Eosinophil-Rich CD30+ Lymphoproliferative Disorder of the Oral Mucosa

Alobeid, Bachir; Pan, Langxing; Milligan, Laura; Budel, Leo M.; Frizzerà, Glauco

doi:10.1309/jqfxpnd6dblf6b9u

Cited by 55 publications

(41 citation statements)

References 29 publications

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“…It has been suggested that delayed healing of EU is due to lack of TGF-α and TGF-β release by infiltrating eosinophils [16]. EU is considered the counterpart of cutaneous CD30+ lymphoproliferative disease [12,44,45]. The immunohistochemical and molecular biology studies demonstrating abundant oligoclonal CD30+ cells in the present case is in favor of this assumption.…”

Section: Discussion and Reviewmentioning

confidence: 63%

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

Abdel-Naser¹,

Tsatsou²,

Hippe³

et al. 2011

Dermatology

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Eosinophilic ulcer of the oral mucosa is a benign lesion of unclear pathogenesis mostly affecting the tongue. It has been suggested to represent a reactive pattern to several stimuli. We report on a 12-year-old boy who presented with a painless infiltrating ulcer on the gingiva of the lower jaw, which was covered by necrotic yellowish slough. There were no pathologic features of the jawbones or regional lymph nodes. Histopathological, immunohistochemical and gene rearrangement studies were in agreement with eosinophilic ulcer with predominant oligoclonal CD3+ and CD30+ T lymphocytes expressing the Epstein-Barr virus membrane protein. The ulcer resolved within 4 weeks and follow-up for 3 years revealed no evidence of recurrence. Epstein-Barr virus may have played a role in triggering this reactive lymphoproliferative disorder.

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Section: Discussion and Reviewmentioning

confidence: 63%

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

Abdel-Naser¹,

Tsatsou²,

Hippe³

et al. 2011

Dermatology

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“…The role of trauma in its etiology remains equivocal. 5 The factors that have been implicated in the etiology of cutaneous LyP include the presence of a strong repetitive but unknown antigenic stimuli, arthropod bites, Epstein-Barr virus infection, and predisposing benign or malignant skin conditions. 12,14,15 It is not known if any of these factors play a role in the etiology of oral LPDs.…”

Section: Discussionmentioning

confidence: 99%

CD30-Positive T-Cell Lymphoproliferative Disorder of the Oral Mucosa—An Indolent Lesion: Report of 4 Cases

et al. 2008

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Four cases of CD30-positive T-cell lymphoproliferative disorder (CD30+ LPD) of the oral mucosa are described. This article aims to draw attention to this entity and to emphasize its usual benign clinical behavior despite its resemblance to T-cell lymphoma. All the patients were adults. Three of the lesions were on the dorsal surface of the tongue and 1 affected the buccal mucosa. All biopsies showed a dense lymphoid infiltrate composed of CD30+ atypical T cells with a polymorphous infiltrate in the background, which included eosinophils. In 1 case, monoclonal T-cell expansion was detected by molecular techniques. Three cases tested for Epstein-Barr virus were all negative. It is concluded that primary CD30+ T-cell LPD of the oral mucosa can be regarded as the oral counterpart of cutaneous CD30+ LPD such as lymphomatoid papulosis or anaplastic large cell lymphoma. Recognition of the condition is important to avoid overtreatment.

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“…It has been suggested that some cases of TUGSE may represent a CD30+ lymphoproliferative disorder. 16,17 CD30+ is a transmembrane glycoprotein commonly expressed on activated B and T lympocytes. The term ''atypical histiocytic granuloma'' has been used to describe a TUGSE-like lesion that manifests histologic characteristics of lymphoproliferative disease but presents with benign clinical course.…”

Section: Discussionmentioning

confidence: 99%

Traumatic Ulcerative Granuloma With Stromal Eosinophilia: A Lesion With Alarming Histopathologic Presentation and Benign Clinical Course

Gagari

Stathopoulos

Katsambas

et al. 2011

The American Journal of Dermatopathology

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Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a chronic, benign, self-limiting lesion of the oral mucosa. Clinically, the ulceration is characterized by the presence of indurated elevated borders and may resemble pyogenic granuloma or even squamous cell carcinoma of the mouth. Pathogenesis of the lesion is unclear. Although it had been suggested that TUGSE may represent a CD30+ lymphoproliferative disorder, this theory is currently not supported by evidence. We are presenting a classic example of TUGSE, its clinical course, differential diagnosis, and treatment.

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Eosinophil-Rich CD30+ Lymphoproliferative Disorder of the Oral Mucosa

Cited by 55 publications

References 29 publications

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

CD30-Positive T-Cell Lymphoproliferative Disorder of the Oral Mucosa—An Indolent Lesion: Report of 4 Cases

Traumatic Ulcerative Granuloma With Stromal Eosinophilia: A Lesion With Alarming Histopathologic Presentation and Benign Clinical Course

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