Eosinopenia, an early marker of increased mortality in critically ill medical patients

Abidi, Khalid; Belayachi, Jihane; Derras, Youssef; khayari, Mina El; Dendane, Tarek; Madani, N.; Khoudri, Ibtissam; Zeggwagh, Amine Ali; Abouqal, Rédouane

doi:10.1007/s00134-011-2170-z

Cited by 85 publications

(89 citation statements)

References 37 publications

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“…We additionally evaluated the relationship of each WBC subtype with mortality, which was not the same as the AKI results. The effects of neutropenia, lymphopenia, and eosinopenia on mortality support recent findings, although the study settings are not exactly same (Knaus et al 1985;Felmet et al 2005;Kuderer et al 2006;Ducloux et al 2010;Abidi et al 2011;Merino et al 2012). Based on the observations of the study, the correlation with mortality in leukopenia may be attributable to neutropenia and lymphopenia, whereas the correlation in leukocytosis may be attributable to the composite outcome of all WBC subtypes.…”

Section: Discussionsupporting

confidence: 65%

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U-Shape Relationship of White Blood Cells with Acute Kidney Injury and Mortality in Critically Ill Patients

Han

Ahn

Ryu

et al. 2014

Tohoku J. Exp. Med.

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Low or high counts of white blood cells (WBCs) and WBC subtypes can be a predictor of morbidity and mortality in several clinical settings. However, the correlations of WBC and its subtypes with acute kidney injury (AKI) and mortality remain unresolved in critically ill patients. The counts of WBC and subtypes, such as neutrophil, lymphocyte, monocyte, and eosinophil, were measured in 2,079 patients admitted to the intensive care unit (ICU) from June 2004 through June 2010. The non-linear relationship between WBC counts and AKI risk was initially explored by a restricted cubic spline analysis. The odds ratios (ORs) for AKI and 1-year mortality were calculated after adjustment for multiple covariates. The relationship between WBC counts and AKI risk was U-shaped. Accordingly, we divided patients into quintiles according to the counts of WBC or subtypes. The 1 st and 5 th quintiles of WBC counts had greater ORs for AKI (1.42 and 2.05, respectively) and mortality (1.40 and 1.36, respectively) compared with the 3 rd quintile. After stratification by WBC subtype, the 5 th quintile of neutrophil counts and the 1 st quintiles of lymphocyte and monocyte counts tended to have higher ORs for AKI (1.69, 1.40, and 1.77, respectively). For mortality, the 1 st quintiles of neutrophil, lymphocyte, and eosinophil counts were associated with higher mortality compared with the 3 rd quintile (the ORs were 1.48, 1.57, and 1.42, respectively). Both leukopenia and leukocytosis are associated with AKI and mortality risk in critically ill patients. This result may be attributable to the change in the subtype counts.

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Section: Discussionsupporting

confidence: 65%

“…Previously, counts of WBC and its subtypes have been documented to be a predictor of morbidity and mortality in several clinical settings (Knaus et al 1985;Felmet et al 2005;Abidi et al 2011;Merino et al 2012). These components are one of the immunologic factors that play a pivotal role in most processes of organ damage (Deitch 1992).…”

Section: Introductionmentioning

confidence: 99%

U-Shape Relationship of White Blood Cells with Acute Kidney Injury and Mortality in Critically Ill Patients

Han

Ahn

Ryu

et al. 2014

Tohoku J. Exp. Med.

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“…This finding was concordant with the results for our patient population. Concerning the severity of illness, the APACHE II scores reported in our earlier study [32] were within the range of 13-20, which has been observed in developing countries [29][30][31]. In addition, the cost of treating a patient per day in our ICU was $180.…”

Section: Discussionmentioning

confidence: 78%

Determinants and outcomes associated with decisions to deny or to delay intensive care unit admission in Morocco

Louriz¹,

Abidi²,

Akkaoui³

et al. 2012

Intensive Care Med

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“…The findings of the present study are consistent with that of Khalid Abidi et al (80% Sensitivity and 80% specificity). 12 In the present study, positive predictive value 82.2%, negative predictive value 95.4% is seen for eosinopenia. This indicates eosinophil count is better diagnostic and prognostic marker of sepsis.…”

Section: Eosinophil Countmentioning

confidence: 49%

Role of eosinophil count and neutrophil: lymphocyte count ratio as prognostic markers in patients with sepsis

Hota¹,

Reddy²

2017

Int Surg J

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Background: Several biomarkers, such as C-reactive protein (CRP) and Procalcitonin have been used to indicate bacterial infection in sepsis. They have limited sensitivity and specificity with high cost, placing them practically out of reach for poor patients in developing countries like India. Hence the need to evaluate eosinophil count and neutrophil-lymphocyte count ratio (NLCR) as an indicator of sepsis considering their lower cost and easier accessibility. The present study was done to establish that eosinopenia and the neutrophil-lymphocyte count are simple and effective tools as prognostic biomarkers for sepsis.Methods: A prospective observational study consisting of 50 patients with SIRS and sepsis on admission were studied. Neutrophil and lymphocyte count for first 4 consecutive days and then on alternate days up to one week was done. Absolute eosinophil count for first 2 consecutive days and then on alternate days up to one week was done.Results: Eosinopenia was noted to have 79.3% sensitivity, 76.2% specificity, positive predictive value 82.2% and negative predictive value 95.4% in predicting diagnosis and prognosis of sepsis. Neutrophil-lymphocyte ratio was found to have 86.2% sensitivity, 85.7% specificity, positive predictive value of 89.2%, negative predictive value of 81.1% in predicting diagnosis and prognosis of sepsis.Conclusions: Eosinophil count and neutrophil - lymphocyte count ratio are simple and effective prognostic markers of sepsis with low cost.

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Eosinopenia, an early marker of increased mortality in critically ill medical patients

Abstract: This study suggests the possibility to use eosinophil cell count at admission and during the first 7 days as a prognosis marker of mortality in medical ICU.

Cited by 85 publications

References 37 publications

U-Shape Relationship of White Blood Cells with Acute Kidney Injury and Mortality in Critically Ill Patients

U-Shape Relationship of White Blood Cells with Acute Kidney Injury and Mortality in Critically Ill Patients

Determinants and outcomes associated with decisions to deny or to delay intensive care unit admission in Morocco

Role of eosinophil count and neutrophil: lymphocyte count ratio as prognostic markers in patients with sepsis

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