Eosinophil–Epithelial Cell Interactions Stimulate the Production of MUC5AC Mucin and Profibrotic Cytokines Involved in Airway Tissue Remodeling

Abstract

The results of this study indicate that eosinophil-epithelial cell interactions are important in the pathogenesis of tissue remodeling of eosinophil-predominant airway inflammation such as occurs in nasal polyposis and bronchial asthma.

Chronic Rhinosinusitis without Nasal Polyps

“…28,57–60 Glandular hypertrophy and mucous secretion in the airway mucosa are likely to be mediated by the cytokines, tumor necrosis factor (TNF)-α, IL-8 and IL-13. 61–63 MUC5AC and MUC5B are the main secreted mucins in the human airway, with MUC5A produced primarily by goblet cells. 64 Viral and bacterial components up-regulate mucin mRNA expression and stimulate mucin secretion in goblet cells.…”

“…67,68 Eosinophil-epithelial cell interaction also augments the secretion of MUC5AC, PDGF-AB, VEGF, TGF-β, and IL-8 in culture supernatants. 63 …”

miR-143 inhibits interleukin-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients by targeting IL13Rα1

“…Additionally, as the first line of defense against inhaled antigens, nasal epithelial cells (NECs) play a pivotal role in the pathogenesis of AR. These cells can regulate the degree of the inflammatory reaction in the nasal mucosa by interacting with dendritic cells to induce antigen presentation, by releasing many chemokines to recruit effector cells, and by secreting various growth factors to promote airway remodeling [3][4][5]. Therefore, NECs act as critical initiators and mediators of nasal allergic inflammation and are considered as novel therapeutic targets for the development of anti-allergic medicines.…”

Editorial: Insights into Disease Pathogenesis and Novel Therapeutics

“…A separate study in this issue shows that eosinophil-epithelial cell interactions result in proinflammatory cytokine release and tissue remodeling that may contribute to ongoing disease. 2 In addition, Gunel et al 3 have shown that P-glycoprotein is upregulated in eosinophilic CRS, and now they are able to link this to osteitis. 2 Aside from eosinophilic inflammation, further study into T-cells and their function in sinus inflammation continues.…”

“…2 In addition, Gunel et al 3 have shown that P-glycoprotein is upregulated in eosinophilic CRS, and now they are able to link this to osteitis. 2 Aside from eosinophilic inflammation, further study into T-cells and their function in sinus inflammation continues. T lymphocytes have a known function in the inflammatory process in allergic rhinitis and asthma, and their role in particular CRS subtypes has been a hot topic for recent study.…”