Role of eosinophil count and neutrophil: lymphocyte count ratio as prognostic markers in patients with sepsis

Hota, Prasan Kumar; Reddy, Babitha

doi:10.18203/2349-2902.isj20172774

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…The findings of the Abidi et al (36) study were (80% sensitivity and 80% specificity) for cutoff value 40cells/cu.mm.Anotherprospective observational study byHota and Reddy (38) consisting of 50 patients with SIRS and sepsis on admission were studied. They found that eosinophil count was an effective prognostic marker of sepsis with low cost.The cut off value was taken as 40cells/cu.mm.…”

Section: Fig 6: Roc Curve For Eosinophil Count For Mortality Predictmentioning

confidence: 99%

Eosinopenia as a Diagnostic Marker of Sepsis in Critically Ill Patients

Ali

Abdelsamie

2018

Egyptian Journal of Hospital Medicine

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Background: sepsis refers to the presence of a serious infection that correlates with systemic and uncontrolled immune activation. Few studies had analyzed eosinophil count as a prognostic marker of outcome in patients with infection. Eosinopenia is an interesting biomarker because the eosinophil count is always measured in clinical practice and the additional costs would therefore be negligible.The aim of this wrk: this studyaimed to test the value of eosinopenia in the diagnosis of sepsis in critically ill patients admitted to ICUs. Patients and Methods: this prospective observational, randomized study was conducted on 50 adult critically ill patients who were admitted to ICU of Ahmed Maher Teaching Hospitalin the period from March 2017to July 2017. They either had sepsis on admission or not. An informed written consent was obtained from patients and/or relatives before starting this study. Inclusion criteria were patients more than 18 years old and less than 60 years that were critically ill either in sepsis or not. Exclusion criteria were patients less than 18 years old and more than 60 years old, patient or relatives who refused to be included in this study, those with hematological cancer, HIV infection, bronchial asthma and other atopic disorders like hay fever, atopic dermatitis and allergic conjunctivitis and increased levels of eosinophil count as part of any parasitic infection or trauma patients. Results: comparison between infected and non-infected studied patients was statistically significant as regard variables of SOFA score, APACHE II score at admission, TLC and Eosinophil count at admission (p-value˂0.05). There were no statistical significant differences as regard length of ICU stay (p˃0.05). Multivariate regression analysis showed statistically significant differences and was independent predictors for infection as follow: total leucocytic count, eosinophil count at admission and SOFA score. The AUC for eosinophil count to predict was 95% with optimal cut off value was 50 cells/mm 3 with a sensitivity of 92.85% and specificity of 93.33% with P value <0.001.Conclusion: the result of the present study revealed that eosinophil counts was ˂50 cells/mm3 at admission time to ICU was a predictor for diagnosis of sepsis in critically ill patients. However, eosinophil counts at admission time to ICU were not a specific indicator of mortality. Recommendations: eosinophil counts are cheap and easily accessible test can be used to guide for sepsis diagnosis and treatment.Larger studies are needed to determine the prognostic value of this test and establish better cutoff values.

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Section: Fig 6: Roc Curve For Eosinophil Count For Mortality Predictmentioning

confidence: 99%

Eosinopenia as a Diagnostic Marker of Sepsis in Critically Ill Patients

Ali

Abdelsamie

2018

Egyptian Journal of Hospital Medicine

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Association of haemato-biochemical indices and blood composite ratios with microfilaridermia in Onchocerciasis patients

Debrah,

Gyasi,

Ahiadorme

et al. 2024

BMC Infect Dis

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Background Onchocerciasis causes chronic systemic inflammation. Several studies have used markers such as haemato-biochemical indices to predict the occurrence of systemic inflammation. This study assessed the variability and predictability of haemato-biochemical indices and blood composite ratios (BCRs) in microfilariae positive (MF+) and microfilariae negative (MF-) subgroups of onchocercomata participants. Methods One hundred and five (105) MF + and 34 MF- participants were retrospectively recruited into the study. Screening for the presence of O. volvulus microfilariae was done from skin snips taken from the left and right iliac crests of participants using established and approved protocols. Haematological and biochemical indices were measured using standard laboratory automated analyzers. Blood composite ratios (BCRs) were calculated as ratios of the absolute parameters involved. Results A significantly increased total WBC, absolute eosinophil, eosinophil percent and absolute basophil were observed in the MF + participants compared to MF- participants. Reduced gamma-glutamyl transferase (GGT) with increased estimated glomerular filtration rate (eGFR) was significantly associated with MF + participants compared to MF- participants. BCRs were significantly higher for eosinophil-to-neutrophil ratio (ENR), eosinophil-to-monocyte ratio (EMR), eosinophil-to-basophil ratio (EBR) and eosinophil-to-lymphocyte ratio (ELR) in MF + participants compared to MF- participants. After multivariate adjustment, onchocercomata participants with increased eosinophil counts (aOR = 13.86, 95% CI [2.07–92.90], p = 0.007), ENR x10 (aOR = 1.42, 95% CI [1.05–1.93], p = 0.025), EMR (aOR = 2.64, 95% CI [1.25–5.60], p = 0.011), EBR (aOR = 1.07, 95% CI [1.01–1.10], p = 0.020) and ELR x10 (aOR = 1.69, 95% CI [1.14–2.51], p = 0.009) were more likely to have microfilaridermia. Conclusions Elevated eosinophil counts with higher ENR, EMR, EBR and ELR levels are significantly associated with microfilaridermia in onchocercomata participants. Combining BCRs with eosinophil count significantly led to an improvement in the conventional model for predicting microfilaridermia.

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Role of eosinophil count and neutrophil: lymphocyte count ratio as prognostic markers in patients with sepsis

Cited by 2 publications

References 6 publications

Eosinopenia as a Diagnostic Marker of Sepsis in Critically Ill Patients

Eosinopenia as a Diagnostic Marker of Sepsis in Critically Ill Patients

Association of haemato-biochemical indices and blood composite ratios with microfilaridermia in Onchocerciasis patients

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