Enzymes as Therapeutic Agents in Human Disease Management

Babbal,; Adivitiya,; Mohanty, S. R.; Khasa, Yogender Pal

doi:10.1002/9781119460053.ch10

Cited by 1 publication

(1 citation statement)

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“…[ 3 ] β‐ galactosidase is another important bacterial enzyme that sequentially releases β linked terminal galactosyl residues that favours tumour growth and metastatic infiltration in the intestine. [ 70 ] Along with this, mucinase critically degrades the mucosal layer of the intestine and favours the genotoxins to induce inflammation in the colon epithelial cells. [ 71 ] The genotoxins are partly activated by cytochrome p450 to hydroxy amino derivatives which form esters of N‐acetyl transferase and sulfotransferase.…”

Section: Myrtenalmentioning

confidence: 99%

Potential molecular mechanisms of myrtenal against colon cancer: A systematic review

Boopathy,

Roy,

Gopal

et al. 2023

J Biochem & Molecular Tox

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Colon cancer is a serious health problem across the globe with various dietary lifestyle modifications. It arises as an inflammation mediated crypts in the colon epithelial cells and undergoes uncontrolled cell division and proliferation. Bacterial enzymes contribute to a major outbreak in colon cancer development upon the release of toxic metabolites from the gut microflora. Pathogen associated molecular patterns and damage associated molecular patterns triggers the NLPR3 inflammasome pathways that releases pro‐inflammatory cytokines to induce cancer of the colon. Contributing to this, specific chemokines and receptor complexes attribute to cellular proliferation and metastasis. Bacterial enzymes synergistically attack the colon mucosa and degenerate the cellular integrity causing lysosomal discharge. These factors further instigate the Tol like receptors (TLRs) and Nod like receptors (NLRs) to promote angiogenesis and supply nutrients for the cancer cells. Myrtenal, a monoterpene, is gaining more importance in recent times and it is being widely utilized against many diseases such as cancers, neurodegenerative diseases and diabetes. Based on the research data's, the reviews focus on the anticancer property of myrtenal by emphasizing its therapeutic properties which downregulate the inflammasome pathways and other signalling pathways. Combination therapy is gaining more importance as they can target every variant in the cellular stress condition. Clinical studies with compounds like myrtenal of the monoterpenes family is provided with positive results which might open an effective anticancer drug therapy. This review highlights myrtenal and its biological potency as a cost effective drug for prevention and treatment of colon cancer.

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Section: Myrtenalmentioning

confidence: 99%