2013
DOI: 10.1016/j.mito.2013.08.011
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Enzymes involved in l-lactate metabolism in humans

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Cited by 72 publications
(63 citation statements)
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“…Furthermore, we suggested that there is a link between reduction in ALT enzyme activity and the reduction in glucose levels due to the fact the ALT be important for gluconeogenesis, since the alanine becomes available for this pathway (Adeva et al, 2013). The levels of cholesterol and AST activity were unchanged in mice treated with Eta, which indicate the lack of major toxic effects in organs such as liver and kidneys (da .…”
Section: Discussionmentioning
confidence: 98%
“…Furthermore, we suggested that there is a link between reduction in ALT enzyme activity and the reduction in glucose levels due to the fact the ALT be important for gluconeogenesis, since the alanine becomes available for this pathway (Adeva et al, 2013). The levels of cholesterol and AST activity were unchanged in mice treated with Eta, which indicate the lack of major toxic effects in organs such as liver and kidneys (da .…”
Section: Discussionmentioning
confidence: 98%
“…Cytoplasmic and mitochondrial PEPCK-C and PEPCK-M are involved in gluconeogenesis, using lactate as a substrate. 22,26 Both PEPCK-C and PEPCK-M mRNA levels were not significantly altered in hepatoma cell lines treated with AgNPs for 3 hours compared to those in negative controls (Figure 3). Nrf2 participates in glucose metabolism by regulating the expression of enzymes involved in the PPP, such as G6PDH, 6PGD, TKT, and TALDO.…”
Section: Decreased Mrna Levels Of Nrf2 In Cells Treated With 5 Nm Agnpsmentioning
confidence: 97%
“…Exhibits chaperonic property with various proteins involving in ER homeostasis and cell proliferation and migration (Park et al, 2011) Tropomysin Similar to Myosin-11 14-3-3 protein Modulates signaling pathway by interacting with kinases, phosphatases, and transmembrane receptors (Butt et al, 2012) Elongation factor 1 Transports the aminoacyl-tRNAs to the ribosome during the elongation process (Riis et al, 1990) Chymotrypsin-like elastase Involved in host defense function by degrading virulence factors of pathogenic bacteria (Averhoff et al, 2008) L-Lactate dehydrogenase A Catalyzes the conversion of pyruvate to lactate (Adeva et al, 2013) Peroxisomal multifunctional enzyme Involved in peroxisomal beta-oxidation of fatty acid (Poirier et al, 2006) Heat shock protein 90…”
Section: Statementioning
confidence: 99%