Enzymes | Angiogenin – A Homolog of Ribonuclease A

Subramanian, Vasanta; Ferguson, Ross; Acharya, K. Ravi

doi:10.1016/b978-0-12-819460-7.00022-0

Cited by 1 publication

(1 citation statement)

References 159 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ANG is an effective inducer of angiogenesis in vivo and is associated with multiple human neoplasms, diabetic retinopathy, and arthritis. ANG performs a fundamental function in ribosome biogenesis and many cellular processes [ 60 ]. However, proteomic profiling of urine has been recommended as an indicative test for BCa [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Aalami

Abdeahad

Mesgari

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Aims. Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis, we examine the diagnostic role of the angiogenin (ANG) protein in patients’ urine with bladder neoplasm. Methods. We performed a systematic literature search using ScienceDirect, Web of Science, PubMed/MEDLINE, Scopus, Google Scholar, and Embase, up to 10th October 2020 databases. Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.2.2 software calculated the pooled specificity, sensitivity, area under the curve (AUC), diagnostic odds ratio (DOR), positive likelihood ratio (LR+), negative likelihood ratio (LR-), Q ∗ index, and summary receiver-operating characteristic (SROC) for the role of ANG as a urinary biomarker for BCa patients. Results. Four case-control studies were included with 656 participants (417 cases and 239 controls) in this meta-analysis. The pooled sensitivity of 0.71 (95% CI: 0.66–0.75), specificity of 0.78 (95% CI: 0.73–0.81), LR+ of 3.34 (95% CI: 2.02–5.53), LR- of 0.37 (95% CI: 0.32–0.44), DOR of 9.99 (95% CI: 4.69–21.28), and AUC of 0.789 and Q ∗ index of 0.726 demonstrate acceptable diagnostic precision of ANG in identifying BCa. Conclusion. This meta-analysis showed that ANG could be a fair biomarker for the diagnosis of BCa patients.

show abstract

Section: Discussionmentioning

confidence: 99%