonspecific treatments are suggested.

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Section: Discussionmentioning

confidence: 99%

Eosinophilic cystitis in children: A case report

Ning

et al. 2018

Exp Ther Med

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“…There is no consensus on the treatment of EC, medical treatments such as glucocorticoids, antihistamines, and antibiotics can be regarded as the initial treatment [ 11 ]. The recurrence of those patient who treated with medicine was 17%, whereas that was only 2.6% who treated with surgery [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic cystitis complicated with cystitis glandularis: a case report

Chen

Zeng

et al. 2022

BMC Urol

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Background Eosinophilic cystitis (EC) is a rare inflammatory disease characterized by the gathering and infiltration of numerous eosinophilia (EOS) in the bladder wall. Because of Few cases of EC have been reported globally, the epidemiology of EC is not well known. We report herein the details of one very scarce case of large tumor-like eosinophilic cystitis complicated with cystitis glandularis (CG) diagnosed by biopsy. Case presentation A 45-year-old Chinese man was referred to our hospital for the treatment of right lumbago and odynuria. Ultrasound examination indicated the low echo on the right portion wall and the neck of the bladder. Computed tomography showed a remarkable enhancing large mass that measured 5.0 cm × 2.3 cm located on the right portion of the bladder with undefined margin. For further treatment, diagnostic transurethral resection of the bladder was performed, the postoperative histopathological diagnosis was EC complicated with CG. After transurethral resection, antibiotics, glucocorticoids, and antihistamines were treated. The patient recovered uneventfully and was discharged on postoperative day 8 without evidence of recurrence followed-up for 6 months. Conclusion Large tumor-like eosinophilic cystitis complicated with cystitis glandularis is rare, malignant tumors need to be ruled out. We deem that prompt biopsy led to the exact diagnosis, appropriate treatment led to better prognosis.

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“…There is no definite curative treatment for EC, but medical treatments such as corticosteroids, antihistamines, and antibiotics can be considered as the primary treatment [ 3 – 5 , 7 , 14 – 16 ]. Corticosteroids can help control inflammation and symptoms, and antihistamines can help suppress the inflammatory reaction, which inhibits the formation of immune complexes.…”

Section: Discussionmentioning

confidence: 99%

“…If corticosteroids or antihistamines could not resolve EC, surgical treatment is also an option [ 1 , 5 , 7 , 16 – 18 ]. Surgical treatment not only has a high treatment success rate, but also a low recurrence rate [ 4 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

A rare case of eosinophilic cystitis involving the inside and outside of the urinary bladder associated with an infected urachal cyst

et al. 2021

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Background Eosinophilic cystitis is a rare inflammatory disease of the bladder characterized by eosinophilic infiltration of the bladder wall. Most Eosinophilic cystitis cases present with mucosal lesions of the urinary bladder. We present a very rare case of large mass-forming eosinophilic cystitis, involving the inside and outside of the bladder associated with an infected urachal cyst. Case presentation A 59-year-old man presented with gross hematuria, fever, dysuria, and suprapubic pain. Computed tomography showed a heterogeneously enhancing mass that measured 7.6 cm × 4 cm located on the anterosuperior portion of the bladder with an internal fluid collection. Cystoscopy revealed a raspberry-like mass lesion on the bladder dome. Transurethral resection of the bladder was initially performed. The mass lesion protruding from inside the bladder was removed, and pus-like fluid was drained. The pathologic diagnosis was eosinophilic cystitis. Follow-up computed tomography showed a remnant mass outside the bladder and urachal cyst. To eliminate the remnant lesion, robot-assisted partial cystectomy was performed. The patient showed no evidence of recurrent disease on follow-up cystoscopy and computed tomography for up to 2 years. Conclusions Clinicians should consider the possibility of eosinophilic cystitis in patients who present with hematuria, fever, and suprapubic pain and have both intravesical and extravesical masses.

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Eosinophilic cystitis mimicking bladder tumor

Cited by 4 publications

References 1 publication

Eosinophilic cystitis in children: A case report

Eosinophilic cystitis in children: A case report

Eosinophilic cystitis complicated with cystitis glandularis: a case report

A rare case of eosinophilic cystitis involving the inside and outside of the urinary bladder associated with an infected urachal cyst

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